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Structural and Functional Regulation of Desmosomes

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Rise and Fall of Epithelial Phenotype

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Intercellular adhesion and communication in mammalian epithelial cells occurs via special ized junctional complexes, which include tight junctions, adherens junctions, desmosomes, and gap junctions (Fig. 1).[1] Desmosomes are unique among these junctions, as they are coupled to the intermediate filament (IF)-based cytoskeleton. These form stable complexes that facilitated the ultrastructural and biochemical characterization of desmosomes but also made progress in the molecular organization of these junctions more challenging.[2]–[5] Although the individual components that make up a desmosome are now fairly well established, we are just beginning to appreciate how desmosomes are assembled into highly regulated and dynamic adhesive units.

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Authors and Affiliations

  1. Departments of Pathology and Dermatology and the Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

    Spiro Getsios & Lisa M. Godsel

  2. Department of Pathology, Northwestern University Medical School, Chicago, Illinois, USA

    Kathleen J. Green

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  1. Spiro Getsios
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Getsios, S., Godsel, L.M., Green, K.J. (2005). Structural and Functional Regulation of Desmosomes. In: Rise and Fall of Epithelial Phenotype. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-28671-3_10

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