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Activation of NOS Interneurones in Striatum after Excitotoxic Lesions of Rat Globus Pallidus

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The Basal Ganglia VIII

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 56))

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5. Conclusions

On the same side of the brain as the ibotenic acid lesion of the globus pallidus we have evidence of a reduction in the activity of diaphorase in the striatum. Such a reduction is compatible with a reduction in the stores of NOS in the cells perhaps as a result of the overproduction of the transmitter NO. We assume that the production of this potentially toxic substance is normally limited by inhibition from the GP. The number of parvalbumin positive neurones does not seem to have been changed by the lesion.

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Fernandez, M.L., Wright, A.K., Arbuthnott, G.W. (2005). Activation of NOS Interneurones in Striatum after Excitotoxic Lesions of Rat Globus Pallidus. In: Bolam, J.P., Ingham, C.A., Magill, P.J. (eds) The Basal Ganglia VIII. Advances in Behavioral Biology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/0-387-28066-9_46

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