Abstract
Greater understanding of the rate of oxygen delivery and uptake in sick preterm and term infants undergoing intensive care is an important aim of brain-orientated neonatal medicine. Near infrared spectroscopy (NIRS) is a continuous, non-invasive and portable technique which can be used to measure cerebral blood flow (CBF) in infants. It is also possible to use spatially resolved spectroscopy to measure absolute mean cerebral oxygen saturation (SmcO2). The aim of this study was to investigate the derivation of cerebral metabolic rate for oxygen (CMRO2) from these two measurements. Nine preterm infants were studied, of median (range) gestational age 25 (23–37) weeks. A NIRO300 was used to measure CBF and SmcO2 simultaneously over the right and left hemisphere. Median (range) left and right cerebral hemisphere values for CMRO2 were 0.95 (0.79–1.53) ml 100g−1.min−1 and 0.88 (0.69–1.46) ml 100g−1.min−1, respectively. No significant difference was seen between the left- and right-sided values. These values are similar to median (range) values previously reported in infants using positron emission tomography or more invasive NIRS methods. Further work is necessary to define limits on the use of this technique, particularly in the assumption of the venous:arterial compartment volume ratio across different infants.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
W. J. Powers, R. L. Grubb, D. Darriet, and M. E. Raichle, Cerebral blood flow and cerebral metabolic rate of oxygen for cerebral function in humans, J. Cereb. Blood Flow Melab. 5, 600–608 (1985).
D. I. Altman, J. M. Perlman, J. J. Volpe, and W. J. Powers, Cerebral oxygen metabolism in newborns, Pediatrics 92, 99–104 (1993).
L. Skov, O. Pryds, G. Griesen, and H. Lou, Estimation of cerebral venous saturation in newborn infants by near infrared spectroscopy, Pediatr. Res. 33, 52–55 (1993).
C. W. Yoxall, and M. Weindling, Measurement of cerebral oxygen consumption in the human neonate using near infrared spectroscopy: cerebral oxygen consumption increases with advancing gestational age, Pediatr. Res. 44(3), 283–290 (1998).
I. C. Gregory, The oxygen and carbon monoxide capacities of foetal and adult blood, J. Physiol. 236, 625 (1974).
A. D. Edwards, J. S. Wyatt, C. E. Richardson, D. T. Delpy, M. Cope, and E. O. Reynolds, Cotside measurement of cerebral blood flow in ill newborn infants by near infrared spectroscopy, Lancet 2(8614), 770–771 (1988).
S. J. Matcher, P. Kirkpatrick, K. Nahid, M. Cope, and D. T. Delpy, Absolute quantification methods in tissue near-infrared spectroscopy, Proc. SPIE 2389, 486–495 (1995).
C. E. Elwell, M. Cope, A. D. Edwards, J. S. Wyatt, D. T. Delpy, and E. O. R Reynolds, Quantification of adult cerebral haemodynamics by near infrared spectroscopy, J. Applied Physiol. 77, 2753–2760 (1994).
A. Duncan, J. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope, and D. T. Delpy, Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy, Phys. Med. Biol. 40, 295–304 (1995).
G. McHedlishvili, Arterial behaviour and blood circulation in brain (Plenum Press, New York, 1986).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer Science+Business Media, Inc.
About this paper
Cite this paper
Elwell, C.E. et al. (2005). Measurement of CMRO2 in Neonates Undergoing Intensive Care Using Near Infrared Spectroscopy. In: Okunieff, P., Williams, J., Chen, Y. (eds) Oxygen Transport to Tissue XXVI. Advances in Experimental Medicine and Biology, vol 566. Springer, Boston, MA. https://doi.org/10.1007/0-387-26206-7_35
Download citation
DOI: https://doi.org/10.1007/0-387-26206-7_35
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-25062-5
Online ISBN: 978-0-387-26206-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)