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The changing faces of Crohn’s disease and ulcerative colitis

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Inflammatory Bowel Disease: From Bench to Bedside

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References

  1. Craig G. Alfred the Great: a diagnosis. J R Soc Med 1991; 84: 303–5.

    PubMed  CAS  Google Scholar 

  2. Wilson PJE. The young pretender. (Correspondence) Br Med J 1961; 1: 1226.

    Google Scholar 

  3. Hawkins HP. Natural history of ulcerative colitis and its bearing on treatment. Br Med J 1909; 1: 765–70.

    PubMed  Google Scholar 

  4. Dalziel TK. Chronic interstitial enteritis. Br J Med 1913; 2: 1068–70.

    Google Scholar 

  5. Walker JF, Fielding JF. Crohn’s disease in Dublin in the latter half of the nineteenth century. Ir J Med Sci 1988; 157: 235–7.

    PubMed  CAS  Google Scholar 

  6. Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis. A pathological and clinical entity. J Am Med Assoc 1932; 99: 1323–9.

    Google Scholar 

  7. Stonnington CM, Phillips SF, Melton III LJ, Zinsmeister AR. Chronic ulcerative colitis: incidence and prevalence in community. Gut 1987; 28: 402–9.

    PubMed  CAS  Google Scholar 

  8. Sedlack RE, Nobrega FT, Kurland LT, Sauer WG. Inflammatory colon disease in Rochester, Minnesota, 1935–1964. Gastroenterology 1972; 62: 935–41.

    PubMed  CAS  Google Scholar 

  9. Rose JDR, Roberts GM, Williams, Mayberry JF, Rhodes J. Cardiff Crohn’s disease jubilee: the incidence over 50 years. Gut 1988; 29: 346–51.

    PubMed  CAS  Google Scholar 

  10. Sonnenberg A. Geographic variation in the incidence of and mortality from inflammatory bowel disease. Dis Colon Rectum 1986; 29: 854–61.

    PubMed  CAS  Google Scholar 

  11. Orholm M, Munkholm P, Langholz E, Haagen Nielsen O, Sörensen TIA, Binder V. Familial occurrence of inflammatory bowel disease. N Engl J Med 1991; 324: 84–8.

    Article  PubMed  CAS  Google Scholar 

  12. Samuelsson SM. Ulcerös colit och proctit. Uppsala: Department of Social Medicine. University of Uppsala: thesis, 1976.

    Google Scholar 

  13. Norlén BJ, Krause U, Bergman L. An epidemiologic study of Crohn’s disease. Scand J Gastroenterol 1970; 5: 385–90.

    PubMed  Google Scholar 

  14. Bergman L, Krause U. The incidence of Crohn’s disease in central Sweden. Scand J Gastroenterol 1975; 10: 725–9.

    PubMed  CAS  Google Scholar 

  15. Ekbom A, Helmick C, Zack M, Adami HO. The epidemiology of inflammatory bowel disease: a large, population based study in Sweden. Gastroenterology 1991; 100: 350–8.

    PubMed  CAS  Google Scholar 

  16. Björnsson S. Inflammatory bowel disease in Iceland during a 30-year period, 1950–1979. Scand J Gastroenterol 1989; 24(Suppl. 170): 47–9.

    Google Scholar 

  17. Bjornsson S, Johannsson JH, Oddsson E. Inflammatory bowel disease in Iceland, 1980–89. A retrospective nation-wide epidemiologic study. Scand J Gastroenterol 1998; 33: 71–7.

    PubMed  CAS  Google Scholar 

  18. Bjornsson S, Johannsson JH. Inflammatory bowel disease in Iceland, 1990–1994: a prospective, nationwide, epidemiological study. Eur J Gastroenterol Hepatol 2000; 12: 31–8.

    Article  PubMed  CAS  Google Scholar 

  19. Binder V, Both H, Hansen PK, Hendriksen C, Kreiner S, Torp-Pedersen K. Incidence and prevalence of lcerative colitis and Crohn’s disease in the County of Copenhagen 1962–1978. Gastroenterology 1982; 83: 563–8.

    PubMed  CAS  Google Scholar 

  20. Munkholm P, Langholtz E, Haagen Nielsen O, Kreiner S, Binder V. Incidence and prevalence of Crohn’s disease in the County of Copenhagen, 1962–87: a sixfold increase in incidence. Scand J Gastroenterol 1992; 27: 609–14.

    PubMed  CAS  Google Scholar 

  21. Langholz E, Munkholm P, Nielsen OH, Kreiner S, Binder V. Incidence and prevalence of ulcerative colitis in openhagen county from 1962 to 1987. Scand J Gastroenterol 1991; 26: 1247–56.

    PubMed  CAS  Google Scholar 

  22. Berner J, Kiaer T. Ulcerative colitis and Crohn’s disease on the Faroe Islands 1964–1983. Scand J Gastroenterol 1986; 21: 188–92.

    PubMed  CAS  Google Scholar 

  23. Roin F, Roin J. Inflammatory bowel disease of the Faroe Islands, 1981–1988. Scand J Gastroenterol 1989; 24(Suppl. 170): 44–6.

    Google Scholar 

  24. Sedlack RE, Whisnant J, Elveback LR, Kurland LT. Incidence of Crohn’s disease in Olmstead County, Minnesota, 1935–1975. Am J Epidemiol 1980; 112: 759–63.

    PubMed  CAS  Google Scholar 

  25. Gollop JH, Phillips SF, Melton LJD, Zinsmeister AR. Epidemiologic aspects of Crohn’s disease: a population based study in Olmsted County, Minnesota, 1943–1982. Gut 1988; 29: 49–56.

    PubMed  CAS  Google Scholar 

  26. Loftus EV, Jr, Silverstein MD, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR. Crohn’s disease in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival. Gastroenterology 1998; 114: 1161–8.

    PubMed  Google Scholar 

  27. Loftus EV, Jr, Silverstein MD, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR. Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival. Gut 2000; 46: 336–43.

    PubMed  Google Scholar 

  28. Thomas GA, Millar-Jones D, Rhodes J, Roberts GM, Williams GT, Mayberry JF. Incidence of Crohn’s disease in Cardiff over 60 years: 1986–1990; an update. Eur J Gastroenterol Hepatol 1995; 7: 401–5.

    PubMed  CAS  Google Scholar 

  29. Mourn B, Vatn MH, Ekbom A et al. Incidence of ulcerative colitis and indeterminate colitis in four counties in south-eastern Norway, 1990 1993. Scand J Gastroenterol 1996; 31: 362–6.

    Google Scholar 

  30. Gower-Rousseau C, Salomez JL, Dupas JL et al. Incidence of inflammatory bowel disease in northern France (1988 1990). Gut 1994; 35: 1433–8.

    PubMed  CAS  Google Scholar 

  31. Latour P, Louis E, Belaiche J. Incidence of inflammatory bowel disease in the area of Liege: a 3 years prospective study (1993 1996). Acta Gastroenterol Belg 1998; 61: 410–13.

    PubMed  CAS  Google Scholar 

  32. Nordcnvall B, Brostrom O, Berglund M, et al. Incidence of ulcerative colitis in Stockholm County 1955–1979. Scand J Gastroenterol 1985; 20: 783–90.

    Google Scholar 

  33. Hughes CW, Baugh JH, Mologne LA, Heaton LD. A review of the late General Eisenhower’s operations: epilog to a footnote to history. Ann Surg 1971; 173: 793–9.

    PubMed  CAS  Google Scholar 

  34. Armitage E, Drummond H, Ghosh S, Ferguson A. Incidence of juvenile-onset Crohn’s disease in Scotland. Lancet 1999; 353: 1496–7.

    PubMed  CAS  Google Scholar 

  35. Askling J, Grahnquist L, Ekbom A, Finkel Y. Incidence of paediatric Crohn’s disease in Stockholm, Sweden. Lancet 1999; 354: 1179.

    PubMed  CAS  Google Scholar 

  36. Lindberg E, Lindquist B, Holmquist L, Hildebrand H. Inflammatory bowel disease in children and adolescents in Sweden, 1984–1995. J Pediatr Gastroenterol Nutr 2000; 30: 259–64.

    PubMed  CAS  Google Scholar 

  37. Tysk C, Jarnerot G. Has smoking changed the epidemiology of ulcerative colitis? Scand J Gastroenterol 1992; 27: 508–12.

    PubMed  CAS  Google Scholar 

  38. Evans JG, Acheson ED. An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area. Gut 1965; 6: 311–24.

    PubMed  CAS  Google Scholar 

  39. Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative proctitis in central Sweden 1965–1983. A population-based epidemiological study. Dig Dis Sci 1991; 36: 97–102.

    PubMed  CAS  Google Scholar 

  40. Farmer RG, Brown CH. Course and prognosis of ulcerative proctosigmoiditis. Am J Gastroenterol 1971; 56: 227–34.

    PubMed  CAS  Google Scholar 

  41. Powell-Tuck J, Ritchie JK, Lennard-Jones JE. The prognosis of idiopathic proctitis. Scand J Gastroenterol 1977; 12: 727–32.

    PubMed  CAS  Google Scholar 

  42. Ghosh S, Shand A, Ferguson A. Ulcerative colitis. Br Med J 2000; 320: 1119–23.

    CAS  Google Scholar 

  43. Korelitz BI. From Crohn to Crohn’s disease: 1979; an epidemiologic study in New York City. Mt Sinai J Med 1979; 46: 533–40.

    Google Scholar 

  44. Lockhart-Mummery HE, Morson BC. Crohn’s disease (regional enteritis) of the large intestine and its distribution from ulcerative colitis. Gut 1960; 1: 87–105.

    PubMed  CAS  Google Scholar 

  45. Price AB. Overlap in the spectrum of non-spectrum inflammatory bowel disease — ‘colitis-indeterminate’. J Clin Pathol 1978; 31: 567–77.

    PubMed  CAS  Google Scholar 

  46. Leijonmarck CE, Lofberg R, Ost A, Hellers G. Long-term results of ileorectal anastomosis in ulcerative colitis in Stockholm County. Dis Colon Rectum 1990; 33: 195–200.

    PubMed  CAS  Google Scholar 

  47. Shivananda S, Lennard-Jones J, Logan R et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut. 1996; 39(5): 690–7.

    PubMed  CAS  Google Scholar 

  48. Mourn B, Ekbom A, Vatn MH et al. Inflammatory bowel disease: re-evaluation of the diagnosis in a prospective population based study in south eastern Norway. Gut 1997; 40: 328–32.

    Google Scholar 

  49. Stewenius J, Adnerhill I, Ekelund G et al. Ulcerative colitis and indeterminate colitis in the city of Malmo, Sweden. A 25-year incidence study. Scand J Gastroenterol 1995; 30: 38–43.

    PubMed  CAS  Google Scholar 

  50. Kyle J. Crohn’s disease in the northeastern and northern Isles of Scotland: an epidemiological review. Gastroenterology 1992; 103: 392–9.

    PubMed  CAS  Google Scholar 

  51. Sonnenberg A, McCarty DJ, Jacobsen SJ. Geographic variation in inflammatory bowel disease within the United States. Gastroenterology 1991; 100: 143–9.

    PubMed  CAS  Google Scholar 

  52. Brahme F, Lindstrom C, Wenckert A. Crohn’s disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmo, Sweden. Gastroenterology 1975; 69: 342–51.

    PubMed  CAS  Google Scholar 

  53. Nyhlin H, Danielsson A. Incidence of Crohn’s disease in a defined population in Northern Sweden. Scand J Gastroenterol 1986; 21: 1185–92.

    PubMed  CAS  Google Scholar 

  54. Hellers G. Crohn’s disease in Stockholm County, 1955–1974. Acta Chir Scand 1979; 490(Suppl. 1): 1–84.

    CAS  Google Scholar 

  55. Lindberg E, Järnerot G. The incidence of Crohn’s disease is not decreasing in Sweden. Scand J Gastroenterol 1991; 26: 495–500.

    PubMed  CAS  Google Scholar 

  56. Tysk C, Jarnerot G. Ulcerative proctocolitis in Orebro, Sweden. A retrospective epidemiologic study, 1963–1987. Scand J Gastroenterol 1992; 27: 945–50.

    PubMed  CAS  Google Scholar 

  57. Trallori G, d’Albasio G, Palli D et al. Epidemiology of inflammatory bowel disease over a 10-year period in Florence (1978–1987). Ital J Gastroenterol 1991; 23: 559–63.

    PubMed  CAS  Google Scholar 

  58. Cottone M, Cipolla C, Orlando A, Olivia L, Salerno G, Pagliaro L. Hospital incidence of Crohn’s disease in the province of Palermo. Scand J Gastroenterol 1989; 24(Suppl. 170): 27–8.

    Google Scholar 

  59. Tsianos EV, Masalas CN, Merkouropoulos M, Dalekos GN, Logan RF. Incidence of inflammatory bowel disease in northwest Greece: rarity of Crohn’s disease in an area where ulcerative colitis is common. Gut 1994; 35: 369–72.

    PubMed  CAS  Google Scholar 

  60. Manousos ON, Koutroubakis I, Potamianos S, Roussomoustakaki M, Gourtsoyiannis N, Vlachonikolis IG. A prospective epidemiologic study of Crohn’s disease in Heraklion, Crete. Incidence over a 5-year period. Scand J Gastroenterol 1996; 31: 599–603.

    PubMed  CAS  Google Scholar 

  61. Manousos ON, Giannadaki E, Mouzas IA et al. Ulcerative colitis is as common in Crete as in northern Europe: a 5-year prospective study. Eur J Gastroenterol Hepatol 1996; 8: 893–8.

    PubMed  CAS  Google Scholar 

  62. Kull K, Salupere R, Uibo R, Ots M, Salupere V. Antineutrophil cytoplasmic antibodies in Estonian patients with inflammatory bowel disease. Prevalence and diagnostic role Hepatogastroenterology 1998; 45: 2132–7.

    CAS  Google Scholar 

  63. Ihasz M, Batorfl J, Balint A et al. Surgical relations of Crohn’s disease and the frequency of recurrence. Acta Chir Hung 1995; 35: 63–75.

    PubMed  Google Scholar 

  64. Vucelic B, Korac B, Sentic M, et al. Ulcerative colitis in Zagreb, Yugoslavia: incidence and prevalence 1980–1989. Int J Epidemiol 1991; 20: 1043–7.

    PubMed  CAS  Google Scholar 

  65. Delco F, Sonnenberg A. Exposure to risk factors for ulcerative colitis occurs during an early period of life. Am J Gastroenterol 1999; 94: 679–84.

    PubMed  CAS  Google Scholar 

  66. Acheson ED. The distribution of ulcerative colitis and regional enteritis in United States veterans with particular reference to the Jewish religion. Gut 1960; 1: 291–3.

    PubMed  CAS  Google Scholar 

  67. Wright JP, Froggatt J, O’Keefe EA et al. The epidemiology of inflammatory bowel disease in Cape Town 1980–1984. S Afr Med J 1986; 70: 10–15.

    PubMed  CAS  Google Scholar 

  68. Mayberry JF, Judd D, Smart H, Rhodes J, Calcraft B, Morris JS. Crohn’s disease in Jewish people — an epidemiological study in south-east Wales. Digestion 1986; 35: 237–40.

    PubMed  CAS  Google Scholar 

  69. Monk M, Mendeloff AI, Siegel CI, Lilienfeld A. An epidemiological study of ulcerative colitis and regional enteritis among adults in Baltimore. I. Hospital incidence and prevalence, 1960 to 1963. Gastroenterology 1968; 54:(Suppl.): 822–4.

    PubMed  Google Scholar 

  70. Odes HS, Locker C, Neumann L et al. Epidemiology of Crohn’s disease in southern Israel. Am J Gastroenterol 1994; 89: 1859–62.

    PubMed  CAS  Google Scholar 

  71. Roth MP, Petersen GM, McElree C, Feldman E, Rotter JI. Geographic origins of Jewish patients with inflammatory bowel disease. Gastroenterology 1989; 97: 900–4.

    PubMed  CAS  Google Scholar 

  72. Jayanthi V, Probert CSJ, Pinder D, Wicks ACB, Mayberry JF. Epidemiology of Crohn’s disease in Indian migrants and the indigenous population in Leicestershire. Q J Med 1992; 298: 125–38.

    Google Scholar 

  73. Odes HS, Fraser D, Krugliak P, Fenyves D, Fraser GM, Sperber AD. Inflammatory bowel disease in the Bedouin Arabs of southern Israel: rarity of diagnosis and clinical features. Gut 1991; 32: 1024–6.

    PubMed  CAS  Google Scholar 

  74. Calkins BM, Lilienfeld AM, Garland CF, Mendeloff AI. Trends in incidence rates of ulcerative colitis and Crohn’s disease. Dig Dis Sci 1984; 29: 913–20.

    PubMed  CAS  Google Scholar 

  75. Kurata JH, Kantor-Fish S, Frankl H, Godby P, Vadheim CM. Crohn’s disease among ethnic groups in a large health maintenance organization. Gastroenterology 1992; 102: 1940–8.

    PubMed  CAS  Google Scholar 

  76. Thompson NP, Montgomery SM, Wadsworth ME, Pounder RE, Wakefield AJ. Early determinants of inflammatory bowel disease: use of two national longitudinal birth cohorts. Eur J Gastroenterol Hepatol 2000; 12: 25–30.

    PubMed  CAS  Google Scholar 

  77. Carr I, Mayberry JF. The effects of migration on ulcerative colitis: a three-year prospective study among Europeans and first-and second-generation South Asians in Leicester (1991–1994). Am J Gastroenterol 1999; 94: 2918–22.

    PubMed  CAS  Google Scholar 

  78. Acheson ED, Nefzger MD. Ulcerative colitis in the United States Army in 1944. Epidemiology: comparisons between patients and controls. Gastroenterology 1963; 44: 7–19.

    PubMed  CAS  Google Scholar 

  79. Sonnenberg A. Disability from inflammatory bowel disease among employees in West Germany. Gut 1989; 30: 367–70.

    PubMed  CAS  Google Scholar 

  80. Gilat T, Hacohen D, Lilos P, Langman MJS. Childhood factors in ulcerative colitis and Crohn’s disease. Scand J Gastroenterol 1987; 22: 1009–24.

    PubMed  CAS  Google Scholar 

  81. Ekbom A, Adami HO, Helmick CG, Jonzon A, Zack MM. Perinatal risk factors for inflammatory bowel disease: a case-control study. Am J Epidemiol 1990; 132: 1111–19.

    PubMed  CAS  Google Scholar 

  82. Andresen AFR. Gastrointestinal manifestations of food allergy. Med J Rec 1925; 122(Suppl.): 271–5.

    Google Scholar 

  83. Truelove SC. Ulcerative colitis provoked by milk. Br Med J 1961; 1: 154–60.

    PubMed  CAS  Google Scholar 

  84. Pena AS, Truelove SC. Hypolactasia and ulcerative colitis. Gastroenterology 1973; 64: 400–4.

    PubMed  CAS  Google Scholar 

  85. Persson PG, Ahlbom A, Hellers G. Diet and inflammatory bowel disease: a case-control study. Epidemiology 1992; 3: 47–52.

    PubMed  CAS  Google Scholar 

  86. Persson PG, Ahlbom A, Hellers G. Crohn’s disease and ulcerative colitis. A review of dietary studies with emphasis on methodologic aspects. Scand J Gastroenterol 1987; 22: 385–9.

    PubMed  CAS  Google Scholar 

  87. Guthy E. Morbus Crohn and Nahrungsfette — Hypothese zur Ätiologie der Enteritis regionalis. Dt Med Wochenschr 1982; 107: 71–3.

    CAS  Google Scholar 

  88. Sonnenberg A. Geographic and temporal variations of sugar and margarine consumption in relation to Crohn’s disease. Digestion 1988; 41: 161–71.

    PubMed  CAS  Google Scholar 

  89. James AH. Breakfast and Crohn’s disease. Br Med J 1977; 1: 943–5.

    PubMed  CAS  Google Scholar 

  90. Russel MG, Engels LG, Muris JW et al. ‘Modern life’ in the epidemiology of inflammatory bowel disease: a case-control study with special emphasis on nutritional factors. Eur J Gastroenterol Hepatol 1998; 10: 243–9.

    PubMed  CAS  Google Scholar 

  91. Boller R. Erfahrungen an 89 Colitis-ulcerosa-Fällen der Abteilung Boller im allgemeinen Krankenhaus Wien. Gastroenterologia 1956; 86: 693–6.

    PubMed  CAS  Google Scholar 

  92. Samuelsson SM, Ekbom A, Zack M, Helmick CG, Adami HO. Risk factors for extensive ulcerative colitis and ulcerative proctitis: a population based case-control study. Gut 1991; 32: 1526–30.

    PubMed  CAS  Google Scholar 

  93. Harries AD, Baird A, Rhodes J. Non-smoking: a feature of ulcerative colitis. Br Med J (Clin Res Ed) 1982; 284: 706.

    CAS  Google Scholar 

  94. Calkins BM. A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci 1989; 34: 1841–54.

    PubMed  CAS  Google Scholar 

  95. Pullan RD, Rhodes J, Ganesh S et al. Transdermal nicotine for active ulcerative colitis. N Engl J Med 1994; 330: 811–5.

    PubMed  CAS  Google Scholar 

  96. Franceschi S, Panza E, La Vecchia C, Parazzini F, Decarli A, Bianchi Porro G. Nonspecific inflammatory bowel disease and smoking. Am J Epidemiol 1987; 125: 445–52.

    PubMed  CAS  Google Scholar 

  97. Benoni C, Nilsson Å. Smoking habits in patients with inflammatory bowel disease. Scand J Gastroenterol 1987; 22: 1130–6.

    PubMed  CAS  Google Scholar 

  98. Cottone M, Rosselli M, Orlando A et al. Smoking habits and recurrence in Crohn’s disease. Gastroenterology 1994; 106: 643–8.

    PubMed  CAS  Google Scholar 

  99. Wakefield AD, Sawyerr AM, Hudson M, Dhillon AP, Pounder RE. Smoking, the oral contraceptive pill, and Crohn’s disease. Dig Dis Sci 1991; 36: 1147–50.

    PubMed  CAS  Google Scholar 

  100. Rachmilewitz D. On smoking, rats, and inflammatory bowel disease. Gastroenterology. 1999; 117: 1008–11.

    PubMed  CAS  Google Scholar 

  101. Reif S, Klein I, Arber N, Gilat T. Lack of association between smoking and inflammatory bowel disease in Jewish patients in Israel. Gastroenterology 1995; 108: 1683–7.

    PubMed  CAS  Google Scholar 

  102. Reif S, Lavy A, Keter D et al. Lack of association between smoking and Crohn’s disease but the usual association with ulcerative colitis in Jewish patients in Israel: a multicenter study. Am J Gastroenterol 2000; 95: 474–8.

    PubMed  CAS  Google Scholar 

  103. Lesko SM, Kaufman DW, Rosenberg L et al. Evidence for an increased risk of Crohn’s disease in oral contraceptive users. Gastroenterology 1985; 89: 1046–9.

    PubMed  CAS  Google Scholar 

  104. Rhodes JM, Cockel R, Allan RN, Hawker PC, Dawson J, Elias E. Colonic Crohn’s disease and use of oral contraception. Br Med J 1984; 1: 595–96.

    Google Scholar 

  105. Lashner BA, Kane SV, Hanauer SB. Lack of association between oral contraceptive use and Crohn’s disease colitis. Gastroenterology 1989; 97: 1442–7.

    PubMed  CAS  Google Scholar 

  106. Sutherland LR, Ramcharan S, Bryant H, Fick G. Effect of oral contraceptive use on reoperation following surgery for Crohn’s disease. Dig Dis Sci 1992; 37: 1377–82.

    PubMed  CAS  Google Scholar 

  107. Sandler RS, Wurzelmann JI, Lyles CM. Oral contraceptive use and the risk of inflammatory bowel disease. Epidemiology 1992; 3: 374 8.

    PubMed  CAS  Google Scholar 

  108. Katschinski B, Fingerle D, Scherbaum B, Goebell H. Oral contraceptive use and cigarette smoking in Crohn’s disease. Dig Dis Sci 1993; 38: 1596–600.

    PubMed  CAS  Google Scholar 

  109. Boyko EJ, Theis MK, Vaughan TL, Nicol-Blades B. Increased risk of inflammatory bowel disease associated with oral contraceptive use. Am J Epidemiol 1994; 140: 268–78.

    PubMed  CAS  Google Scholar 

  110. Allan R, Pease P, Ibbotson JP. Clustering of Crohn’s disease in a Cotswold village. Q J Med 1986; 229: 473–8.

    Google Scholar 

  111. Reilly RP, Robinson TJ. Crohn’s disease — is there a long latent period? Postgrad Med J 1986; 62: 353–4.

    PubMed  CAS  Google Scholar 

  112. Aisenberg J, Janowitz HD. Cluster of inflammatory bowel disease in three close college friends? J Clin Gastroenterol 1993; 17: 18–20.

    PubMed  CAS  Google Scholar 

  113. Rhodes JM, Marshall T, Hamer JD, Allan RN. Crohn’s disease in two married couples. Gut 1985; 26: 1086–7.

    PubMed  CAS  Google Scholar 

  114. Lobo AJ, Foster PN, Sobala GM, Axon ATR. Crohn’s disease in married couples. Lancet 1988; i: 704–5.

    Google Scholar 

  115. Comes MC, Gower-Rousseau C, Colombel JF et al. Inflammatory bowel disease in married couples: 10 cases in Nord Pas de Calais region of France and Liege county of Belgium. Gut 1994; 35: 1316–18.

    PubMed  CAS  Google Scholar 

  116. van Kruiningen HJ, Colombel JF, Cartun RW et al. An indepth study of Crohn’s disease in two French families. Gastroenterology 1993; 104: 351 60.

    PubMed  Google Scholar 

  117. Cave DR, Freedman LS. Seasonal variations in the clinical presentation of Crohn’s disease and ulcerative colitis. Int J Epidemiol 1975; 4: 317–20.

    Google Scholar 

  118. Myszor M, Calam J. Seasonality of ulcerative colitis. Lancet 1984; 2: 522 3.

    PubMed  Google Scholar 

  119. Sellu DR. Seasonal variation in onset of exacerbations of ulcerative proctocolitis. J R Coll Surg Edinb 1986; 31: 158–60.

    PubMed  CAS  Google Scholar 

  120. Tysk C, Jarnerot G. Seasonal variation in exacerbations of ulcerative colitis. Scand J Gastroenterol. 1993; 28: 95 6.

    PubMed  Google Scholar 

  121. Moum B, Aadland E, Ekbom A, Vatn MH. Seasonal variations in the onset of ulcerative colitis. Gut 1996; 38: 376 8.

    PubMed  Google Scholar 

  122. Morgan KL. Johne’s and Crohn’s. Chronic inflammatory bowel disease of infectious aetiology? Lancet 1987; 1i: 1017–19.

    Google Scholar 

  123. Mayberry JF, Hitchens RAN. Distribution of Crohn’s disease in Cardiff. Soc Sci Med 1978; 12: 137–8.

    PubMed  CAS  Google Scholar 

  124. Hermon-Taylor J. Causation of Crohn’s disease: the impact of clusters. Gastroenterology 1993; 104: 643–6.

    PubMed  CAS  Google Scholar 

  125. Van Kruiningen HJ. Lack of support for a common etiology in Johne’s disease of animals and Crohn’s disease in humans. Inflam Bowel Dis 1999; 5: 183–91.

    Article  Google Scholar 

  126. Afdhal NH, Long A, Lennon J, Crowe J, O’Donoghue DP. Controlled trial of antimycobacterial therapy in Crohn’s disease. Clofazimine versus placebo. Dig Dis Sci 1991; 36: 449–53.

    PubMed  CAS  Google Scholar 

  127. Rutgeerts P, Geboes K, Vantrappen G et al. Rifabutin and ethambutol do not help recurrent Crohn’s disease in the neoterminal ileum. J Clin Gastroenterol 1992; 15: 24–8.

    PubMed  CAS  Google Scholar 

  128. Liu Y, van Kruiningen HJ, West AB, Cartun RW, Cortot A, Colombel JF. Immunocytochemical evidence of Listeria, Escherichia coli, and Streptococcus antigens in Crohn’s disease. Gastroenterology 1995; 108: 1396–404.

    PubMed  CAS  Google Scholar 

  129. Kangro HO, Chong SK, Hardiman A, Heath RB, Walker-Smith JA. A prospective study of viral and Mycoplasma infections in chronic inflammatory bowel disease. Gastroenterology 1990; 98: 549–53.

    PubMed  CAS  Google Scholar 

  130. Ekbom A, Daszak P, Kraaz W, Wakefield AJ. Crohn’s disease after in-utero measles virus exposure. Lancet 1996; 348: 515–17.

    PubMed  CAS  Google Scholar 

  131. North CS, Clouse RE, Spitznagel EL, Alpers DH. The relation of ulcerative colitis to psychiatric factors: a review of findings and methods. Am J Psychiatry 1990; 147: 974–81.

    PubMed  CAS  Google Scholar 

  132. Peck OC, Wood JD. Brain-gut interactions in ulcerative colitis. Gastroenterology 2000; 118: 807–8.

    PubMed  CAS  Google Scholar 

  133. Rutgeerts P, D’Haens G, Hiele M, Geboes K, Vantrappen G. Appendectomy protects against ulcerative colitis. Gastroenterology 1994; 106: 1251–3.

    PubMed  CAS  Google Scholar 

  134. Duggan AE, Usmani I, Neal KR, Logan RF. Appendicectomy, childhood hygiene, Helicobacter pylori status, and risk of inflammatory bowel disease: a case control study. Gut 1998; 43: 494–8.

    Article  PubMed  CAS  Google Scholar 

  135. Mizoguchi A, Mizoguchi E, Chiba C, Bhan AK. Role of appendix in the development of inflammatory bowel disease in TCR-α mutant mice. J Exp Med 1996; 184: 707–15.

    PubMed  CAS  Google Scholar 

  136. Ekbom A. Appendicectomy and childhood hygiene: different sides of the same coin? Gut 1998; 43: 451.

    Article  PubMed  CAS  Google Scholar 

  137. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy and protection against ulcerative colitis. N Engl J Med 2001; 344: 808–14.

    PubMed  CAS  Google Scholar 

  138. Blomqvist P, Ljung H, Nyrén O, Ekbom A. Appendectomy in Sweden 1989–1993 assessed by the Inpatient Register. J Clin Epidemiol 1998; 51: 859–65.

    PubMed  CAS  Google Scholar 

  139. Barker DJP, Morris JA. Acute appendicitis, bathrooms, and diet in Britain and Ireland. Br Med J 1988; 296: 953 8.

    Google Scholar 

  140. Bjorksten B. Environment and infant immunity. Proc Nutr Soc 1999; 58: 729 32.

    PubMed  Google Scholar 

  141. Whorwell PJ, Holdstock G, Whorwell GM, Wright R. Bottle feeding, early gastroenteritis and inflammatory bowel disease. Br Med J 1979; 1: 382.

    PubMed  CAS  Google Scholar 

  142. Koletzko S, Griffiths A, Corey M, Smith C, Sherman P. Infant feeding practices and ulcerative colitis in childhood. Br Med J 1991; 302: 1580 1.

    Google Scholar 

  143. Koletzko S, Sherman P, Corey M, Griffiths A, Smith C. Role of infant feeding practices in development of Crohn’s disease in childhood. Br Med J 1989; 298: 1617 18.

    Google Scholar 

  144. Bergstrand O, Hellers G. Breast-feeding during infancy in patients who later develop Crohn’s disease. Scand J Gastroenterol 1983; 18: 903–6.

    Article  PubMed  CAS  Google Scholar 

  145. Gent AE, Hellier MD, Grace RH, Swarbick ET, Coggon D. Inflammatory bowel disease and domestic hygiene in infancy. Lancet 1994; 343: 766–7.

    PubMed  CAS  Google Scholar 

  146. Persson PG, Leijonmarck CE, Bernell O, Hellers G, Ahlbom A. Risk indicators for inflammatory bowel disease. Int J Epidemiol 1993; 22: 268–72.

    PubMed  CAS  Google Scholar 

  147. Montgomery SM, Pounder RE, Wakefield AJ. Infant mortality and the incidence of inflammatory bowel disease. Lancet 1997; 349: 472–3.

    PubMed  CAS  Google Scholar 

  148. Ekbom A, Zack M, Adami HO, Helmick C. Is there clustering of inflammatory bowel disease at birth? Am J Epidemiol 1991; 134: 876–86.

    PubMed  CAS  Google Scholar 

  149. Wakefield AJ, Ekbom A, Dhillon AP, Pittilo RM, Pounder RE. Crohn’s disease: pathogenesis and persistent measles virus infection. Gastroenterology 1995; 108: 911–16.

    PubMed  CAS  Google Scholar 

  150. Montgomery SM, Morris DL, Pounder RE, Wakefield AJ. Paramyxovirus infections in childhood and subsequent inflammatory bowel disease. Gastroenterology 1999; 116: 796–803.

    PubMed  CAS  Google Scholar 

  151. Morita N, Toki S, Hirohashi T et al. Incidence and prevalence of inflammatory bowel disease in Japan: nationwide epidemiological survey during the year 1991. J Gastroenterol 1995; 30(Suppl. 8): 1–4.

    PubMed  Google Scholar 

  152. Yoon CM, Kim SB, Park IJ et al. Clinical features of Crohn’s disease in Korea. Gastroenterol Jpn 1988; 23: 576–81.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine at Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden

    Anders Ekbom (Professor)

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  1. Anders Ekbom
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Editors and Affiliations

  1. Cedars-Sinai IBD Center, Los Angeles, CA, USA

    Stephan R. Targan  & Loren C. Karp  & 

  2. Cork University Hospital, Cork, Ireland

    Fergus Shanahan

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© 2003 Kluwer Academic Publishers

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Ekbom, A. (2003). The changing faces of Crohn’s disease and ulcerative colitis. In: Targan, S.R., Shanahan, F., Karp, L.C. (eds) Inflammatory Bowel Disease: From Bench to Bedside. Springer, Boston, MA. https://doi.org/10.1007/0-387-25808-6_2

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  • DOI: https://doi.org/10.1007/0-387-25808-6_2

  • Publisher Name: Springer, Boston, MA

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