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ADAM9

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The ADAM Family of Proteases

Part of the book series: Proteases in Biology and Disease ((PBAD,volume 4))

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Abstract

ADAM9 (meltrin γ, MDC9) was first described by Yagami et al. (1995) as one of fertilin-like my m oblast-expressed gene products. Although only meltrin α (ADAM12) is required for myotube formation, meltrins β (ADAM19) and γ are involved in various cellular processes. The sequence of the predicted ADAM9 contains several domains like other ADAMs: a signal peptide, a zinc-dependent metalloprotease domain, a disintegrin-like domain, a cysteine-rich domain, an epidermal growth factor (EGF)-like domain, a transmembrane domain, and a C-terminal cytoplasmic tail. ADAM9 is predicted to be an active metalloprotease due to a catalytic site consensus sequence HEXXH in its metalloprotease domain.

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Author information

Authors and Affiliations

  1. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan

    Shoichi Ishiura

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  1. Shoichi Ishiura
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Editors and Affiliations

  1. University of Leeds, UK

    Nigel M. Hooper

  2. University of Magdeburg, Germany

    Uwe Lendeckel

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© 2005 Springer

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Ishiura, S. (2005). ADAM9. In: Hooper, N.M., Lendeckel, U. (eds) The ADAM Family of Proteases. Proteases in Biology and Disease, vol 4. Springer, Boston, MA. https://doi.org/10.1007/0-387-25151-0_4

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