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Metastasis suppression in prostate cancer

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Prostate Cancer: New Horizons in Research and Treatment

Part of the book series: Developments in Oncology ((DION,volume 81))

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Abstract

Due to a lack of effective treatments, the development of metastases remains the most lethal aspect of prostate cancer. In order to help overcome this problem there has been an ongoing effort to develop strategies for early intervention. This includes the development of strategies that allow histologic lesions and disseminated cells that are highly likely to cause metastatic disease to be distinguished from those that are not, as well as therapeutic approaches to specifically target bone metastases. Such approaches will be expedited by the identification of genes and signaling cascades that regulate metastatic growth. Genes that specifically suppress metastasis are strong candidates for these studies. This review will focus on metastasis-suppressor genes that have been identified functionally, particularly those found to play a role in prostate cancer, and discuss how the identification and study of these genes has influenced our overall understanding of the metastatic process.

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Author information

Authors and Affiliations

  1. The University of Chicago Urology Research Laboratory, Pennsylvania State College of Medicine, PA, USA

    Erich B. Jaeger & Carrie W. Rinker-Schaeffer

  2. The Jake Gittlen Cancer Research Institute, Pennsylvania State College of Medicine, PA, USA

    Rajeev S. Samant

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  1. Erich B. Jaeger
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  2. Rajeev S. Samant
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  3. Carrie W. Rinker-Schaeffer
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Editors and Affiliations

  1. The Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA

    Michael L. Cher

  2. Wayne State University School of Medicine, Detroit, MI, USA

    Avraham Raz  & Kenneth V. Honn  & 

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© 2002 Kluwer Academic Publishers

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Jaeger, E.B., Samant, R.S., Rinker-Schaeffer, C.W. (2002). Metastasis suppression in prostate cancer. In: Cher, M.L., Raz, A., Honn, K.V. (eds) Prostate Cancer: New Horizons in Research and Treatment. Developments in Oncology, vol 81. Springer, Boston, MA. https://doi.org/10.1007/0-306-48143-X_9

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  • DOI: https://doi.org/10.1007/0-306-48143-X_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7352-6

  • Online ISBN: 978-0-306-48143-7

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