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Geohelminths, HIV/AIDS and TB

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The Geohelminths: Ascaris, Trichuris and Hookworm

Part of the book series: World Class Parasites ((WCPA,volume 2))

Conclusions

We have presented the results of the interaction between helminthic infection, HIV and tuberculosis, with a major emphasis on the immune changes accompanying helminthic infections and their implications for these interactions. The major common denominator to these interactions is the immune activation and the skewed cytokine profile which the helminthic infections cause and which markedly affects the ability of the host to cope with either HIV or tuberculosis. The most important conclusion that can be drawn at this stage, is that the suppression of helminthic infections, may have a major impact on the spread and progression of HIV infection and tuberculosis, as well as on the success of protective vaccines against both. This conclusion applies particularly to the developing countries, where all these infections are so common and where access to antiretroviral therapy is not available. It is however critical to show if suppression of helminthic infections leads to decreased incidence of HIV and tuberculosis, will it be accompanied by decreased HIV viral load and progression of the infection, and just as importantly, whether generation of protective immunity to HIV and tuberculosis will be improved after deworming. Since the public health case for deworming has already been demonstrated by its effectiveness in enhancing the development of children (see Chapters 3 and 4), large scale eradication of helminthic infections throughout the developing world in the context of the AIDS and tuberculosis epidemics, should be seriously considered and implemented, even if the consequences are only probable or partially positive.

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References

  • ABBAS, A. K., MURPHY, K.M. & SHER, A. (1996). Functional diversity of helper T lymphocytes. Nature 383, 787–793.

    Article  PubMed  CAS  Google Scholar 

  • ACTOR, J.K, SHIRAI, M., KULLBERG, M.C., BULLER, R.M, SHER, A. & BERZOFSKY, J.A. (1993). Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proceedings of the National Academy of Sciences (USA) 90, 948–952.

    CAS  Google Scholar 

  • ADAMS, J.F., SCHOLVINCK, E.H., GIE, R.P., POTTER, P.C., BEYERS, N. & Beyers, A.D. (1999). Decline in total serum IgE after treatment for tuberculosis. Lancet 353, 2030–2033.

    Article  PubMed  CAS  Google Scholar 

  • ANZALA, O.A., NAGELKERKE, N.J., BWAYO, J.J., HOLTON, D., MOSES, S., NGUGI, E.N., NDINYA-ACHOLA, J.O. & PLUMMER, F.A. (1995). Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection. Journal of Infectious Diseases 171, 686–689.

    PubMed  CAS  Google Scholar 

  • AYASH-RASHKOVSKY, M., WEISMAN, Z, ZLOTNIKOV, S., RAZ, E., BENTWICH, Z. & BORKOW, G. (2001). Induction of antigen-specific Th1-biased immune responses by plasmid DNA in schistosoma-infected mice with a preexistent dominant Th2 immune profile. Biochemical and Biophysical Research Communications 282, 1169–1176.

    Article  PubMed  CAS  Google Scholar 

  • BENTWICH, Z., KALINKOVICH, A. & WEISMAN, Z. (1995). Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunology Today 16, 187–191.

    Article  PubMed  CAS  Google Scholar 

  • BENTWICH, Z. KALINKOVICH, A., WEISMAN, Z., BORKOW, G., BEYERS, N. & BEYERS, A.D. (1999). Can eradication of helminthic infections change the face of AIDS and tuberculosis? Immunology Today 20, 485–487.

    Article  PubMed  CAS  Google Scholar 

  • BENTWICH, Z. KALINKOVICH, A., WEISMAN, Z. & GROSSMAN, Z. (1998). Immune activation in the context of HIV infection. Clinical and Experimental Immunology 111, 1–2.

    Article  PubMed  CAS  Google Scholar 

  • BENTWICH, Z., WEISMAN, Z., GROSSMAN, Z., GALAI, N. & KALINKOVICH, A. (1997). Pathogenesis of AIDS in Africa — Lessons from the Ethiopian immigrants in Israel. Immunologist 5, 211–226.

    Google Scholar 

  • BENTWICH, Z. WEISMAN, Z., MOROZ, C., BAR-YEHUDA, S. & KALINKOVICH, A. (1996). Immune dysregulation in Ethiopian immigrants in Israel: relevance to helminth infections? Clinical and Experimental Immunology 103, 239–243.

    Article  PubMed  CAS  Google Scholar 

  • BEYERS, N. GIE, R.P., ZIETSMAN, H.L., KUNNEKE, M., HAUMAN, J., TATLEY, M. & DONALD, P.R. (1996). The use of a geographical information system to evaluate the distribution of tuberculosis in a high-incidence community. South African Medical Journal 86, 40–1, 44.

    PubMed  CAS  Google Scholar 

  • BORKOW, G. LENG, Q., WEIZMAN, Z., STEIN, M., GALAI, N., KALINKOVICH, A. & BENTWICH, Z. (2000). Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergy. Journal of Clinical Investigation 106, 1053–1060.

    PubMed  CAS  Google Scholar 

  • BORKOW, G. WEIZMAN, Z., LENG, Q., STEIN, M., KALINKOVICH, A., WOLDAY, D. & BENTWICH, Z. (2001). Helminths, Human Immunodeficiency Virus and Tuberculosis. Scandinavian Journal of Infectious Diseases In press.

    Google Scholar 

  • BOYER, J.D., WANG, B., UGEN, K.E., AGADJANYAN, M., JAVADIAN, A, FROST, P., DANG, K., Carrano, R.A., Ciccarelli, R., Coney, L., Williams, W.V. & Weiner, D.B. (1996). In vivo protective anti-HIV immune responses in non-human primates through DNA immunization. Journal of Medical Primatology 25, 242–250.

    PubMed  CAS  Google Scholar 

  • BUNDY, D.A. & DE SILVA, N.R. (1998). Can we deworm this wormy world? British Medical Bulletin 54, 421–432.

    PubMed  CAS  Google Scholar 

  • BUNDY, D.A., SHER, A. & MICHAEL, E. (2000). Good worms or bad worms: Do worm infections affect the epidemiological patterns of other diseases? Parasitology Today 16, 273–274.

    PubMed  CAS  Google Scholar 

  • CHIARAMONTE, M.G., Hesse, M., Cheever, A.W. & Wynn, T.A. (2000). CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-inducedpathology by an IL-12-independent mechanism. Journal of Immunology 164, 973–985.

    CAS  Google Scholar 

  • CLERICI, M. & SHEARER, G.M. (2001). The TH1-TH2 hypothesis of HIV infection: new insights. Immunology Today, 12, 575–581.

    Google Scholar 

  • CLERICI, M., GIORGI, J.V., CHOU, C.C., GUDEMAN, V.K., ZACK, J.A., GUPTA, P., HO, H.N., NISHANIAN, P.G., BERZOFSKY, J.A. & SHEARER, G.M. (1992). Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1, Journal of Infectious Diseases 165, 1012–1019.

    PubMed  CAS  Google Scholar 

  • CLERICI, M., LEVIN, J.M., KESSLER, H.A., HARRIS, A., BERZOFSKY, J.A., LANDAY, A.L. & SHEARER, G.M. (1994). HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. Journal of the American Microbiological Association 271, 42–46.

    CAS  Google Scholar 

  • CLERICI, M. & SHEARER, G.M. (1993). A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunology Today 14, 107–111.

    Article  PubMed  CAS  Google Scholar 

  • COOVADIA, H. M., JEENA, P. & WILKINSON, D. (1998). Childhood human immunodeficiency virus and tuberculosis co-infections: reconciling conflicting data. International Journal of Tuberculosis and Lung Disease 2, 844–851.

    PubMed  CAS  Google Scholar 

  • CORREA-OLIVEIRA, R., MALAQUIAS, L.C., FALCAO, P.L., VIANA, I.R., BAHIA-OLIVEIRA, L.M, SILVEIRA, A.M., FRAGA, L.A., PRATA, A., COFFMAN, R.L., LAMBERTUCCI, J.R., CUNHA-MELO, J.R., MARTINS-FILHO, O.A., WILSON, R.A. & GAZZINELLI, G. (1998). Cytokines as determinants of resistance and pathology in human Schistosoma mansoni infection. Brazilian Journal of Medical Biological Research 31, 171–177.

    CAS  Google Scholar 

  • DAVIS, H.L., (2000). Use of CpG DNA for enhancing specific immune responses. Current Topics in Microbiology and Immunology 247, 171–183.

    PubMed  CAS  Google Scholar 

  • DE MARIA, A., CIRILLO, C. & MORETTA, L. (1994). Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1-infected mothers. Journal of Infectious Diseases 170, 1296–1299.

    PubMed  Google Scholar 

  • DE SILVA, N.R., CHAN, M.S. & BUNDY, D.A. (1997). Morbidity and mortality due to ascariasis: re-estimation and sensitivity analysis of global numbers at risk. Tropical Medicine and International Health 2, 519–528.

    PubMed  Google Scholar 

  • DYE, C., SCHEELE, S., DOLIN, P., PATHANIA, V. & RAVIGLIONE, M.C. (1999). Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. Journal of the American Microbiological Association 282, 677–686.

    CAS  Google Scholar 

  • DYER, J.R., KAZEMBE, P., VERNAZZA, P.L., GILLIAM, B.L., MAIDA, M., ZIMBA, D., HOFFMAN, I.F., ROYCE, R.A., SCHOCK, J.L., FISCUS, S.A., COHEN, M.S. & ERON, J.J., JR. (1998). High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa. Journal of Infectious Diseases 177, 1742–1746.

    Article  PubMed  CAS  Google Scholar 

  • ELIAS, D., ASHMARE, G., PETROS, B. & BRITTON, S. (2001). Deworming and resistance against TB. Ethiopian Medicine Journal 37, 3–7.

    Google Scholar 

  • ELIAS, D., WOLDAY, D., AKUFFO, H., PETROS, B., BRONNER, U. & BRITTON, S. (2001). Effect of deworming on human T cellresponses to mycobacterial antigens in helminth-exposed individuals before and after bacille Calmette-Guerin (BCG) vaccination. Clinical and Experimental Immunology 123, 219–225.

    Article  PubMed  CAS  Google Scholar 

  • ELSON, L.H., SHAW, S., VAN LIER R.A. & NUTMAN, T.B. (1994). T cell subpopulation phenotypes in filarial infections: CD27 negativity defines a population greatly enriched for Th2 cells. International Immunology 6, 1003–1009.

    PubMed  CAS  Google Scholar 

  • FALCAO, P.L., MALAQUIAS, L.C., MARTINS-FILHO, O.A., SILVEIRA, A.M., PASSOS, V.M., PRATA, A., GAZZINELLI, G., COFFMAN, R.L. & CORREA-OLIVEIRA, R. (1998). Human Schistosomiasis mansoni: IL-10 modulates the in vitro granuloma formation. Parasite Immunology 20, 447–454.

    Article  PubMed  CAS  Google Scholar 

  • FOMSGAARD, A. (1999). HIV-1 DNA vaccines. Immunology Letters 65, 127–131.

    Article  PubMed  CAS  Google Scholar 

  • FOWKE, K.R., NAGELKERKE, N.J., KIMANI, J., SIMONSEN, J.N., ANZALA, A.O., BWAYO, J.J., MACDONALD, K.S., NGUGI, E.N. & PLUMMER, F.A. (1996). Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet 348, 1347–1351.

    Article  PubMed  CAS  Google Scholar 

  • GHOSH, M.K., GHOSH, A.K., ADDY, M., NANDY, A. & GHOSE, A.C. (1996). Subpopulations of T lymphocytes in the peripheral blood and lymph nodes of Indian kala-azar patients. Medical Microbiology and Immunology (Berlin) 185, 183–187.

    CAS  Google Scholar 

  • GOPINATH, R., OSTROWSKI, M., JUSTEMENT, S.J., FAUCI, A.S. & NUTMAN, T.B. (2000). Filarial infections increase susceptibility to human immunodeficiency virus infection in peripheral blood mononuclear cells in vitro. Journal of Infectious Diseases 182, 1804–1808.

    Article  PubMed  CAS  Google Scholar 

  • GURUNATHAN, S., KLINMAN, D. M. & SEDER, R. A. (2000). DNA vaccines: immunology, application, and optimization. Annual Reviews in Immunology 18, 927–974.

    CAS  Google Scholar 

  • HARBOE, M. (1998). Protective immunity to intracellular parasites—a focus for vaccine research and a challenge to immunization programmes. Developments in Biological Standardization (Basel) 92, 145–147.

    CAS  Google Scholar 

  • HEILMAN, C.A. & BALTIMORE, D. (1998). HIV vaccines — where are we going? Nature Medicine 4, 532–534.

    Article  PubMed  CAS  Google Scholar 

  • INFANTE-DUARTE, C. & KAMRADT, T. (1999). Thl/Th2 balance in infection. Seminars in Immunopathology 21, 317–338.

    CAS  Google Scholar 

  • JEAN, S.S., REED, G.W., VERDIER, R.I., PAPE, J.W., JOHNSON, W.D. & WRIGHT, P.F. (1997). Clinical manifestations of human immunodeficiency virus infection in Haitian children. Pediatric Infectious Disease Journal 16, 600–606.

    PubMed  CAS  Google Scholar 

  • JOINT UNITED NATIONS PROGRAMME ON HIV/AIDS AND WORLD HEALTH ORGANIZATION. (2001). Report on the global HIV/AIDS epidemic.

    Google Scholar 

  • KALINKOVICH, A., BORKOW, G., WEISMAN, Z., TSIMANIS, A., STEIN, M. & BENTWICH, Z. (2001). Increased ccr5 and cxcr4 expression in Ethiopians living in Israel: environmental and constitutive factors. Clinical Immunology 100, 107–117.

    Article  PubMed  CAS  Google Scholar 

  • KALINKOVICH, A., WEISMAN, Z., GREENBERG, Z., NAHMIAS, J., EITAN, S., STEIN, M. & BENTWICH, Z. (1998). Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection. Clinical and Experimental Immunology 114, 414–421.

    Article  PubMed  CAS  Google Scholar 

  • KALINKOVICH, A., WEISMAN, Z., LENG, Q., BORKOW, G., STEIN, M., GREENBERG, Z., ZLOTNIKOV, S., EITAN, S. & BENTWICH, Z. (1999). Increased CCR5 expression with decreased beta chemokine secretion in Ethiopians: relevance to AIDS in Africa. Journal of Human Virology 2, 283–289.

    PubMed  CAS  Google Scholar 

  • KRIEG, A.M. & DAVIS, H.L. (2001). Enhancing vaccines with immune stimulatory CpG DNA. Current Opinions in Molecular Therapy 3, 15–24.

    CAS  Google Scholar 

  • LANGLADE-DEMOYEN, P., NGO-GIANG-HUONG, N., FERCHAL, F. & OKSENHENDLER, E. (1994). Human immunodeficiency virus(HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients. Journal of Clinical Investigation 93, 1293–1297.

    PubMed  CAS  Google Scholar 

  • LEROY, E., BAIZE, S., WAHL, G., EGWANG, T.G. & GEORGES, A.J. (1997). Experimental infection of a nonhuman primate with Loa loa induces transient strong immune activation followed by peripheral unresponsiveness of helper T cells. Infection and Immunity 65, 1876–1882.

    PubMed  CAS  Google Scholar 

  • LOONEY, D.J. (1994). Immune responses to human immunodeficiency virus type 1 in exposed but uninfected individuals: protection or chance? Journal of Clinical Investigation 93, 920.

    PubMed  CAS  Google Scholar 

  • MAGGI, E., MAZZETTI, M., RAVINA, A., ANNUNZIATO, F., DE CARLI, M., PICCINNI, M.P., MANETTI, R., CARBONARI, M., PESCE, A.M. & DEL PRETE, G. (1994). Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells. Science 265, 244–248.

    PubMed  CAS  Google Scholar 

  • MAIZELS, R.M., BUNDY, D.A., SELKIRK, M.E., SMITH, D.F. & ANDERSON, R.M. (1993). Immunological modulation and evasion by helminth parasites in human populations. Nature 365, 797–805.

    Article  PubMed  CAS  Google Scholar 

  • MAIZELS, R.M. & HOLLAND, M.J. (1998). Parasite immunology: pathways for expelling intestinal helminths. Current Biology 8, R711–R714.

    Article  PubMed  CAS  Google Scholar 

  • MAIZELS, R.M., KURNIAWAN, A., SELKIRK, M.E. & YAZDANBAHSH, M. (1991). Immune responses to filarial parasites. Immunology Letters 30, 249–254.

    Article  PubMed  CAS  Google Scholar 

  • MALAQUIAS, L.C., FALCAO, P.L., SILVEIRA, A.M., GAZZINELLI, G., PRATA, A., COFFMAN, R.L., PIZZIOLO, V., SOUZA, C.P., COLLEY, D.G. & CORREA-OLIVEIRA, R. (1997). Cytokine regulation of human immune response to Schistosoma mansoni: analysis of the roleof IL-4, IL-5and IL-10 on peripheral blood mononuclear cell responses. Scandinavian Journal of Immunology 46, 393–398.

    Article  PubMed  CAS  Google Scholar 

  • McMICHAEL, A.J. & ROWLAND-JONES, S.L. (2001). Cellular immune responses to HIV. Nature 410, 980–987.

    Article  PubMed  CAS  Google Scholar 

  • MESSELE, T., ABDULKADIR, M., FONTANET, A.L., PETROS, B., HAMANN, D., KOOT, M., ROOS, M.T., SCHELLEKENS, P.T., MIEDEMA, F. & RINKE DE WIT, T.F. (1999). Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts. Clinical and Experimental Immunology 115, 443–450.

    Article  PubMed  CAS  Google Scholar 

  • MOSMANN, T.R. & COFFMAN, R.L. (1989). TH1 & TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Reviews in Immunology 7, 145–173.

    Article  CAS  Google Scholar 

  • OHRUI, T., ZAYASU, K., SATO, E., MATSUI, T., SEKIZAWA, K. & SASAKI, H. (2000). Pulmonary tuberculosis and serum IgE. Clinical and Experimental Immunology 122, 13–15.

    Article  PubMed  CAS  Google Scholar 

  • OSCHERWITZ, T., TULSKY, J.P., ROGER, S., SCIORTINO, S., ALPERS, A., ROYCE, S. & LO, B. (1997). Detention of persistently nonadherent patients with tuberculosis. Journal of the American Microbiological Association 278, 843–846.

    CAS  Google Scholar 

  • OTTENHOFF, T.H., KUMARARATNE, D. & CASANOVA, J.L. (1998). Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria. Immunology Today 19, 491–494.

    Article  PubMed  CAS  Google Scholar 

  • PEARCE, E.J., LA FLAMME, A., SABIN, E. & BRUNET, L.R. (1998). The initiation and function of Th2 responses during infection with Schistosoma mansoni. Advances in Experimental Medical Biology 452, 67–73.

    CAS  Google Scholar 

  • PINTO, L.A., SULLIVAN, J., BERZOFSKY, J.A., CLERICI, M., KESSLER, H.A., LANDAY, A.L. & SHEARER, G.M. (1995). ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids. Journal of Clinical Investigation 96, 867–876.

    Article  PubMed  CAS  Google Scholar 

  • PIOT, P., BARTOS, M., GHYS, P.D., WALKER, N. & SCHWARTLANDER, B. (2001). The global impact of HIV/AIDS. Nature 410, 968–973.

    Article  PubMed  CAS  Google Scholar 

  • PLUMMER, F.A., BALL, T.B., KIMANI, J. & FOWKE, K.R. (1999). Resistance to HIV-1 infection among highly exposed sex workers in Nairobi: what mediates protection and why does it develop? Immunological Letters 66, 27–34.

    CAS  Google Scholar 

  • PREISER, W., CACOPARDO, B., NIGRO, L., BRANER, J., NUNNARI, A., DOERR, H.W. & WEBER, B. (1996). Immunological findings in HIV-Leishmania coinfection. Intervirology 39, 285–288.

    PubMed  CAS  Google Scholar 

  • PUTKONEN, P., MAKITALO, B., BOTTIGER, D., BIBERFELD, G. & THORSTENSSON, R. (1997). Protection of human immunodeficiency virus type 2-exposed seronegative macaques from mucosal simian immunodeficiency virus transmission. Journal of Virology 71. 4981–4984.

    PubMed  CAS  Google Scholar 

  • RAZ, E., TIGHE, H., SATO, Y., CORR, M., DUDLER, J.A., ROMAN M., SWAIN, S.L., SPIEGELBERG, H.L. & CARSON, D.A. (1996). Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proceedings of the National Academy of Science (USA) 93, 5141–5145.

    CAS  Google Scholar 

  • ROMAGNANI, S. & MAGGI, E. (1994). Th1 versus Th2 responses in AIDS. Current Opinions in Immunology 6, 616–622.

    CAS  Google Scholar 

  • ROMAGNANI, S., MAGGI, E. & DEL PRETE, G. (1994). HIV can induce a TH1 to TH0 shift, and preferentially replicates in CD4+ T-cell clones producing TH2-type cytokines. Research in Immunology 145, 611–617.

    Article  PubMed  CAS  Google Scholar 

  • ROMAN, M., MARTIN-OROZCO, E., GOODMAN, J.S., NGUYEN, M.D., SATO, Y., RONAGHY, A., KORNBLUTH, R.S., RICHMAN, D.D., CARSON, D.A. & RAZ, E. (1997). Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nature Medicine 3, 849–854.

    Article  PubMed  CAS  Google Scholar 

  • SABIN, E.A., ARAUJO, M.I., CARVALHO, E.M. & PEARCE, E.J. (1996). Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni. Journal of Infectious Diseases 173, 269–272.

    PubMed  CAS  Google Scholar 

  • SCANGA, C.B. & LE GROS, G. (2000). Development of an asthma vaccine: research into BCG. Drugs 59, 1217–1221.

    PubMed  CAS  Google Scholar 

  • SHAPIRA-NAHOR, O., KALINKOVICH, A., WEISMAN, Z., GREENBERG, Z., NAHMIAS, J., SHAPIRO, M., PANET, A. & BENTWICH, Z. (1998). Increased susceptibility to HIV-1 infection of peripheral blood mononuclear cells from chronically immune-activated individuals. AIDS 12, 1731–1733.

    PubMed  CAS  Google Scholar 

  • SHER, A., GAZZINELLI, R.T., OSWALD, I.P., CLERICI, M., KULLBERG, M., PEARCE, E.J., BERZOFSKY, J.A., MOSMANN, T.R., JAMES, S.L. & MORSE, H.C., III (1992). Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunology Reviews 127, 183–204.

    Article  CAS  Google Scholar 

  • SINGLETON, L., TURNER, M., HASKAL, R., ETKIND, S., TRICARICO, M. & NARDELL, E. (1997). Long-term hospitalization for tuberculosis control. Experience with a medical-psychosocial inpatient unit. Journal of the American Microbiological Association 278, 838–842.

    CAS  Google Scholar 

  • SRIKANTH, P., CASTILLO, R.C., SRIDHARAN, G., JOHN, T.J., ZACHARIAH, A., MATHAI, D. & SCHWARTZ, D.H. (2000). Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India. International Journal of STD and AIDS 11, 49–51.

    Article  PubMed  CAS  Google Scholar 

  • THOMPSON, C.B. & ALLISON, J.P., (1997). The emerging role of CTLA-4 as an immune attenuator. Immunity 7, 445–450.

    Article  PubMed  CAS  Google Scholar 

  • TORRES, M., HERRERA, T., VILLAREAL, H., RICH, E.A. & SADA, E. (1998). Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis. Infection and Immunity 66, 176–180.

    PubMed  CAS  Google Scholar 

  • VILLA, O.F. & KUHN, R.E. (1996). Mice infected with the larvae of Taenia crassiceps exhibit a Th2-like immune response with concomitant anergy and downregulation of Th1 — associated phenomena. Parasitology 112, 561–570.

    Article  PubMed  Google Scholar 

  • WEISMAN, Z., KALINKOVICH, A., BORROW, G., STEIN, M., GREENBERG, Z. & BENTWICH, Z. (1999). Infection by different HIV-1 subtypes (B and C) results in a similar immune activation profile despite distinct immune backgrounds. Journal of Acquired Immune Deficiency Syndrome 21, 157–163.

    CAS  Google Scholar 

  • WOLDAY, D., BERHE, N., AKUFFO, H. & BRITTON, S. (1999). Leishmania-HIV interaction: immunopathogenic mechanisms. Parasitology Today 15, 182–187.

    Article  PubMed  CAS  Google Scholar 

  • WOLDAY, D. MAAYAN, S., MIRIAM, G. and BENTWICH, Z. (2000). Eradication of helminthic infection decreases HIV plasma viral load in dually-infected people. Abstract 157. 7th Conference on Retrovirus and Opportunistic Infections. San Francisco, USA.

    Google Scholar 

  • YAZDANBAKHSH, M. (1999). Common features of T cell reactivity in persistent helminth infections: lymphatic filariasis and schistosomiasis. Immunology Letters 65, 109–115.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. R. Ben-Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot, 87100, Israel

    Gadi Borkow & Zvi Bentwich

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  1. Gadi Borkow
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  2. Zvi Bentwich
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Editors and Affiliations

  1. Department of Zoology, University of Dublin, Dublin

    Celia V. Holland

  2. Division of Environmental and Evolutionary Biology Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK

    Malcolm W. Kennedy

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Borkow, G., Bentwich, Z. (2002). Geohelminths, HIV/AIDS and TB. In: Holland, C.V., Kennedy, M.W. (eds) The Geohelminths: Ascaris, Trichuris and Hookworm. World Class Parasites, vol 2. Springer, Boston, MA. https://doi.org/10.1007/0-306-47383-6_16

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  • DOI: https://doi.org/10.1007/0-306-47383-6_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-7557-9

  • Online ISBN: 978-0-306-47383-8

  • eBook Packages: Springer Book Archive

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