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Process research toward scale-up and industrial preparation of RPR 109891 (Klerval™)

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Peptides for the New Millennium

Part of the book series: American Peptide Symposia ((APSY,volume 6))

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References

  1. “Antithrombotic Azacycloalkylalkanoyl Peptides and Pseudopeptides,” U.S. Patent Applications 08/138,820 (1993), 08/628,648 (1994), 08/476,750 (1995), and 09/137,998 (1997).

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  2. “Process for the Preparation of Azacycloalkylalkanoyl Pseudotetrapeptides,” U.S. Provisional Patent Application 60/061,719 (1997), PCT Application US98-21326 (1998).

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  3. “Stable Non-hygroscopic Crystalline Form of N-[N-[N-(4-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-L-B-cyclohexyl alanine amide, Intermediates Thereof, Preparation There of and of Antithrombotic Azaalkylalkanoyl Peptides and Pseudopeptides,” U.S. Provisional Patent Application 60/024,284 (1996), PCT Application US97-14756 (1997).

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Author information

Authors and Affiliations

  1. Process Chemistry, Chemical and Pharmaceutical Development, Rhone Poulenc Rorer Pharmaceuticals, Collegeville, PA, 19426, USA

    James J. Mencel, Benoit J. Vanasse, Richard G. Woodward, James P. Sherbine, Robert C. Liu, Diane C. Salazar, Harshavadan C. Shah, Matthew R. Powers, Adam W. Sledeski, Gregory C. Kubiak, David S. Teager, Neville L. Holder, Walter Rodriguez, Simon F. Golec, William L. Studt & Philippe Pitchen

  2. Process Analysis, Chemical and Pharmaceutical Development, Rhone Poulenc Rorer Pharmaceuticals, Collegeville, PA, 19426, USA

    Witold L. Tomasik, Vincent L. Windisch & Michael D. Thompson

  3. Process Technology, Chemical and Pharmaceutical Development, Rhone Poulenc Rorer Pharmaceuticals, Collegeville, PA, 19426, USA

    Anthony T. Gardetto, Geoffrey A. D’Netto & David J. Taube

Authors
  1. James J. Mencel
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  2. Benoit J. Vanasse
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  3. Richard G. Woodward
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  4. James P. Sherbine
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  5. Robert C. Liu
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  6. Diane C. Salazar
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  7. Harshavadan C. Shah
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  8. Matthew R. Powers
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  9. Adam W. Sledeski
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  10. Gregory C. Kubiak
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  11. David S. Teager
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  12. Neville L. Holder
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  13. Walter Rodriguez
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  14. Simon F. Golec
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  15. William L. Studt
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  16. Philippe Pitchen
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  17. Witold L. Tomasik
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  18. Vincent L. Windisch
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  19. Michael D. Thompson
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  20. Anthony T. Gardetto
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  21. Geoffrey A. D’Netto
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  22. David J. Taube
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Editor information

Editors and Affiliations

  1. Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida, USA

    Gregg B. Fields

  2. Department of Microbiology and Immunology, Vanderbilt University Medical School, Nashville, Tennessee, USA

    James P. Tam

  3. Departments of Chemistry and Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, Minnesota, USA

    George Barany

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© 2002 Kluwer Academic Publishers

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Mencel, J.J. et al. (2002). Process research toward scale-up and industrial preparation of RPR 109891 (Klerval™). In: Fields, G.B., Tam, J.P., Barany, G. (eds) Peptides for the New Millennium. American Peptide Symposia, vol 6. Springer, Dordrecht. https://doi.org/10.1007/0-306-46881-6_51

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  • DOI: https://doi.org/10.1007/0-306-46881-6_51

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-6445-0

  • Online ISBN: 978-0-306-46881-0

  • eBook Packages: Springer Book Archive

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