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C-kit-positive gastric metastasis of lobular carcinoma of the breast masquerading as gastrointestinal stromal tumor

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Abstract

A 61-year-old woman with no significant past history underwent gastric biopsies demonstrating a strongly c-kit-positive epithelioid malignancy, initially thought to represent gastrointestinal stromal tumor (GIST). Subsequent clinical and immunohistochemical evaluation proved the neoplasm to represent metastatic lobular carcinoma. This case illustrates that although c-kit is highly specific and sensitive for GIST, its expression may occur in a variety of other neoplasms, some of which morphologically resemble GIST and may present in the gastrointestinal tract as metastases. Therefore, a review of other c-kit-positive lesions is also highlighted.

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Abbreviations

C-kit (c-kit protein, c-kit receptor):

C-kit proto-oncogene/CD117

GIST:

Gastrointestinal stromal tumors

GCDFP-15:

Gross cystic disease fluid protein

GI:

Gastrointestinal

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Author information

Authors and Affiliations

  1. Department of Pathology, University of New Mexico, MSC08 4640, 1 University of New Mexico, Albuquerque, NM, 87131, USA

    Bharathi Vennapusa, Sarah A. Oman & Lisa A. Cerilli

  2. Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico, MSC08 4640, 1 University of New Mexico, Albuquerque, NM, 87131, USA

    Gulshan Parasher

Authors
  1. Bharathi Vennapusa
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  2. Sarah A. Oman
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  3. Gulshan Parasher
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  4. Lisa A. Cerilli
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Corresponding author

Correspondence to Bharathi Vennapusa.

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Vennapusa, B., Oman, S.A., Parasher, G. et al. C-kit-positive gastric metastasis of lobular carcinoma of the breast masquerading as gastrointestinal stromal tumor. Breast Cancer 17, 303–305 (2010). https://doi.org/10.1007/s12282-009-0116-x

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  • DOI: https://doi.org/10.1007/s12282-009-0116-x

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