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Updates in biological therapies for knee injuries: bone

  • Knee: Stem Cells (M Ferretti, Section Editor)
  • Published:
Current Reviews in Musculoskeletal Medicine Aims and scope Submit manuscript

Abstract

Bone is a unique tissue because of its mechanical properties, ability for self-repair, and enrollment in different metabolic processes such as calcium homeostasis and hematopoietic cell production. Bone barely tolerates deformation and tends to fail when overloaded. Fracture healing is a complex process that in particular cases is impaired. Osteoprogenitor cells proliferation, growth factors, and a sound tridimensional scaffold at fracture site are key elements for new bone formation and deposition. Mechanical stability and ample vascularity are also of great importance on providing a proper environment for bone healing. From mesenchymal stem cells delivery to custom-made synthetic scaffolds, many are the biological attempts to enhance bone healing. Impaired fracture healing represents a real burden to contemporary society. Sound basic science knowledge has contributed to newer approaches aimed to accelerate and improve the quality of bone healing.

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Conflict of Interest

M. Kfuri Jr, R. Lara de Freitas, B. B. Batista, R. Salim, M. T. Castiglia, R. A. Tavares, and P. H. Araújo declare that they have no conflict of interest.

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  1. Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor – Hospital das Clinicas – Campus USP Av. Bandeirantes 3900 – 11o andar, 14048-900, Ribeirão Preto, SP, Brazil

    Mauricio Kfuri Jr., Rafael Lara de Freitas, Bruno Bellaguarda Batista, Rodrigo Salim, Marcello Teixeira Castiglia, Ricardo Antonio Tavares & Paulo Henrique Araújo

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  1. Mauricio Kfuri Jr.
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  2. Rafael Lara de Freitas
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Kfuri, M., de Freitas, R.L., Batista, B.B. et al. Updates in biological therapies for knee injuries: bone. Curr Rev Musculoskelet Med 7, 220–227 (2014). https://doi.org/10.1007/s12178-014-9225-z

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