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Chemical standards for ion mobility spectrometry: a review

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International Journal for Ion Mobility Spectrometry

Abstract

Ion mobility spectrometry (IMS), using stand-alone instrumentation and hyphenated with mass spectrometry (IM-MS), has recently undergone significant expansion in the numbers of users and applications, particularly in sectors outside its established user base; predominantly military and security applications. Although several IMS reference standards have been proposed, there are no currently universally recognised reference standards for the calibration and evaluation of mobility spectrometers. This review describes current practices and the literature on chemical standards for validating IMS systems in positive and negative ion modes. The key qualities and requirements an ‘ideal’ reference standard must possess are defined, together with the instrumental and environmental factors such as temperature, electric field, humidity and drift gas composition that may need to be considered. Important challenges that have yet to be resolved are also identified and proposals for future development presented.

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Acknowledgements

The work described in this paper was supported under contract with the UK Department for Innovation, Universities and Skills as part of the National Measurement System Chemical and Biological Metrology programme. We thank Jim Kapron from ThermoFinnigan and Reno DeBono from Smiths Detection.

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Authors and Affiliations

  1. Centre for Analytical Science, Department of Chemistry, Loughborough University, Leicestershire, LE11 3TU, UK

    Gushinder Kaur-Atwal, Victor Bocos-Bintintan, C. L. Paul Thomas & Colin S. Creaser

  2. LGC, Queens Road, Teddington, Middlesex, TW11 0LY, UK

    Gavin O’Connor & Alexander A. Aksenov

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  1. Gushinder Kaur-Atwal
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  2. Gavin O’Connor
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Correspondence to Colin S. Creaser.

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Kaur-Atwal, G., O’Connor, G., Aksenov, A.A. et al. Chemical standards for ion mobility spectrometry: a review. Int. J. Ion Mobil. Spec. 12, 1–14 (2009). https://doi.org/10.1007/s12127-009-0021-1

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