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Langerhans cell histiocytosis of mediastinal node

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Abstract

The predominant clinical and radiological features of Langerhans Cell Histiocytosis (LCH) in children are due to osseous involvement. Extra-osseous disease is far less common, occurring in association with bone disease or in isolation. In the present study, LCH was presumptively diagnosed on Ultrasound guided Fine needle aspiration cytology (FNAC) of the mediastinal lymph node in a 18 month-old child. The diagnosis was confirmed by histological examination of the biopsy material. S-100 protein localization in the LCH cells is often positive on immunohistochemistry.

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Authors and Affiliations

  1. Department of Pathology, Kasturba Medical College, Mangalore, India, 575001

    Urmila N. Khadilkar, Kausalya Kumari Sahoo & Mukta R. Pai

  2. Department of Paediatrics, Kasturba Medical College, Mangalore, India, 575001

    A. T. K. Rao

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  1. Urmila N. Khadilkar
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  2. A. T. K. Rao
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  3. Kausalya Kumari Sahoo
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  4. Mukta R. Pai
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Correspondence to Urmila N. Khadilkar.

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Khadilkar, U.N., Rao, A.T.K., Sahoo, K.K. et al. Langerhans cell histiocytosis of mediastinal node. Indian J Pediatr 75, 294–296 (2008). https://doi.org/10.1007/s12098-008-0064-z

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  • DOI: https://doi.org/10.1007/s12098-008-0064-z

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