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Wegener’s Granulomatosis: The Current View

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Abstract

In the last few years, substantial progress has been achieved in elucidating the pathogenesis of Wegener’s granulomatosis. Several genetic risk factors have been described. The structure of the granuloma and its possible function as ectopic lymphoid tissue have been defined. Furthermore, the consecutive immunopathological reactions leading to induction of PR3-antineutrophil cytoplasmic antibodies (ANCA) and the role of ANCA itself is getting clearer. However, the initial events leading to granuloma formation are still widely unknown. Concerning therapy, the significance of the so-called biological agents (TNF-α-blockers, Rituximab) still has to be defined.

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Authors and Affiliations

  1. Department of Rheumatology, Vasculitis Center UKSH & Rheumaklinik Bad Bramstedt, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Frank Moosig, Peter Lamprecht & Wolfgang L. Gross

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  1. Frank Moosig
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  2. Peter Lamprecht
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  3. Wolfgang L. Gross
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Correspondence to Peter Lamprecht.

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Moosig, F., Lamprecht, P. & Gross, W.L. Wegener’s Granulomatosis: The Current View. Clinic Rev Allerg Immunol 35, 19–21 (2008). https://doi.org/10.1007/s12016-007-8067-5

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  • DOI: https://doi.org/10.1007/s12016-007-8067-5

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