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Coenzyme Q10, Copper, Zinc, and Lipid Peroxidation Levels in Serum of Patients with Chronic Obstructive Pulmonary Disease

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Abstract

Severity of chronic obstructive pulmonary disease (COPD) exacerbation is associated with increased level of copper (Cu), zinc (Zn), and lipid peroxidation (malodialdehyde, MDA). The aim of this study was to investigate the levels of lipid peroxidation, Coenzyme Q10 (CoQ10), Zn, and Cu in the COPD exacerbations. Forty-five patients with COPD acute exacerbation and 45 healthy smokers as control group were used in the study. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were lower in exacerbation group than in control. C- reactive protein levels, white blood cell count, and sedimentation rate were significantly (p < 0.001) higher in patients than in control. CoQ10 level and Cu/Zn ratio was significantly (p < 0.05) lower in patients than in control, although MDA, Cu, and Zn levels were significantly (p < 0.05) higher in patients than in control. Negative correlations were found among MDA, Cu, Zn, FEV1, and FVC values in exacerbation and control subjects (p < 0.05). In conclusion, we observed that oxidative stress in the exacerbation period of COPD patients was increased. The decrease in CoQ10 level and Cu/Zn ratio and elevation in Cu and Zn levels observed in the patients probably result from the defense response of organism and are mediated by inflammatory-like substances.

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Abbreviations

BMI:

Body mass index

COPD:

Chronic obstructive pulmonary disease

Cu:

Copper

CoQ10:

Coenzyme Q10

CRP:

C-reactive protein

FEV1:

Forced expiratory volume in 1 s

FVC:

Forced vital capacity

GOLD:

Global initiation for chronic obstructive lung disease

LP:

Lipid peroxidation

MDA:

Malonyldialdehyde

Zn:

Zinc

WBC:

White blood cell

References

  1. Izquierdo JL, Barcina C, Jimenez J et al (2009) Study of the burden on patients with chronic obstructive pulmonary disease. Int J Clin Pract 63:87–97

    Article  PubMed  CAS  Google Scholar 

  2. Yamamoto C, Yoneda T, Yoshıkawa M et al (1997) Airway inflammation in COPD assessed by sputum levels of interleukin-8. Chest 112:505–510

    Article  PubMed  CAS  Google Scholar 

  3. Cao Z, Ong KC, Eng P et al (2006) Frequent hospital readmissions for acute exacerbation of COPD and their associated factors. Respirology 11:188–195

    Article  PubMed  Google Scholar 

  4. Petruzzelli S, Hietanen E, Bartsch H et al (1990) Pulmonary lipid peroxidation in cigarette smokers and lung cancer patients. Chest 98:930–935

    Article  PubMed  CAS  Google Scholar 

  5. Isik B, Isik RS, Ceylan A et al (2005) Trace elements and oxidative stress in chronic obstructive pulmonary disease. Saudi Med J 26:1882–1885

    PubMed  Google Scholar 

  6. Chang KL, Hung TC, Hsieh BS et al (2006) Zinc at pharmacologic concentrations affects cytokine expression and induces apoptosis of human peripheral blood mononuclear cells. Nutrition 22:465–474

    Article  PubMed  CAS  Google Scholar 

  7. Rahman I, Swarska E, Henry M et al (2000) Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Thorax 55:189–193

    Article  PubMed  CAS  Google Scholar 

  8. Nazıroğlu M (2007) New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose. Neurochem Res 2:1990–2001

    Google Scholar 

  9. Nazıroğlu M (2009) Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy. Neurochem Res 34:2181–2191

    Article  PubMed  Google Scholar 

  10. Calikoglu M, Unlu A, Tamer L et al (2002) The levels of serum vitamin C, malonyldialdehyde and erythrocyte reduced glutathione in chronic obstructive pulmonary disease and in healthy smokers. Clin Chem Lab Med 40:1028–1031

    Article  PubMed  CAS  Google Scholar 

  11. Manrique HA, Gómez FP, Muñoz PA et al (2008) Adenosine 5′-monophosphate in asthma: Gas exchange and sputum cellular responses. Eur Respir J 31:1205–1212

    Article  PubMed  CAS  Google Scholar 

  12. Gurkan AS, Dundar BO (2005) Coenzyme q10. J Fac Pharm 34:129–154

    CAS  Google Scholar 

  13. Global strategy for diagnosis, management, and prevention of COPD. Available at http://www.goldcopd.com/Guidelineitem.asp?l1=2&l2=1&intId=2003. Accessed on 11 August 2010

  14. Anthonisen NR, Manfreda J, Warren W (1987) Antibiotics therapy in exacerbations of chronic obstructive pulmonary disease. Ann Int Med 106:196–204

    PubMed  CAS  Google Scholar 

  15. Esterbauer H, Cheeseman KH (1990) Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hidroxynonenal. Meth Enzymol 186:407–421

    Article  PubMed  CAS  Google Scholar 

  16. Kaplan P, Sebestianová N, Turiaková J et al (1996) Determination of coenzyme Q in human plasma. Physiol Res 45:39–45

    PubMed  CAS  Google Scholar 

  17. Gumral N, Naziroglu M, Ongel K et al (2009) Antioxidant enzymes and melatonin levels in patients with bronchial asthma and chronic obstructive pulmonary disease during stable and exacerbation periods. Cell Biochem Funct 27:276–283

    Article  PubMed  CAS  Google Scholar 

  18. Sirmali M, Uz E, Sirmali R et al (2007) Protective effects of erdosteine and vitamins C and E combination on ischemia–reperfusion-induced lung oxidative stress and plasma copper and zinc levels in a rat hind limb model. Biol Trace Elem Res 118:43–52

    Article  PubMed  CAS  Google Scholar 

  19. Abboud RT, Vimalanathan S (2008) Pathogenesis of COPD. Part I: the role of protease-antiprotease imbalance in emphysema. Review. Int J Tuberc Lung Dis 12:361–367

    PubMed  CAS  Google Scholar 

  20. Cay M, Nazıroğlu M, Köylü H (2009) Selenium and vitamin E modulates cigarette smoke exposure-induced oxidative stress in blood of rats. Biol Trace Elem Res 131:62–70

    Article  PubMed  CAS  Google Scholar 

  21. Kamanlı A, Nazıroğlu M, Aydilek N et al (2004) Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis. Cell Biochem Funct 22:53–57

    Article  PubMed  Google Scholar 

  22. Karadag F, Cildag O, Altınısık M et al (2004) Trace elements as a component of oxidative stress in COPD. Respirology 9:33–37

    Article  PubMed  Google Scholar 

  23. El-Attar M, Said M, El-Assal G et al (2009) Serum trace element levels in COPD patient: the relation between trace element supplementation and period of mechanical ventilation in a randomized controlled trial. Respirology 14(8):1180–1187

    Article  PubMed  Google Scholar 

  24. Dagli CE, Tanrikulu AC, Koksal N et al (2010) Interstitial lung disease in coppersmiths in high serum copper levels. Biol Trace Elem Res 137:63–68

    Article  PubMed  CAS  Google Scholar 

  25. Gray RD, Duncan A, Noble D et al (2010) Sputum trace metals are biomarkers of inflammatory and suppurative lung disease. Chest 137(3):635–641

    Article  PubMed  CAS  Google Scholar 

  26. Onal S, Nazıroğlu M, Colak M et al (2010) Effects of different medical treatments on serum copper, selenium and zinc levels in patients with rheumatoid arthritis. Biol Trace Elem Res. doi:10.1007/s12011-010-8826-7

  27. Folkers K (1974) The potential of coenzyme Q10 (NSC-140865) in cancer treatment. Cancer Chem Rep 4:19–22

    CAS  Google Scholar 

  28. Folkers K, Osterborg A, Nylander M et al (1997) Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. Biochem Biophys Res Commun 234:296–299

    Article  PubMed  CAS  Google Scholar 

  29. Lockwood K, Moesgaard S, Yamamoto T et al (1995) Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun 212:172–177

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chest Disease, Medical Faculty, Dicle University, Diyarbakir, Turkey

    Abdullah Cetin Tanrikulu & Abdurrahman Abakay

  2. Department Biochemistry, Medical Faculty, Dicle University, Diyarbakir, Turkey

    Osman Evliyaoglu

  3. Department of Public Health, Medical Faculty, Dicle University, Diyarbakir, Turkey

    Yilmaz Palanci

  4. Department of Chest Diseases, School of Medicine, Dicle University, 21180, Diyarbakir, Turkey

    Abdullah Cetin Tanrikulu

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  1. Abdullah Cetin Tanrikulu
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  2. Abdurrahman Abakay
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  3. Osman Evliyaoglu
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  4. Yilmaz Palanci
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Correspondence to Abdullah Cetin Tanrikulu.

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Tanrikulu, A.C., Abakay, A., Evliyaoglu, O. et al. Coenzyme Q10, Copper, Zinc, and Lipid Peroxidation Levels in Serum of Patients with Chronic Obstructive Pulmonary Disease. Biol Trace Elem Res 143, 659–667 (2011). https://doi.org/10.1007/s12011-010-8897-5

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  • DOI: https://doi.org/10.1007/s12011-010-8897-5

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