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Medically serious adverse effects of newer antidepressants

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Abstract

Although safer than tricyclic antidepressants and monoamine oxidase inhibitors, the newer antidepressants may be associated with certain medically serious adverse effects, of which cardiovascular adverse effects, seizures, abnormal bleeding, hyponatremia, and agranulocytosis are discussed in this review. Data regarding the incidence and risk factors are summarized, and strategies for reducing the risk of these adverse effects and managing them are suggested. Identification of risk factors, appropriate antidepressant choice, and, when possible, careful monitoring may substantially reduce the incidence of these adverse effects and the morbidity associated with them.

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  1. Mood Disorders Program, Thomas Jefferson University, 833 South Chestnut Street, Suite 210E, Philadelphia, PA, 19107, USA

    Rajnish Mago

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  1. Rajnish Mago
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  2. Rajeev Mahajan
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  3. Michael E. Thase
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Correspondence to Rajnish Mago.

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Mago, R., Mahajan, R. & Thase, M.E. Medically serious adverse effects of newer antidepressants. Curr Psychiatry Rep 10, 249–257 (2008). https://doi.org/10.1007/s11920-008-0041-2

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