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Gender Differences in Epidemiology, Pathophysiology, and Treatment of Hypertension

  • Women and Ischemic Heart Disease (A. Maran, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review aims to examine gender differences in both the epidemiology and pathophysiology of hypertension and to explore gender peculiarities on the effects of antihypertensive agents in decreasing BP and CV events.

Recent Findings

Men and women differ in prevalence, awareness, and control rate of hypertension in an age-dependent manner. Studies suggest that sex hormones changes play a pivotal role in the pathophysiology of hypertension in postmenopausal women. Estrogens influence the vascular system inducing vasodilatation, inhibiting vascular remodeling processes, and modulating the renin-angiotensin aldosterone system and the sympathetic system. This leads to a protective effect on arterial stiffness during reproductive age that is dramatically reversed after menopause.

Summary

Data on the efficacy of antihypertensive therapy between genders are conflicting, and the underrepresentation of aged women in large clinical trials could influence the results. Therefore, further clinical research is needed to uncover potential gender differences in hypertension to promote the development of a gender-oriented approach to antihypertensive treatment.

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Authors and Affiliations

  1. Department of Life, Health & Environmental Sciences, University of L’Aquila, L’Aquila, Italy

    Paolo Di Giosia, Paolo Giorgini, Cosimo Andrea Stamerra, Marco Petrarca & Claudio Ferri

  2. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran

    Amirhossein Sahebkar

  3. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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  1. Paolo Di Giosia
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Correspondence to Amirhossein Sahebkar.

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Paolo Di Giosia, Paolo Giorgini, Cosimo Andrea Stamerra, Marco Petrarca, Claudio Ferri, and Amirhossein Sahebkar declare no conflict of interest.

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Di Giosia, P., Giorgini, P., Stamerra, C.A. et al. Gender Differences in Epidemiology, Pathophysiology, and Treatment of Hypertension. Curr Atheroscler Rep 20, 13 (2018). https://doi.org/10.1007/s11883-018-0716-z

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