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Guanxin II (冠心II号) for the management of coronary heart disease

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Abstract

This article presents an integrated overview of Guanxin II (冠心II号) regarding its quality control, pharmacokinetics, pharmacology, clinical studies, adverse events, dosage and administration, and its pharmacoeconomic assessment. It has been demonstrated that Guanxin II has beneficial effects on coronary heart disease (CHD). The underlying mechanism was proved to be its anti-ischemic, anti-apoptotic, antioxidative, antiplatelet and anti-inflammatory effects, and so on. Tanshinol, hydroxysafflor yellow A and ferulic acid might be responsible for the cardioprotective effect of Guanxin II. In terms of acquisition cost, Guanxin II is cheaper than other drugs currently available for CHD. Guanxin II is safe, cheap, and effective in the management of CHD. However, the mechanism of its cardioprotective effects has not been completely understood because of limitations in the research methodologies of Chinese medicine. Further work should be carried out with single components such as tanshinol, hydroxysafflor yellow A and ferulic acid, using modern biochemical and molecular methods.

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References

  1. Cheng JW. Ranolazine for the management of coronary artery disease. Clin Ther 2006;28:1996–2007.

    Article  PubMed  CAS  Google Scholar 

  2. Nabel EG. Cardiovascular disease. N Engl J Med 2003;349:60–72.

    Article  PubMed  CAS  Google Scholar 

  3. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, et al. Heart disease and stroke statistics—2006 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006;113:85–1

    Article  Google Scholar 

  4. Abrams J. Clinical practice. Chronic stable angina. N Engl J Med 2005;352:2524–2533.

    Article  PubMed  CAS  Google Scholar 

  5. Chen KJ, Qian ZZ, Liu WL. Observation on long-term effects of Guanxin II in treating 164 patients with angina pectoris of coronary heart disease. J Cardiovasc Dis (Chin) 1978;6:22–24.

    Google Scholar 

  6. Zhao J, Huang X, Tang W, Ren P, Xing Z, Tian X, et al. Effect of oriental herbal prescription Guan-Xin-Er-Hao on coronary flow in healthy volunteers and anti-apoptosis on myocardial ischemiareperfusion in rat models. Phytother Res 2007;21:926–931.

    Article  PubMed  Google Scholar 

  7. Makino T, Wakushima H, Okamoto T, Okukubo Y, Deguchi Y, Kano Y. Pharmacokinetic interactions between warfarin and kangen-karyu, a Chinese traditional herbal medicine, and their synergistic action. J Ethnopharmacol 2002;82:35–40.

    Article  PubMed  CAS  Google Scholar 

  8. The Pharmacopoeia of the People’s Republic of China. 2005 ed. Vol. 1. Beijng: Chemical Industry Press; 2005:653–654.

  9. Huang J, Tian J, Zhu W. Content determination of danshensu and protocatechuic aidehyde contents of Salvia Milfiorrhiza and Coronary Heart No II Decoction in different decocting methods by HPLC respectively. Chin J Inf Tradit Chin Med (Chin) 2005;12:44–46.

    Google Scholar 

  10. Gan HQ, Huang X, Qu Y, Ren P, Zhang S, Mei Q. Simultaneous determination of danshensu, protocatechuic aldehyde, paeoniflorin and ferulic acid in Guan-Xin-II Decoction by RP-HPLC. J Fourth Milit Med Univ (Chin) 2004;25:772–775.

    CAS  Google Scholar 

  11. Gan HQ, Mei QB, Qu Y, Huang X. Quality study on Guanxin II Decoction. Chin Pharm (Chin) 2005;16:1695–1696.

    Google Scholar 

  12. Wang LL, Huang X, Ren P, Zhang L, Zhang HX. Determination of contents of paeoniflorin and ferulic acid in No. 2 Decoction of coronary heart by reversed phase supercritical fluid extraction and chromatography. J Chengdu Univ Tradit Chin Med (Chin) 2001;24:51–52.

    Google Scholar 

  13. Wang J, Feng W, Tong Y, Yan J, Wang Z, Zhu X, et al. Comparative studies on the purifying conditions of the elixation of the Guanxin II Decoction. Chin J Exp Tradit Med Form (Chin) 2007;13:14–16.

    Google Scholar 

  14. Tong Y, Wang J, Feng W, Yan J, Wang Z, Zhu X, et al. Effect of the two kinds of decocting methods on contents of main active components in Guanxin II Decoctions. Chin J Exp Tradit Med Form (Chin) 2007;13:24–26.

    CAS  Google Scholar 

  15. Qiao X, Han J, Xu M, Zhang ZC, Sun SF, Li HF, et al. Characterization of chemical constituents in Guan Xin II Decoction by liquid chromatography coupled with electrospray ionization-mass spectrometry. Planta Med 2008;74:1720–1729.

    Article  PubMed  CAS  Google Scholar 

  16. Qiao X, Xu M, Han J, Guo DA. Progresses: constituents and pharmacological analyses of Guan Xin Er Hao Decoction. World Sci Tech-Mod Tradit Chin Med (Chin) 2007;9:86–95.

    Google Scholar 

  17. Qin F, Huang X, Zhang HM, Ren P. Pharmacokinetic comparison of puerarin after oral administration of Jiawei-Xiaoyao-San in healthy volunteers and functional dyspepsia patients: influence of disease state. J Pharm Pharmacol 2009;61:125–129.

    Article  PubMed  CAS  Google Scholar 

  18. Gan HQ, Mei QB, Wang Y, Huang X. Serum pharmacochemistry changes of Guanxin II Oral Decoction in healthy volunteers. Chin Pharm (Chin) 2006;17:173–177.

    CAS  Google Scholar 

  19. Ye G, Li YZ, Li YY, Guo HZ, Guo DA. SPE-HPLC method for the determination and pharmacokinetic studies on paeoniflorin in rat serum after oral administration of traditional Chinese medicinal preparation Guan-Xin-Er-Hao Decoction. J Pharm Biomed Anal 2003;33:521–527.

    Article  PubMed  CAS  Google Scholar 

  20. Hu Y, Chen W, Zhang Y, Li L, Zhang GM, Yang W, et al. Degradation of paeoniflorin in Guanxin II prescription by intestinal bacteria. Chin Pharm J (Chin) 2007;42:1813–1818.

    CAS  Google Scholar 

  21. Yang XG, Peng B, Zhang GH, Wei LL, Nie SF, Pan WS. Studies of the pharmacokinetics of paeoniflorin in two Jing-Zhi-Guan-Xin formulations after oral administration to beagle dogs. J Pharm Biomed Anal 2006;41:320–324.

    Article  PubMed  CAS  Google Scholar 

  22. Gan HQ, Mei QB, Zhu W, Huang X. Pharmacokinetics of ferulic acid in serum of healthy male volunteers after oral administration of Guanxin II Decoction. Chin Pharm (Chin) 2007;18:109–111.

    Google Scholar 

  23. Ren P, Huang X, Chen K, Zhang L, Wang LL, Ma XC. Comparison of ferulic acid concentration-time profiles absorbed into serum between oral ligusticum wallichi and Guanxin II Decoctions. Chin Heart J (Chin) 2000;12:253–254.

    Google Scholar 

  24. Huang X, Qin F, Zhang HM, Xiao HB, Wang LX, Zhang XY. Cardioprotection by Guanxin II in rats with acute myocardial infarction is related to its three compounds. J Ethnopharmacol 2009;121:268–273.

    Article  PubMed  CAS  Google Scholar 

  25. Zeng X, He H, Yang J, Yang X, Wu L, Yu J. Temporal effect of Guanxin No. 2 on cardiac function, blood viscosity and angiogenesis in rats after long-term occlusion of the left anterior descending coronary artery. J Ethnopharmacol 2008;118:485–494.

    Article  PubMed  CAS  Google Scholar 

  26. Gan HQ, Huang X, Tian XQ, Zhu YS, Zhang SH, Li J, et al. Effect of oral administration of Guanxin II Decoction on coronary blood flow and cardiac systolic/diastolic function in healthy males. Chin J Integr Tradit West Med (Chin) 2004;24:785–789.

    Google Scholar 

  27. Tian X, Qian Y, Huang X, Zhu Y, Gan H, Li J, et al. Evaluating effects of Guan-Xin-Er-Hao Decoction on coronary artery hemodynamics in healthy men using coronary artery flow imaging. Chin J Ultrasound Med (Chin) 2004;20:936–939.

    Google Scholar 

  28. Tang W, Chen D, Huang X, Ren P, Xia Q, Wan M, et al. Effect of Coronary Heart No. 2 on the hemodynamics of inferior mesentery artery in healthy male volunteers. Chin J Exp Tradit Med Form (Chin) 2006;12:70–72.

    Google Scholar 

  29. Xu LN, Yin ZZ, Ou YR. The effect of compositus Guan-Xin No. 2 on myocardial ischemia and hypoxia in experimental animals. Atca Pharm Sin (Chin) 1979;14:461–466.

    CAS  Google Scholar 

  30. Zhao HW, Qin F, Liu YX, Huang X, Ren P. Antiapoptotic mechanisms of Chinese medicine formula, Guan-Xin-Er-Hao, in the rat ischemic heart. Tohoku J Exp Med 2008;216:309–316.

    Article  PubMed  Google Scholar 

  31. Wei H, Yang L, Li Q, Li L. Efects of Guanxin II formula on myocardial apoptosis of acute myocardial ischemia in rats. Pharmacol Clin Chin Mater Med (Chin) 2008;24:1–4.

    Google Scholar 

  32. Qin F, Liu YX, Zhao HW, Huang X, Ren P, Zhu ZY. Chinese medicinal formula Guan-Xin-Er-Hao protects the heart against oxidative stress induced by acute ischemic myocardial injury in rats. Phytomedicine 2009;16:215–221.

    Article  PubMed  CAS  Google Scholar 

  33. Wei H, Yang L, Li L. Effect of Guanxin II on myocardial pathological injury and myocardial enzymes in acute myocardial infarction rats. Lishizhen Med Mater Med Res (Chin) 2008;19:1552–1553.

    Google Scholar 

  34. Wang ZY, Qian RQ, Guan SH, Feng XZ, Guo DA, Yan JJ, et al. Study on free radical mechanism of Guanxin II in antagonizing ischemic myocardial damage. Chin J Integr Tradit West Med (Chin) 2003;23:363–366.

    Google Scholar 

  35. Su Y, Li Y, Li P, Li L. Effects of blood serum of different officinal forms of Guanxin II formula on ischemiareperfusion injury in cultured rat myocardial cells. Pharmacol Clin Chin Mater Med (Chin) 2007;23(3):1–4.

    CAS  Google Scholar 

  36. Gao H, Li Y, Li L. Comparative study on the protective effects of different Guanxin II formula on acute myocardial ischemia in dogs. Pharmacol Clin Chin Mater Med (Chin) 2007;23(5):1–4.

    Google Scholar 

  37. Zhang WX, Bai Y, Yue FZ. Influence of Guanxin II on plasma lysophosphatidic acid level in patients with unstable angina. Shaanxi J Tradit Chin Med (Chin) 2006;27:150–151.

    Google Scholar 

  38. Wang Y, Liu J, Weng Z. Effect of Guanxin No. 2 combination herb on hemorheology. Prac Clin J Integr Tradit Chin West Med (Chin) 1997;10:1427–1430.

    Google Scholar 

  39. Zhang M, Wen JK, Chen X, Xu Z. Experimental study on effects of Guanxin II on plasma lipid, TNF-α, NO and TXA2/ PGI2 in rats. Chin J Tradit Med Sci Technol 2008;15:20–21.

    Google Scholar 

  40. Zeng X, Yang J, Yang X, Hong D, Wu L, Yu J. Effect of Guanxin No. 2 Decoction on gene expression in different areas of the myocardial infarcted heart of rats using microarray technology. J Pharm Pharmacol 2009;61:213–219.

    Article  PubMed  CAS  Google Scholar 

  41. Yu CY, Liu Z, Xu XM, Li YK, Li LD. Effects of Guanxin II on crdiac protein expression after acute myocardial ischemia on rats. China J Chin Mater Med (Chin) 2008;33:1605–1609.

    Google Scholar 

  42. Yu CY, Gao HL, Liu Z, Xu XM, Li YQ, Li LD. Effect of Guanxin No. 2 on gene variant expression profile in rats after myocardial ischemia. Chin J Integr Tradit West Med (Chin) 2008;28:426–430.

    CAS  Google Scholar 

  43. Tune JD, Gorman MW, Feigl EO. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 2004;97:404–415.

    Article  PubMed  Google Scholar 

  44. Razavi HM, Hamilton JA, Feng Q. Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure. Pharmacol Ther 2005;106:147–162.

    Article  PubMed  CAS  Google Scholar 

  45. Kehrer JP. Cause-effect of oxidative stress and apoptosis. Teratology 2000;62:235–236.

    Article  PubMed  CAS  Google Scholar 

  46. Wattanapitayakul SK, Bauer JA. Oxidative pathways in cardiovascular disease: roles, mechanisms, and therapeutic implications. Pharmacol Ther 2001;89:187–206.

    Article  PubMed  CAS  Google Scholar 

  47. Angiolillo DJ, Guzman LA, Bass TA. Current antiplatelet therapies: benefits and limitations. Am Heart J 2008;156:S3–S9

    Article  PubMed  CAS  Google Scholar 

  48. Haensel A, Mills PJ, Nelesen RA. The relationship between heart rate variability and inflammatory markers in cardiovascular diseases. Psychoneuroendocrinology 2008;33:1305–1312.

    Article  PubMed  CAS  Google Scholar 

  49. Li LD, Liu JX. The pharmacology studies of Jingzhi-Guanxin. J Trad Chin Med (Chin) 1994;5:32.

    Google Scholar 

  50. Chen KJ, Tao SQ, Chen ZJ. The double-blind trial of Jingzhi-Guanxin granula for angina pectoris 112 cases. Chin J Cardiol (Chin) 1982;10:85.

    CAS  Google Scholar 

  51. Qu SJ. Therapeutic effect of purified Guanxin Soft Capsule in the treatment of angina of coronary heart disease. J Pract Med Tech (Chin) 2007;14:1425–1426.

    Google Scholar 

  52. Xu R, Huang X, Li Y, Zhang L, Wang L, Cui P. Clinical observation of treating coronary heart disease with Guanxinerhao. J Chengdu Univ Tradit Chin Med (Chin) 2001;24:17–19.

    CAS  Google Scholar 

  53. Zhu AM, Huo P. Treating 42 cases of senile coronary heart disease with Guanxin-II prescription. Hunan Guid J Tradit Chin Med Pharmacol (Chin) 2002;8:63.

    Google Scholar 

  54. Wang HJ. Clinical obseveration of Guanxin II for angina pectoris in 122 cases. J Pract Med Tech (Chin) 2006;13:3428–3429.

    Google Scholar 

  55. Chen KJ, Qian ZZ, Weng WL. Clinical observation of treating coronary heart disease 100 cases with Huoxue-Chongji. In: Chen KJ, ed. The research of blood stasis syndrome and activating blood to remove blood stasis. Beijing: Peking Medical College & Peking Union Medical College Press;1993:290.

    Google Scholar 

  56. Zhao HL, Liu JL. Clinical observation of treating coronary heart disease with Jiawei Guanxin 2 in 160 cases. J Sichuan Tradit Chin Med (Chin) 2006;24:60.

    Google Scholar 

  57. Peng B, Zhao Z. Guanxin II curing coronary heart disease angina pectoris 60 case clinic study. Chin J Pract Chin Modern Med (Chin) 2005;18:948–949.

    Google Scholar 

  58. Yang HW, Yang ZQ, Zhao LC. Angina pectoris of coronary heart disease treated by Shengmai-san and Guanxin II in 109 cases. Guangming J Tradit Chin Med (Chin) 2005;20:60–61.

    CAS  Google Scholar 

  59. Drugs price of Sichuan province. Sichuan Province Medicine Company;2007:23.

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Authors and Affiliations

  1. Department of Integrated Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China

    Feng Qin  (秦 锋) & Xi Huang  (黄 熙)

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  1. Feng Qin  (秦 锋)
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  2. Xi Huang  (黄 熙)
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Correspondence to Xi Huang  (黄 熙).

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Supported by National Natural Science Foundation of China (No. 30572339 and No. 30325045)

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Qin, F., Huang, X. Guanxin II (冠心II号) for the management of coronary heart disease. Chin. J. Integr. Med. 15, 472–476 (2009). https://doi.org/10.1007/s11655-009-0472-6

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  • DOI: https://doi.org/10.1007/s11655-009-0472-6

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