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Expression of pigment epithelium-derived factor in bladder tumour is correlated with interleukin-8 yet not with interleukin-1α

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Summary

Pigment epithelium-derived factor (PEDF) is an antiangiogenic factor which is effective in tumour inhibition in a variety of tumours and has not yet been studied in bladder tumour before. In this study the expression of PEDF, interleukin-1α (IL-1α) and -8 (IL-8) in bladder tumours was investigated. Immunohistochemistry was performed on 64 bladder tumour and 23 normal uroepithelium samples. Expression change of the factors was compared with clinicopathological parameters. Correlations between PEDF, IL-1α and IL-8 were analyzed. None of the factors was in relation to gender, tumour occurrence, and size or onset pattern. PEDF (P=0.014) and IL-1α (P=0.049) expression was down-regulated with grade progression. PEDF expression was lower in normal uroepithelium than in papillary urothelial neoplasm of low malignant potential (PUNLMP) (P=0.000) and carcinoma (P=0.009) whilst IL-1α (P=0.000 and P=0.000 respectively) and IL-8 (P=0.000 and P=0.023 respectively) expression was higher in the same grouping. PEDF expression had a negative correlation with IL-8 in PUNLMP (P=0.049, r=−0.578) as well as in tumour grouping (P=0.033, r=−0.276). Deranged expressional change of PEDF, IL-1α and IL-8 could be in relation to loss of differentiation from normal uroepithelium to papillary lesion and eventually to carcinoma.

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Authors and Affiliations

  1. Department of Urology, Fudan University, Shanghai, 200040, China

    Chenchen Feng  (冯陈陈), Qiang Ding  (丁 强), Haowen Jiang  (姜昊文), Hui Wen  (温 晖) & Zhong Wu  (吴 忠)

  2. Centre of Laboratory Medicine, Fudan University, Shanghai, 200040, China

    Ming Guan  (关 明)

  3. Institute of Urology, Fudan University, Shanghai, 200040, China

    Yuanfang Zhang  (张元芳)

  4. Department of Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China

    Paohsun Wang  (王保勋)

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  1. Chenchen Feng  (冯陈陈)
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  2. Ming Guan  (关 明)
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  3. Qiang Ding  (丁 强)
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  8. Zhong Wu  (吴 忠)
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Corresponding author

Correspondence to Zhong Wu  (吴 忠).

Additional information

Both authors contributed equally to this work.

This project was sponsored in part by Science and Technology Commission of Shanghai Municipality, China (No. 07ZR14018).

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Feng, C., Guan, M., Ding, Q. et al. Expression of pigment epithelium-derived factor in bladder tumour is correlated with interleukin-8 yet not with interleukin-1α. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 21–25 (2011). https://doi.org/10.1007/s11596-011-0144-6

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  • DOI: https://doi.org/10.1007/s11596-011-0144-6

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