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Critical analysis of radioiodination techniques for micro and macro organic molecules

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Abstract

A variety of radioiodination methods is available in the literature depending upon the nature of organic compound to be labeled, however only few can completely fulfill manufacturing requirements.Ideally a selected method should be one which offers maximum benefits like regioselectivity, minimum reaction steps, minimum reaction time, high radiochemical yield and high specific activity. In this review radioiodination techniques were critically analyzed. Advantages, drawbacks, possible mode of action and special reaction conditions required to get high radiochemical yield were taken into account. The influence of iodine introduction on physicochemical properties, in vivo or in vitro pharmacological properties of pharmaceutical due to increase of lipophilicity were discussed along with examples.

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Acknowledgments

This work was supported by the National Research Foundation of Korea grant funded by the Korean Government (Grant Nos. 2012M2B2B1055245 and 2012M2A2A6011335) and Korean Atomic Energy Research Institute. Authors also highly acknowledge Higher Education Commission of Pakistan for the award of PhD Fellowship under “PhD Fellowship for 5000 Scholars” (Indigenous) Scheme, Batch-VI, 2010 (17-5-6(Ps6-135)/HEC/Sch/2010).

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  1. Division of Biotechnology, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk, 580-185, Republic of Korea

    Sajid Mushtaq, Jongho Jeon, Beom Su Jang & Sang Hyun Park

  2. Department of Radiation Biotechnology and Applied Radioisotope Science, Korea University of Science and Technology, Daejeon, 305-350, Republic of Korea

    Sajid Mushtaq, Jongho Jeon, Beom Su Jang & Sang Hyun Park

  3. Department of Chemistry, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan

    Aqeela Shaheen

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Mushtaq, S., Jeon, J., Shaheen, A. et al. Critical analysis of radioiodination techniques for micro and macro organic molecules. J Radioanal Nucl Chem 309, 859–889 (2016). https://doi.org/10.1007/s10967-015-4679-z

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