Abstract
A hydrogel intervertebral disc (IVD) model consisting of an inner nucleus core and an outer anulus ring was manufactured from 30 and 35% by weight Poly(vinyl alcohol) hydrogel (PVA-H) concentrations and subjected to axial compression in between saturated porous endplates at 200 N for 11 h, 30 min. Repeat experiments (n = 4) on different samples (N = 2) show good reproducibility of fluid loss and axial deformation. An axisymmetric nonlinear poroelastic finite element model with variable permeability was developed using commercial finite element software to compare axial deformation and predicted fluid loss with experimental data. The FE predictions indicate differential fluid loss similar to that of biological IVDs, with the nucleus losing more water than the anulus, and there is overall good agreement between experimental and finite element predicted fluid loss. The stress distribution pattern indicates important similarities with the biological IVD that includes stress transference from the nucleus to the anulus upon sustained loading and renders it suitable as a model that can be used in future studies to better understand the role of fluid and stress in biological IVDs.
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References
D. S. McNALLY and R. G. C. ARRIDGE, J. Biomech. 28 (1995) 53.
N. BOGDUK, “Clinical anatomy of the Lumbar Spine and Sacrum” (United Kingdom, Churchill Livingstone, 1997).
E. J. CHIU, in Proceedings of the 43rd Annual Meeting, Orthopaedic Research Society (San Fransisco, CA, 1997).
A. E. BAER, M. W. GRINSTAFF, K. A. SMEDS, L. M. BOYD and L. A. SETTON, in Proceedings of the Bioengineering Conference, ASME, 2001.
A. S. HOFFMAN, Adv. Drug Delivery Rev. 43 (2002).
A. S. HOFFMAN, Ann NY Acad Sci. 944 (2001) 62.
O. WICHTERLE and D. LIM, Nature 185 (1960) 117.
D. DARWIS, P. STASICA, M. T. RAZZAK and J. M. ROSIAK, Rad. Phys. Chem. 63 (2002) 539.
L. AMBROSIO, P. A. NETTI, S. IANNACE, J. HUANG and L. NICOLAIS, J. Mater. Sci.: Mater Med. 7 (1996) 251.
Q. B. BAO and P. A. HIGHAM, US Patent 5,192,326 (1993).
M. CIACH and J. AWREJCEWICZ, in Proceedings of the European Medical and Biological Engineering Conference, Vienna, 1999.
N. D. BROOM and A. OLOYEDE, Biomaterials 19 (1998) 1179.
A. A. J. GOLDSMITH, A. HAYES and S. E. CLIFT, ABAQUS Users’ Conference, Paris, France, 1995, p. 305.
E. WOLFGANG, A. AYHAN and M. BERND, Proc. Appl. Math. Mech. 2 (2003).
F. YOSHII, K. MAKUUCHI and D. DARWIS, et al., Rad. Phys. Chem. 46 (1995) 169.
M. KOBAYASHI, J. TOGUCHIDA and M. OKA, Biomaterials 24 (2003) 639.
J. A. STAMMEN, S. WILLIAMS, D. N. KU and R. E. GULDBERG, ibid. 22 (2001) 799.
S.-H. HYON and Y. IKADA, US patent No, 4,663,358 (1986).
P. SILVA, S. C. DREW, S. CROZIER, M. VEIDT and M. J PEARCY, in Proceedings of the World Congress on Medical Physics and Biomedical Engineering, Sydney [CD-ROM] ISBN 1877040142 paper no. 3677, 2003, p. 4.
HIBBIT, KARLSSON and SORENSEN, ABAQUS Theory and User’s Manual, version 6.3 (2002).
M. A. BIOT, J. Appl. Phys. 12 (1941) 155.
W. G. SCHERER and R. M. SWIATEK, J. Non-Cryst. Solids 113 (1989) 119.
M. ARGOUBI and A. SHIRAZI-ADL, J. Biomech. 29 (1996) 1331.
N. D. BROOM and R. FLACHMANN, J. Anatomy 202 (2003) 495.
D. S. MCNALLY and M. A. ADAMS, Spine 17 (1992) 66.
J. CASSIDY, A. HILTNER and E. BAER, J. Mater. Sci.: Mater. Med. 1 (1990) 69.
A. L. NACHEMSON, Acta Orthop. Scand. S43 (1960) 12.
W. Y. GU, X. G. MAO and R. J. FOSTER, et al., Spine 24 (1999) 2449.
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Silva, P., Crozier, S., Veidt, M. et al. An experimental and finite element poroelastic creep response analysis of an intervertebral hydrogel disc model in axial compression. J Mater Sci: Mater Med 16, 663–669 (2005). https://doi.org/10.1007/s10856-005-2538-0
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DOI: https://doi.org/10.1007/s10856-005-2538-0