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ACE2 and FZD1 are prognosis markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of gallbladder

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Abstract

The clinicopathological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) of the gallbladder have not been well documented, and no prognosis marker has been identified because of the rare occurrence of this gallbladder cancer subtype. In this study, we examined ACE2 and FZD1 expression in 46 SC/ASCs and 80 adenocarcinomas using immunohistochemistry and further analyzed their correlations with clinicopathological characteristics. We demonstrated that positive FZD1 and negative ACE2 expression were significantly associated with large tumor size, high TNM stage, lymph node metastasis and invasion of SC/ASC and AC. Univariate Kaplan–Meier analysis showed that positive FZD1 and negative ACE2 expression as well as differentiation, tumor size, TNM stage, lymph node metastasis, invasion, and surgical curability were closely associated with decreased overall survival in both SC/ASC (p < 0.001) and AC (p < 0.001) patients. The average survival time in SC/ASC and AC patients with FZD1−ACE2+ expression was significantly longer than that in patients with FZD1+ACE2− or FZD1+ACE2+ (p < 0.01). Multivariate Cox regression analysis showed that positive FZD1 and negative ACE2 expression are independent poor-prognostic factors for both SC/ASC and AC patients. In addition, FZD1 expression positively, but ACE2 expression negatively correlated with the expression of CA19-9 in SC/ASC and AC. Our study suggested that positive FZD1 and negative ACE2 expression are closely related to the expression of CA19-9; clinical, pathological, and biological behaviors; as well as poor-prognosis of gallbladder cancer.

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The authors declared no conflicts of interest.

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Authors and Affiliations

  1. Department of Pathology, Basic School of Medicine, Central South University, Changsha, 410078, Hunan, People’s Republic of China

    Jinghe Li

  2. Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People’s Republic of China

    Zhu-lin Yang & Xuebao Ren

  3. Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, People’s Republic of China

    Qiong Zou & Yuan Yuan

  4. Department of Hepatobiliary and Pancreatic Surgery, Hunan Provincial People’s Hospital, Changsha, 410007, Hunan, People’s Republic of China

    Lufeng Liang

  5. Department of Pathology, Loudi Central Hospital, Loudi, 417011, Hunan, People’s Republic of China

    Meigui Chen

  6. Department of Pathology, Hunan Provincial Tumor Hospital, Changsha, 410013, Hunan, People’s Republic of China

    Senlin Chen

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  1. Jinghe Li
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  2. Zhu-lin Yang
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  3. Xuebao Ren
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  4. Qiong Zou
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  5. Yuan Yuan
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  7. Meigui Chen
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Correspondence to Zhu-lin Yang.

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Li, J., Yang, Zl., Ren, X. et al. ACE2 and FZD1 are prognosis markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of gallbladder. J Mol Hist 45, 47–57 (2014). https://doi.org/10.1007/s10735-013-9528-1

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  • DOI: https://doi.org/10.1007/s10735-013-9528-1

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