Abstract
This study examines antidepressant response in 52 adolescents after 6 months of treatment in a community mental health clinic. No patients were excluded based on psychiatric or medical co-morbidity. Symptomatic and functional outcome measures were administered to patients and parents. A pharmacotherapy algorithm was followed. Thirty-four patients (65%) completed the 6 month of treatment. Eighty-eight percent of patients improved, while 47% responded. These results are compared to response rates in acute research studies, in continuation studies, and in a study of depressed adults treated in a community clinic. Conclusions: research to improve response rates to antidepressants in the real world is urgently needed, since it appears that rates are low and diminish with age.
Similar content being viewed by others
References
L. Bastiaens (2004) ArticleTitleResponse to antidepressant treatment in a community mental health center Community Mental Health Journal 40 561–567 Occurrence Handle15672694
L. Bastiaens (1998) ArticleTitlePediatric psychopharmacology in a capitated managed care system: How do patients fare? Journal of Child and Adolescent Psychopharmacology 2 115–124 Occurrence Handle10.1089/cap.1998.8.115
A. T. Beck D. Guth R. A. Steer R. Ball (1997) ArticleTitleScreening for major depressive disorders in medical inpatients with the Beck Depression Inventory for Primary Care Behavior Research and Therapy 35 785–791 Occurrence Handle1:STN:280:ByiH3c%2FmtlI%3D
J. Q. Bostic J. Prince K. Brown S. Place (2001) ArticleTitleA retrospective study of Citalopram in adolescents with depression Journal of Child and Adolescent Psychopharmacology 11 159–166 Occurrence Handle11436955 Occurrence Handle1:STN:280:DC%2BD38%2FhvVCgsA%3D%3D
G. J. Elmslie J. H. Heiligenstein K. D. Wagner (2002) ArticleTitleFluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trial Journal of American Academy of Child and Adolescent Psychiatry 41 1205–1215
G. J. Elmslie A. J. Rush W. A. Weinberg R. A. Kowatch T. Carmody T. L. Mayes (1998) ArticleTitleFluoxetine in child and adolescent depression: acute and maintenance treatment Depression and Anxiety 7 32–39
G. J. Elmslie A. J. Rush W. A. Weinberg (1997) ArticleTitleA double-blind, randomized, placebo-controlled trial of fluoxetine in depressed children and adolescents Archives General Psychiatry 54 1031–1037
K. D. Gadow J. Sprafkin (1997) Adolescent Symptom Inventory-4 Checkmate Plus LTD Stony brook. NY
W. Guy (1976) Early Clinical Drug Evaluation Unit (ECDEU) assessment manual for psychopharmacology NIMH publication Bethesda MD 217–222
M. J. Hilsenroth S. J. Ackerman M. D. Blaggs B. D. Baumann M. R. Baity S. R. Smith J. L. Price C. L. Smith T. L. Heindselman M. K. Mount D. J. Holdwich (2000) ArticleTitleReliability and validity of DSM IV axis V American Journal of Psychiatry 157 IssueID11 1858–1863 Occurrence Handle11058486 Occurrence Handle1:STN:280:DC%2BD3M%2FjsVWgtA%3D%3D
M. B. Keller N. D. Ryan M. Strober (2001) ArticleTitleEfficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial Journal of American Academy of Child and Adolescent Psychiatry 40 762–772 Occurrence Handle1:STN:280:DC%2BD3MzotVehtA%3D%3D
Milin, R. P., Simeon, J., Spenst, W. P. (1999). Double-blind study of paroxetine in adolescents with unipolar major depression. Presented at the 46th annual meeting of the American Academy of Child and Adolescent Psychiatry.
M. K. Nixon R. Milin J. G. Simeon P. Cloutier W. Spenst (2001) ArticleTitleSertraline effects in adolescent major depression and dysthymia: a six month open trial Journal of Child and Adolescent Psychopharmacology 11 131–142 Occurrence Handle11436952 Occurrence Handle1:STN:280:DC%2BD38%2FhvVChuw%3D%3D
R. J. Park I. M. Goodyer (2000) ArticleTitleClinical guidelines for depressive disorders in childhood and adolescence European Child and Adolescent Psychiatry 9 147–161 Occurrence Handle11095037 Occurrence Handle1:STN:280:DC%2BD3MzpsVygtQ%3D%3D
D. S. Pine (2002) ArticleTitleTreating children and adolescents with selective serotonin reuptake inhibitors: how long is appropriate Journal of Child and Adolescent Psychopharmacology 12 189–203 Occurrence Handle12427293
N. Ryan (2003) ArticleTitleMedication treatment for depression in children and adolescents CNS Spectrum 4 283–287
D. V. Sheehan Y. Lecrubier K. Harnett Sheehan J. Janav E. Weiller A. Keskines J. Schinka E. Knapp M. F. Sheehan G. L. Dunbar (1997) ArticleTitleThe validity of the Mini International Neuropsychiatric Interview (MINI) according to the SCID-P and its reliability European Psychiatry 12 232–241
Sheehan, D. V. (1983). Sheehan Disability Scale. In Handbook of Psychiatric Measures (pp. 113–115). Washington DC: APA.
J. G. Simeon V. F. Dinicola H. B. Ferguson (1990) ArticleTitleAdolescent depression: a placebo-controlled fluoxetine treatment study and follow-up Prog Neuropsychopharmacol Biol Psychiatry 14 791–795 Occurrence Handle2293257 Occurrence Handle1:STN:280:By6C2Mnot1I%3D
Wagner, K. D., Wohlberg, C. J. (2002). Efficacy and safety of Sertraline for treatment of pediatric major depressive disorder. Presented at the 155th annual meeting of the American Psychiatric Association.
Wagner, K. D., Robb, A. S., Findling, R., Tiseo, P. J. (2001). Citalopram is effective in the treatment of major depressive disorder in children and adolescents: results of a placebo-controlled trial. Presented at the 44th annual meeting of the American College of Neuropsychopharmacology.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bastiaens, L. Adolescents’ Response to Antidepressant Treatment in a Community Mental Health Center. Community Ment Health J 41, 77–84 (2005). https://doi.org/10.1007/s10597-005-2601-9
Issue Date:
DOI: https://doi.org/10.1007/s10597-005-2601-9