Abstract
Autophagy refers to the process by which lysosomes degrade intracellular components. Three basic forms of it, macro-, micro-, and chaperon-mediated autophagy, exist in cells. Several studies have shown that dysregulation of macroautophagy compromises the viability of neurons. Recent evidence indicates that chaperone-mediated autophagy plays a role in direct degradation of neuronal transcription factor MEF2D, a protein known to promote neuronal survival. Disruption of this regulatory pathway by α-synuclein leads to neuronal stress, which may underlie neuronal loss in Parkinson’s disease.
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Acknowledgments
We thank Brian Ciliax for his critical comments. This work was supported by NIH grants to Z. M. (AG023695, NS048254, ES015317, ES016731-0002) and Robert Woodruff Health Sciences Center Fund.
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Yang, Q., Mao, Z. Dysregulation of autophagy and Parkinson’s disease: the MEF2D link. Apoptosis 15, 1410–1414 (2010). https://doi.org/10.1007/s10495-010-0475-y
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DOI: https://doi.org/10.1007/s10495-010-0475-y