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p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes

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Abstract

HIV-1 Tat is a potent transcriptional activator of the viral promoter with the ability to modulate a number of cellular regulatory circuits including apoptosis. Tat exerts its effects through interaction with viral as well as cellular proteins. Here, we studied the influence of p73, a protein that is implicated in apoptosis and cell cycle control, on Tat apoptotic function in the central nervous system. We recently demonstrated the ability of Tat to associate with p73, and that this association modulates Tat transcriptional activity (Amini et al., Mol Cell Biol 2005; 18: 8126–8138). We demonstrated that p73 interferes with Tat-mediated apoptosis by preventing the up-regulation of Bax and down-regulation of Bcl-2 proteins in astrocytes. Thus, the interplay between Tat and p73 may affect Tat contribution to apoptotic events in the brain, limiting its involvement in the neuropathology often observed in the brains of HIV-1 patients.

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Authors and Affiliations

  1. Department of Neuroscience & Center for Neurovirology, Temple University, 1900 North 12th Street, 015-96, Philadelphia, PA, 19122

    M. Saunders, M. B. Eldeen, L. Del Valle, K. Reiss, F. Peruzzi, G. Mameli, K. Khalili, S. Amini & B. E. Sawaya

  2. Texas Center for NeuroAIDS Research, Department of Pathology, University of Texas Medical Branch at Galveston, Rt. 0785, Galveston, TX, 77555-0785

    B. B. Gelman

  3. Department of Neuroscience & Center for Neurovirology, Temple University, 1900 North 12th Street (015–96), Philadelphia, PA, 19122, USA

    B. E. Sawaya

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  1. M. Saunders
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  2. M. B. Eldeen
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  10. B. E. Sawaya
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Correspondence to B. E. Sawaya.

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Saunders, M., Eldeen, M.B., Valle, L.D. et al. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes. Apoptosis 10, 1419–1431 (2005). https://doi.org/10.1007/s10495-005-2467-x

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  • DOI: https://doi.org/10.1007/s10495-005-2467-x

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