Primary leiomyosarcoma of the femur

doi:10.1007/s007760200045

Journal of Orthopaedic Science

Volume 7, Issue 2, March 2002, Pages 267-273

https://doi.org/10.1007/s007760200045 Get rights and content

Abstract

Leiomyosarcoma usually arises in the uterus,gastrointestinal tract, retroperitoneum, or soft tissue. Primary leiomyosarcoma of bone is rare. We encountered two patients with primary leiomyosarcoma of the femur; one was a 24- year-old woman and the other, a 41-year-old woman. Bone destruction observed on plain radiographs was minimal in both patients. Magnetic resonance imaging (MRI) showed low signal intensity on T1-weighted images and high signal intensity on T2-weighted images, with these areas being much larger than the findings to be expected from the plain radiographs. Histological examination revealed spindle-cell sarcoma, with an interlacing pattern, acidophilic cytoplasm and blunt-ended or “cigar-shaped” nuclei, in both patients. In both patients, immunohistochemical examination showed positive staining for vimentin, desmin, and α-smooth muscle actin. Extensive examination of the gastrointestinal tract and uterus revealed no primary lesion. Therefore, the leiomyosarcoma in the femur was considered to be primary rather than metastatic. Histological examination, including immunohistochemistry,and the exclusion of an extraskeletal primary lesion, is necessary in diagnosing primary leiomyosarcoma of bone.

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Citation Excerpt :
Different age groups may be affected by this tumor, but it generally occurs in older patients [1]. When the tumor originates in extragnathic bones, the most common sites of origin are epiphyseal or metaphyseal locations in the femur or tibia; pelvic origins are rare [3,9,10]. The radius is also an unusual location for this tumor [1].
Primary leiomyosarcoma of bone is a rare aggressive tumor that occurs mainly in older people. It resembles other malignancies clinically and radiologically, and differential diagnosis is based on histopathology, including immunohistochemistry. If leiomyosarcoma is found in bone, the possibility that it is a metastasis from a distant tumor should be investigated. The treatment is surgical excision with wide margins. Here we present three patients who had primary leiomyosarcoma of radius, ilium, and femur, respectively, and who were treated surgically.
Leiomyosarcoma of the humerus: One case of non-specific shoulder pain
2006, Semergen
La gran mayoría de las causas de dolor en partes blandas se deben a patologías benignas, pero a veces pueden deberse a una causa maligna. El leiomiosarcoma primario de hueso es un tumor raro en su frecuencia, que pertenece al grupo de los sarcomas y se debe a la proliferación de células mesenquimales.
El presente caso describe a una mujer de 30 años diagnosticada de leiomiosarcoma primario en el húmero, tras presentar una prolongada clínica de dolor de características osteomusculares en el hombro; esta localización es infrecuente, describiéndose la clínica, las pruebas diagnósticas, anatomopatológicas, el tratamiento y su posterior evolución.
Most of the causes of pain in soft tissues are due to benign diseases but may sometimes be due to a malignant cause. Primary leiomyosarcoma of the bone is a rare tumor in its frequency. It belongs to the sarcoma group and is due to the proliferation of mesenchymal cells.
The present case describes a thirty year old woman diagnosed of primary leiomyosarcoma in the humerus after a long lasting osteomuscular pain in the shoulder. This site is infrequent. The clinical, diagnostic test, and pathological findings, treatment and subsequent outcome are described.
Case report and literature review: Primary leiomyosarcoma of the bone in the trochanteric region of the femur
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Comparison of clinicopathological features and outcomes in patients with primary leiomyosarcoma of bone and soft tissue
2021, Journal of Surgical Oncology
Primary leiomyosarcoma of bone: Clinicopathologic and prognostic factors analysis in a single institution
2019, Acta Ortopedica Brasileira

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Primary leiomyosarcoma of the femur

Abstract

J Am Dent Assoc

Hum Pathol

Primary leiomyosarcoma of bone: a clinicopathologic, immunohistochemical, and ultrastructural study of 33 patients and a literature review

Am J Surg Pathol

Primary leiomyosarcoma of bone

A clinical, radiographic, pathologic-anatomic, and prognostic study of 16 cases. Skeletal Radiol

Sarcoma of the uterus

Obstet Gynecol

Soft tissue tumors

Primary leiomyosarcoma of bone

J Pathol Bacteriol

Leiomyosarcoma in bone: primary or secondary? A case report and review of the literature

Skeletal Radiol

Bone tumors. Diagnosis, treatment, and prognosis

Primary leiomyo-sarcoma of bone. Report of seven cases and review of the literature

Arch Pathol Lab Med