Abstract
The previously published data on the association between CYP1A2*1C (rs2069514) and CYP1A2*1F (rs762551) polymorphisms and cancer risk have remained controversial. Hence, we performed a meta-analysis to investigate the association between CYP1A2*1F and CYP1A2*1C polymorphisms and cancer risk under different inheritance models. Overall, significant association was observed between CYP1A2*1F and cancer risk when all the eligible studies were pooled into the meta-analysis (dominant model: OR 1.08, 95 % CI 1.02–1.15; heterozygous model: OR 1.06, 95 % CI 1.01–1.12; additive model: OR 1.07, 95 % CI 1.02–1.13). In the further stratified and sensitivity analyses, for CYP1A2*1F polymorphism, significantly increased lung cancer risk and significantly decreased bladder cancer risk were observed in Caucasians. For CYP1A2*1C polymorphism, no significant association was found in overall and all subgroup analyses. In summary, this meta-analysis suggests that CYP1A2*1F polymorphism is associated with lung cancer and bladder cancer risk in Caucasians.
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Wen-Xia Zhang and Ying-Hua Chen contributed equally to this study and should be considered as co-first authors. This study was supported by the Natural Science Foundation of Shanxi Province (2013011056-3), The Science and Technology Development Projects of Colleges and Universities of Shanxi Province (20121013), and The Scientific Research Subject of the Health Department of Shanxi Province (201202008).
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Sun, WX., Chen, YH., Liu, ZZ. et al. Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis. Mol Genet Genomics 290, 709–725 (2015). https://doi.org/10.1007/s00438-014-0956-8
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DOI: https://doi.org/10.1007/s00438-014-0956-8