Skip to main content
SpringerLink
Log in

Mixed-type liposarcoma: clinicopathological, immunohistochemical, and molecular analysis of a case arising in deep soft tissues of the lower extremity

  • Case Report
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

A rare case of mixed-type liposarcoma arising in deep soft tissue of the right thigh of a 45-year-old female patient is reported. The neoplasm was completely excised and was composed of an irregular admixture of areas of atypical lipomatous tumor/well-differentiated liposarcoma of the lipoma-like subtype with areas of myxoid/round cell liposarcoma. An amplification of the MDM2 and CDK4 genes respectively in the atypical lipomatous tumor/well-differentiated liposarcoma areas was detected by fluorescence in situ hybridization (FISH) analysis, and translocations of the CHOP and FUS genes were detected by FISH analysis in the myxoid/round cell liposarcoma areas.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. Fletcher CDM, Akerman M, Dal Cin P, de Wever I, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, van den Berghe H, van den Ven W, Vanni R, Willen H (1996) Correlation between clinicopathological features and karyotype in lipomatous tumours. A report of 178 cases from the chromosomes and morphology (CHAMP) collaborative study group. Am J Pathol 148:623–630

    PubMed  CAS  Google Scholar 

  2. Gisselsson D, Höglund M, Mertens F, Johansson B, Dal Cin P, van den Berghe H, Earnshaw WC, Mitelman F, Mandahl F (1999) The structure and dynamics of ring chromosomes in human neoplastic and nonneoplastic cells. Hum Genet 104:315–325

    Article  PubMed  CAS  Google Scholar 

  3. Hashimoto H, Enjoji M (1982) Liposarcoma. A clinicopathologic subtyping of 52 cases. Acta Pathol Jpn 32:933–948

    PubMed  CAS  Google Scholar 

  4. Irie T, Hatori M, Watanabe M, Ehara S, Kokubun S (2003) Radiologically and histologically mixed liposarcoma: a report of two biphasic cases. Jpn J Clin Oncol 33:482–485

    Article  PubMed  Google Scholar 

  5. Kato T, Motohara T, Kaneko Y, Shikishima H, Takahashi T, Okushiba S, Kondo S, Kato H (1999) Case of retroperitoneal dedifferentiated mixed-type liposarcoma: comparison of proliferative activity in specimens from four operations. J Surg Oncol 72:32–36

    Article  PubMed  CAS  Google Scholar 

  6. Kim JI, Choi KU, Lee IS, Moon TY, Lee CH, Kim HW, Kim JY, Park DY, Sol MY (2006) Gene expression in mixed type liposarcoma. Pathology 38:114–119

    Article  PubMed  CAS  Google Scholar 

  7. Kindblom LG, Angervall L, Svendsen P (1975) Liposarcoma. A clinicopathologic, radiographic, and prognostic study. APMIS 253(Suppl.):5–71

    Google Scholar 

  8. Klimstra DS, Moran CA, Perino G, Koss MN, Rosai J (1995) Liposarcoma of the anterior mediastinum and thymus. A clinicopathologic study of 28 cases. Am J Surg Pathol 19:782–791

    Article  PubMed  CAS  Google Scholar 

  9. Meis-Kindblom JM, Sjögren H, Kindblom LG, Peydro-Mellquist A, Röijer E, Aman P, Stenman G (2001) Cytogenetic and molecular genetic analysis of liposarcoma and its soft tissue simulators: recognition of new variants and differential diagnosis. Virchows Arch 439:141–151

    Article  PubMed  CAS  Google Scholar 

  10. Mentzel T, Fletcher CDM (1997) Dedifferentiated liposarcoma: a clinicopathological study suggesting a closer relationship between myxoid and well-differentiated liposarcoma. Histopathology 30:457–463

    Article  PubMed  CAS  Google Scholar 

  11. Schneider-Stock R, Walter H, Radig K, Rys J, Bosse A, Kuhnen C, Hoang-Vu C, Roessner A (1998) MDM2 amplification and loss of heterozygosity at Rb and p53 genes: no simultaneous alterations on the oncogenesis of liposarcomas. J Cancer Res Clin Oncol 124:532–540

    Article  PubMed  CAS  Google Scholar 

  12. Sreekantaiah C, Karakousis CP, Leong SP, Sandberg AA (1991) Trisomy 8 as a nonrandom secondary change in myxoid liposarcoma. Cancer Genet Cytogenet 51:195–205

    Article  PubMed  CAS  Google Scholar 

  13. Tan GY, Chong YL, Ramesh K, Walford NQ, Tan JK (2004) Giant mixed-type perinephric liposarcoma. Int Urol Nephrol 36:319–322

    Article  PubMed  Google Scholar 

  14. Yamaguchi T, Suzuki H, Ishii N, Nakada T, Onmura Y, Matsushita S (1991) Retroperitoneal mixed type liposarcoma: a case report. Hinyokiki Kiyo 37:141–145

    CAS  Google Scholar 

Download references

 

Conflict of interest statement

We declare that we have no conflict of interest

Author information

Authors and Affiliations

  1. Dermatopathologische Gemeinschaftspraxis, Siemensstrasse 6/1, 88048, Friedrichshafen, Germany

    Thomas Mentzel, Gabriele Palmedo & Markus Hantschke

  2. Department of Pathology, Aurich, Germany

    Jörg Woziwodzki

  3. Department of Surgery, Varel, Germany

    Christian Beck

Authors
  1. Thomas Mentzel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gabriele Palmedo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Markus Hantschke
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jörg Woziwodzki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Christian Beck
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas Mentzel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mentzel, T., Palmedo, G., Hantschke, M. et al. Mixed-type liposarcoma: clinicopathological, immunohistochemical, and molecular analysis of a case arising in deep soft tissues of the lower extremity. Virchows Arch 453, 197–201 (2008). https://doi.org/10.1007/s00428-008-0624-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-008-0624-7

Keywords

Search

Navigation