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Low serum apolipoprotein A1/B ratio is associated with proliferative diabetic retinopathy in type 2 diabetes

  • Retinal Disorders
  • Published:
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Abstract

Background

The association between lipids and diabetic retinopathy (DR) remains unclear. Only a few studies have reported the association between proliferative diabetic retinopathy (PDR) and the serum concentrations of apolipoprotein A1 (apoA1), apolipoprotein B (apoB) and apolipoprotein E (apoE). So we investigated the lipid profile in type 2 diabetic patients of long duration with very mild nonproliferative diabetic retinopathy (NPDR) or PDR.

Methods

Serum samples were obtained from 25 type 2 diabetic patients with very mild NPDR and 25 type 2 diabetic patients with PDR, and the two groups were matched by diabetes duration and glycosylated hemoglobin (HbA1c) levels. The levels of total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, apoA1, apoB, and apoE were measured by enzymatic colorimetric, surfactant, and immunotubidimetric method.

Results

Compared with PDR subjects, very mild NPDR subjects were characterized by increased HDL cholesterol (P = 0.0433) and apoA1 (P = 0.0290) levels, higher HDL cholesterol/LDL cholesterol (P = 0.0377) and apoA1/apoB (P = 0.0061) ratio in serum. There were significant associations between the decreased apoA1 and low apoA1/apoB ratio in serum and PDR. Even after adjustment for age, decreased apoA1 level (P = 0.0304) and low apoA1/apoB ratio (P = 0.0218) in serum were significantly associated with PDR in type 2 diabetic patients of over 15 years’ duration.

Conclusions

Low apolipoprotein A1/apolipoprotein B ratio in serum was associated with PDR in type 2 diabetic patients of long duration.

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Acknowledgements

This study was supported by a grant from the Eleven-Five National Technology Support Program (Grant No. 2007BAI18B07), the 5010 Clinical Research Program of Sun Yat-sen University (Grant No. 2007036) and the National Nature Science Foundation in China (Grants No. 30872819, 30901642, and 11001280).

Financial support

The sponsors or funding organizations had no involvement /participation in the design or conduct of this research.

Conflict of interest

No conflicting relationship exists for any author.

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Authors and Affiliations

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Nan Road, Guangzhou, 510060, Guangdong, China

    Andina Hu, Yan Luo, Tao Li, Xiaoyan Ding, Xiaobo Zhu, Xueqin Wang & Shibo Tang

  2. Department of Statistical Science, School of Mathematics and Computational Science, Sun Yat-sen University, 135 Xingang W. Rd, Guangzhou, 510275, Guangdong, China

    Xiaobo Guo & Xueqin Wang

  3. Zhongshan Medical School, Sun Yat-sen University, 135 Xingang W. Rd, Guangzhou, 510275, Guangdong, China

    Xueqin Wang

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  1. Andina Hu
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  2. Yan Luo
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  3. Tao Li
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Correspondence to Shibo Tang.

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Hu, A., Luo, Y., Li, T. et al. Low serum apolipoprotein A1/B ratio is associated with proliferative diabetic retinopathy in type 2 diabetes. Graefes Arch Clin Exp Ophthalmol 250, 957–962 (2012). https://doi.org/10.1007/s00417-011-1855-x

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  • DOI: https://doi.org/10.1007/s00417-011-1855-x

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