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Resting-state functional connectivity associated with mild cognitive impairment in Parkinson’s disease

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Abstract

Cognitive impairment is common in PD, even in early stages. The construct of mild cognitive impairment has been used to identify clinically evident cognitive impairment without functional decline in PD patients (PD-MCI). The aim of the present study was to investigate brain connectivity associated with PD-MCI through RS-fMRI. RS-fMRI at 3T was collected in 42 PD patients and 20 matched healthy controls. Among PD patients, 21 were classified as having MCI (PD-MCI) and 21 as cognitively unimpaired (PD-nMCI) based on criteria for possible PD-MCI (level I category). Single-subject and group-level ICA was used to investigate the integrity of brain networks related to cognition in PD patients with and without MCI. Image data processing and statistical analysis were performed in BrainVoyager QX. In addition, we used VBM to test whether functional connectivity differences were related to structural abnormalities. PD-nMCI and PD-MCI patients compared with controls showed decreased DMN connectivity. PD-MCI patients, but not PD-nMCI, compared with controls, showed decreased functional connectivity of bilateral prefrontal cortex within the frontoparietal network. The decreased prefrontal cortex connectivity correlated with cognitive parameters but not with clinical variables. VBM analysis did not reveal any difference in local gray matter between patients and controls. Our findings suggest that an altered DMN connectivity characterizes PD patients, regardless of cognitive status, whereas a functional disconnection of the frontoparietal network could be associated with MCI in PD in the absence of detectable structural changes.

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Acknowledgments

We thank Dr. Alessandro Iavarone for his precious statistical contribution.

Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical standard

All participants provided written informed consent to the protocol that has been performed in accordance with the Declaration of Helsinki and approved by the local Ethics Committee.

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Authors and Affiliations

  1. Neurodegenerative Diseases Center, Department of Medicine and Surgery, University of Salerno, Via Allende, 84081, Baronissi, SA, Italy

    Marianna Amboni, Fabrizio Esposito, Marina Picillo, Roberto Erro & Paolo Barone

  2. Istituto di Diagnosi e Cura Hermitage-Capodimonte, Naples, Italy

    Marianna Amboni, Carmine Vitale, Alfonso Giordano & Paolo Barone

  3. Department of Neurology, Second University of Naples, Naples, Italy

    Alessandro Tessitore, Alfonso Giordano, Rosa de Micco, Daniele Corbo & Gioacchino Tedeschi

  4. Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands

    Fabrizio Esposito

  5. Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy

    Gabriella Santangelo

  6. University Parthenope, Naples, Italy

    Carmine Vitale

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  1. Marianna Amboni
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  2. Alessandro Tessitore
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  3. Fabrizio Esposito
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  4. Gabriella Santangelo
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  5. Marina Picillo
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  6. Carmine Vitale
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  7. Alfonso Giordano
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  8. Roberto Erro
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  9. Rosa de Micco
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  10. Daniele Corbo
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  11. Gioacchino Tedeschi
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  12. Paolo Barone
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Corresponding author

Correspondence to Paolo Barone.

Additional information

M. Amboni and A. Tessitore contributed equally to the manuscript.

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Amboni, M., Tessitore, A., Esposito, F. et al. Resting-state functional connectivity associated with mild cognitive impairment in Parkinson’s disease. J Neurol 262, 425–434 (2015). https://doi.org/10.1007/s00415-014-7591-5

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  • DOI: https://doi.org/10.1007/s00415-014-7591-5

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