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The role of mitochondria in neurodegenerative diseases

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Abstract

Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases, and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this field.

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Authors and Affiliations

  1. Clinical Neurology, Section for Neuromuscular Diseases and Neuropathies, University Hospital “Spedali Civili”, Pz.le Spedali Civili 1, 25100, Brescia, Italy

    Massimiliano Filosto, Maria Sofia Cotelli, Valentina Vielmi, Alice Todeschini, Valeria Gregorelli & Alessandro Padovani

  2. Clinical Neurology, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy

    Mauro Scarpelli, Paola Tonin & Giuliano Tomelleri

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  1. Massimiliano Filosto
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  2. Mauro Scarpelli
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  3. Maria Sofia Cotelli
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  4. Valentina Vielmi
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  5. Alice Todeschini
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Correspondence to Massimiliano Filosto.

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Filosto, M., Scarpelli, M., Cotelli, M.S. et al. The role of mitochondria in neurodegenerative diseases. J Neurol 258, 1763–1774 (2011). https://doi.org/10.1007/s00415-011-6104-z

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  • DOI: https://doi.org/10.1007/s00415-011-6104-z

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