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Clopidogrel-associated acute arthritis

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Abstract

A 54-year-old Japanese man was urgently admitted to our hospital because of “unmovable” polyarthralgia, high fever and pruritus. He had taken clopidogrel 3 weeks before this admission to prevent ischemic cerebrovascular events. On the laboratory values, acute phase reactants and serum IgE were elevated. Although his symptoms had promptly improved with non-steroidal anti-inflammatory drugs (NSAIDs) and cessation of the drug, the same phenomena were re-induced by re-administration of the drug. According to the above manifestations, he was diagnosed as suffering from clopidogrel-associated acute arthritis.

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Fig. 1

Abbreviations

Anti-CCP antibodies:

Anti-cyclic citrullinated peptide antibodies

CRP:

C-reactive protein

DLST:

Drug lymphocytes stimulation test

ESR:

Erythrocyte sedimentation rate

MRI:

Magnetic resonance imaging

NSAIDs:

Non-steroidal anti-inflammatory drugs

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Authors and Affiliations

  1. Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Shin-ya Kawashiri, Masatake Taguchi, Atsushi Kawakami & Katsumi Eguchi

Authors
  1. Shin-ya Kawashiri
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  2. Masatake Taguchi
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  3. Atsushi Kawakami
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  4. Katsumi Eguchi
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Corresponding author

Correspondence to Katsumi Eguchi.

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Kawashiri, Sy., Taguchi, M., Kawakami, A. et al. Clopidogrel-associated acute arthritis. Rheumatol Int 32, 449–450 (2012). https://doi.org/10.1007/s00296-009-1267-y

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  • DOI: https://doi.org/10.1007/s00296-009-1267-y

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