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Association Between Aflatoxin M1 Excreted in Human Urine Samples with the Consumption of Milk and Dairy Products

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Abstract

This study aimed to find the association between urinary aflatoxin M1 level and milk and dairy products consumption. Of 160 morning urine samples collected, aflatoxin M1 was detected in 61.3 % samples (n = 98) [mean ± SD = 0.0234 ± 0.0177 ng/mL; range = 0–0.0747 ng/mL]. Of these positive samples, 67.3 % (n = 66) had levels above the limit of detection. Respondents with intake of milk and dairy products above median (67.79 g/day) had significantly high level of AFM1 compared to those with low intake. A significant and positive association (φ = 0.286) was found between milk and dairy products consumption and urinary aflatoxin M1 level.

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References

  • Azmi MY, Junaidah R, Siti Mariam A, Safiah MY, Fatimah S, Norimah AK et al (2009) Body Mass Index (BMI) of adults: findings of the Malaysian Adult Nutrition Survey. Malays J Nutr 15:97–119

    Google Scholar 

  • Beltran E, Ibanez M, Sancho JV, Cortes MA, Yusa V, Hernandez F (2011) UPLC-MS/MS highly sensitive determination of aflatoxins, the aflatoxin metabolite M1 and ochratoxin A in baby food and milk. Food Chem 126:737–744

    Article  CAS  Google Scholar 

  • de Romero CA, Ferreira TRB, dos Santos Dias CT, Calori-Domingues MA, da Gloria EM (2010) Occurrence of AFM1 in urine samples of a Brazillian population and association with food consumption. Food Control 21:554–558

    Article  Google Scholar 

  • Desalegn B, Nanyakkara S, Harada KH, Hitomi T, Chandrajith R, Karunaratne U et al (2011) Mycotoxin detection in urine samples from patients with chronic kidney disease of uncertain etiology in Sri Lanka. Bull Environ Contam Toxicol 87:6–10

    Article  CAS  Google Scholar 

  • Food Safety Information System of Malaysia (FoSIM) (2012) Food Regulations 1985. Resource document. Ministry of Health. http://fsis2.moh.gov.my/fosimv2/HOM/frmHOMFARSecDetail.aspx?FAS_ID=45&FAC_ID=21&FAD_ID=594#. Accessed 14 February 2012

  • Heshmati A, Milani JM (2010) Contamination of UHT milk by aflatoxin M1 in Iran. Food Control 21:19–22

    Article  CAS  Google Scholar 

  • IARC (1993) Aflatoxin. In: Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC monograph on the evaluation of carcinogenic risk to humans, vol 56. International Agency for Research on Cancer, Lyon, pp 245–395

  • Jolly P, Jiang Y, Ellis W, Awuah R, Nnedu O, Philips T et al (2006) Determinants of aflatoxin levels in Ghanaians: sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices. Int J Hyg Environ Health 209:345–358

    Article  CAS  Google Scholar 

  • Jonsyn-Ellis FE (2000) Seasonal variation in exposure frequency and concentration levels of aflatoxin and ochratoxins in urine samples of boys and girls. Mycopathologia 152:35–40

    Article  Google Scholar 

  • Kabak B (2009) The fate of mycotoxins during thermal food processing. J Sci Food Agric 89:549–554

    Article  CAS  Google Scholar 

  • Kim EK, Shon DH, Ryu D, Park JW, Hwang HJ, Kim YB (2000) Occurrence of aflatoxin M1 in Korean dairy products determined by ELISA and HPLC. Food Addit Contam 17:59–64

    Article  CAS  Google Scholar 

  • Liu Y, Wu F (2010) Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 118:818–824

    Article  CAS  Google Scholar 

  • Lye MS, Ghazali AA, Mohan J, Alwin N, Nair RC (1995) An outbreak of acute hepatic encephalopathy due to severe aflatoxicosis in Malaysia. Am J Trop Med Hyg 53:68–72

    CAS  Google Scholar 

  • Ministry of Health, MOH (2006) Food consumption statistic of Malaysia 2002/2003 for adult population aged 18 to 19 years. Food Safety and Quality Division, Ministry of Health Malaysia, Kuala Lumpur

    Google Scholar 

  • Norimah AK, Safiah M, Jamal K, Haslinda S, Zuhaida H, Rohida S et al (2008) Food consumption patterns: findings from the Malaysian Adult Nutrition Survey (MANS). Malays J Nutr 14:25–39

    Google Scholar 

  • Purchase LFH, Steyn M, Rinsma R, Tustin RC (1972) Reduction of the aflatoxin M content of milks by processing. Food Cosmet Toxicol 10:383–387

    Article  CAS  Google Scholar 

  • Qian GS, Ross RK, Yu MC, Yuan JM, Gao YT, Henderson BE et al (1994) A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epidemiol Biomarkers Prev 3:3–10

    CAS  Google Scholar 

  • Reddy KRN, Farhana NI, Salleh B (2011) Occurrence of Aspergillus spp. and aflatoxin B1 in Malaysian foods used for human consumption. J Food Sci 76:T99–T104

    Article  CAS  Google Scholar 

  • Sabran, MR, Jamaluddin, R, Abdul Mutalib, MS (2012) Estimation of dietary AFB1 exposure through the level of AFM1 detected in human urine samples: A preliminary studiy. In: Chye FY, Lee JS, Siew CK, Noorakmar AW, Ramlah MR (eds) Proceedings on international conference on food science and nutrition. Universiti Malaysia Sabah, Sabah, pp 962–971

  • Sadia A, Jabbar MA, Deng Y, Hussain EA, Riffat S, Naveed S et al (2012) A survey of aflatoxin M1 in milk and sweets of Punjab, Pakistan. Food Control 26:235–240

    Article  CAS  Google Scholar 

  • Sun Z, Lu P, Gail MH, Pee D, Zhang Q, Ming L et al (1999) Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology 30:379–383

    Article  CAS  Google Scholar 

  • Suzana S, Noor Aini MY, Nik Shanita S, Rafidah G, Roslina A (2002) Atlas of food exchanges and portion sizes, 2nd edn. MDC Publishers Sdn Bhd, Kuala Lumpur

    Google Scholar 

  • Tee ES, Mohd Ismail N, Mohd Nasir A, Kathijah I (1997) Nutrient composition of Malaysian foods, 4th edn. Institute for Medical Research, Kuala Lumpur

    Google Scholar 

  • Zhu JQ, Zhang LS, Hu X, Xiao Y, Chen JS, Xu YC et al (1987) Correlation of dietary aflatoxin B1 levels with excretion of aflatoxin M1 in human urine. Cancer Res 47:1848–1852

    CAS  Google Scholar 

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Acknowledgments

Mohd Redzwan Sabran would like to thank the Ministry of Higher Education, Malaysia for financially supported his postgraduate studies.

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All the authors have declared that they do not have any potential conflicts of interest.

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Correspondence to Jamaluddin Rosita.

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Mohd Redzwan, S., Rosita, J., Mohd Sokhini, A.M. et al. Association Between Aflatoxin M1 Excreted in Human Urine Samples with the Consumption of Milk and Dairy Products. Bull Environ Contam Toxicol 89, 1115–1119 (2012). https://doi.org/10.1007/s00128-012-0853-y

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  • DOI: https://doi.org/10.1007/s00128-012-0853-y

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