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A review on heme oxygenase-1 induction: is it a necessary evil

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Abstract

Heme oxygenase-1 (HO-1) is considered to be the main protein in diseases arising as a result of oxidative and inflammatory insults. Tremendous research has been carried out on HO-1 since years, pertaining its cytoprotective effect against oxidative injury and other cellular stresses. HO-1, by regulating intracellular levels of pro-oxidant heme, or by other benefits of its by-products such as carbon monoxide (CO) and biliverdin (BV) had become an important candidate protein to be up-regulated to combat diverse stressful events. Although the beneficial effects of HO-1 induction have been reported in a number of cells and tissues, a growing body of evidence indicates that this increased HO-1 expression may lead to the progression of several diseases such as neurodegeneration, carcinogenesis. But it is not clear, what accounts for the increased expression of HO-1 in cells and tissues. The observed friendly role of HO-1 in a wide range of stress conditions since times is now doubtful. Therefore, more studies are needed to elucidate the exact role of HO-1 in various stressful events. Being more concise, elucidating the effect of HO-1 up-regulation on critical genes involved in particular diseases such as cancer will help to a larger extent to comprehend the exact role of HO-1. This review will assist in understanding the dual role (protective and detrimental) of HO-1 and the signaling pathway involved and will help in unraveling the doubtful role of HO-1 induction.

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Acknowledgements

Council of Scientific and Industrial Research (CSIR) GOI, New Delhi is acknowledged for providing fellowship to Ajaz Ahmad Waza (CSIR-RA fellow) (9/251 (0077)/2k17).

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Authors and Affiliations

  1. Centre of Research for Development (CORD), University of Kashmir, Srinagar, Jammu and Kashmir, India

    Ajaz Ahmad Waza, Sajad Ali & Shabir Ahmad Bhat

  2. Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Zeenat Hamid

  3. Maulana Azad Medical College and Associated Hospitals, New Delhi, India

    Musadiq Ahmad Bhat

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  1. Ajaz Ahmad Waza
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Waza, A.A., Hamid, Z., Ali, S. et al. A review on heme oxygenase-1 induction: is it a necessary evil. Inflamm. Res. 67, 579–588 (2018). https://doi.org/10.1007/s00011-018-1151-x

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  • DOI: https://doi.org/10.1007/s00011-018-1151-x

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