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Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis

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Abstract

Objective

The aim of this study was to determine whether tumor necrosis factor alpha inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations.

Methods

The authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and RA susceptibility.

Result

A total of ten comparative studies were included in this meta-analysis, which showed an association between the two allele of rs6920220 and RA in all study subjects [odds ratio (OR) 1.216, 95% confidence interval (CI) 1.166–1.269, p < 1.0 × 10−9]. The two allele of rs6920220 was also significantly associated with RA in Europeans only (OR 1.227, 95% CI 1.175–1.282, p < 1.0 × 10−9). Meta-analysis revealed no association between the two allele of the rs10499194 polymorphism and RA in Europeans, but a significant association was found in Asians (OR 1.254, 95% CI 1.101–1.429, p = 6.7 × 10−4). Furthermore, an association was found between the two allele of rs2230926 and RA in all study subjects (OR 1.390, 95% CI 1.214–2.331, p = 1.9 × 10−6).

Conclusions

This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.

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Acknowledgments

This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).

Conflict of interest

We have no financial and non-financial conflicts of interest.

Author information

Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

    Young Ho Lee, Sung Jae Choi, Jong Dae Ji & Gwan Gyu Song

  2. Division of Rheumatology, Department of Internal Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, Korea

    Sang-Cheol Bae

  3. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea

    Young Ho Lee

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  1. Young Ho Lee
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  2. Sang-Cheol Bae
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Correspondence to Young Ho Lee.

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Responsible Editor: Andras Falus.

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Lee, Y.H., Bae, SC., Choi, S.J. et al. Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis. Inflamm. Res. 61, 635–641 (2012). https://doi.org/10.1007/s00011-012-0455-5

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  • DOI: https://doi.org/10.1007/s00011-012-0455-5

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