Abstract
The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatements were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg ofΔ 9 tetrahydrocannabinol (THC), and 0.75 ml/kg of 95% ethanol together with 15 mg of THC. The marijuana-induced delay in recovery is doserelated. Both drugs produce delayed recovery for at least 2 h after drug ingestion. The combined alcohol and marijuana treatment produces little more than the effect produced by either drug alone, suggesting some antagonism between the drugs — a suggestion supported by a significantly lower blood alcohol level for the alcohol dose when combined with marijuana than when taken alone.
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Adams, A.J., Brown, B., Haegerstrom-Portnoy, G. et al. Marijuana, alcohol, and combined drug effects on the time course of glare recovery. Psychopharmacology 56, 81–86 (1978). https://doi.org/10.1007/BF00571413
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DOI: https://doi.org/10.1007/BF00571413