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Striatal glutamatergic mechanisms and extrapyramidal movement disorders

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Abstract

The nonphysiologic stimulation of striatal dopaminergic receptors, as a result of disease- or drug-related denervation or intermittent excitation, triggers adaptive responses in the basal ganglia which contribute to the appearance of parkinsonian symptoms and later to the dyskinesias and other alterations in motor response associated with dopaminergic therapy. Current evidence suggests that these altered responses involve activation of signal transduction cascades in striatal medium spiny neurons linking dopaminergic to coexpressed ionotropic glutamatergic receptors of theN-methyl-d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) classes. These intraneuronal signaling pathways appear capable of modifying the phosphorylation state of NMDA and AMPA receptor subunits; resultant sensitization enhances cortical glutamatergic input which in turn modifies striatal output in ways that compromise motor behavior. The regulation of these spiny neuron glutamate receptors can also be affected by the activation state of coexpressed nondopaminergic receptors as well as by changes associated with Huntington's disease. These observations lend new insight into molecular mechanisms contributing to the integration of synaptic inputs to spiny neurons. They also suggest novel approaches to the pharmacotherapy of extrapyramidal motor dysfunction.

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References

  • Ahlskog JE and MD Muenter (2001) Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature.Mov. Disord. 16, 448–458.

    Article  PubMed  CAS  Google Scholar 

  • Ahn S, DD Ginty and DJ Linden (1999) A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB.Neuron 23, 559–568.

    Article  PubMed  CAS  Google Scholar 

  • Andersson M, A Hilbertson and MA Cenci (1999) Striatal fosB expression is causally linked with L-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease.Neurobiol. Dis. 6, 461–474.

    Article  PubMed  CAS  Google Scholar 

  • Anglade P, A Mouatt-Prigent, Y Agid and E Hirsch (1996) Synaptic plasticity in the caudate nucleus of patients with Parkinson's disease.Neurodegeneration 5, 121–128.

    Article  PubMed  CAS  Google Scholar 

  • Bartsch D, A Casadio, KA Karl, P Serodio and ER Kandel (1998) CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation.Cell 95, 211–223.

    Article  PubMed  CAS  Google Scholar 

  • Bayer KU, P De Koninck, AS Leonard, JW Hell and H Schulman (2001) Interaction with the NMDA receptor locks CaMKII in an active conformation.Nature 411, 801–805.

    Article  PubMed  CAS  Google Scholar 

  • Bibb JA, JS Chen, JR Taylor, P Svenningsson, A Nishi, GL Snyder, Z Yan, ZK Sagawa, CC Ouimet, AC Nairn, EJ Nestler and P Greengard (2001) Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.Nature 410, 376–380.

    Article  PubMed  CAS  Google Scholar 

  • Blanchet PJ, LV Metman, MM Mouradian and TN Chase (1996) Acute pharmacologic blockade of dyskinesias in Parkinson's disease.Mov. Disord. 11, 580–581.

    Article  PubMed  CAS  Google Scholar 

  • Blanchet PJ, SM Papa, LV Metman, MM Mouradian and TN Chase (1997) Modulation of levodopa-induced motor response complications by NMDA antagonists in Parkinson's disease.Neurosci. Biobehav. Rev. 21, 447–453.

    Article  PubMed  CAS  Google Scholar 

  • Blanchet PJ, S Konitsiotis and TN Chase (1998) Amantadine reduces levodopa-induced dyskinesias in parkinsonian monkeys.Mov. Disord. 13, 798–802.

    Article  PubMed  CAS  Google Scholar 

  • Blanchet PJ, S Konitsiotis, N Whitmore, R Woodward and TN Chase (1999) Different effects of subunit specific NMDA antagonists in parkinsonian monkeys.J. Pharmacol. Exp. Ther. 290, 1034–1040.

    PubMed  CAS  Google Scholar 

  • Cain DP (1997) LTP, NMDA, genes and learning.Curr. Opin. Neurobiol. 7, 235–242.

    Article  PubMed  CAS  Google Scholar 

  • Calabresi P, P Giacomini, D Centonze and G Bernardi (2000) Levodopa-induced dyskinesia: a pathological form of striatal synaptic plasticity?Ann Neurol. 47 (4 Suppl 1), S60-S8.

    PubMed  CAS  Google Scholar 

  • Cenci MA, CS Lee and A Björklund (1998) L-Dopa-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin and glutamic acid decarboxylase mRNA.Eur. J. Neurosci. 10, 2694–2706.

    Article  PubMed  CAS  Google Scholar 

  • Cenci MA, A Tranberg, M Andersson and A Hilbertson (1999) Changes in the regional and compartmental distribution of FodB-and JunB-like immunoreactivity induced in the dopamine-denervated rat striatum by acute or chronic L-dopa treatment.Neuroscience 94, 515–527.

    Article  PubMed  CAS  Google Scholar 

  • Centonze D, B Picconi, P Gubellini, G Bernardi and P Calabresi (2001) Dopaminergic control of synaptic plasticity in the dorsal striatum.Eur. J. Neurosci. 6, 1071–1077.

    Article  Google Scholar 

  • Cepeda C and MS Levine (1998) Dopamine andN-methyl-D-aspartate receptor interactions in the neostriatum.Dev. Neurosci. 20, 1–18

    Article  PubMed  CAS  Google Scholar 

  • Cervo L and R Samanin (1996) Effects of dopaminergic and glutamatergic receptor antagonists on the establishment and expression of conditioned locomotion to cocaine in rats.Brain Res. 731, 31–38.

    Article  PubMed  CAS  Google Scholar 

  • Chase TN and JD Oh (2000a) Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism.Trends Neurosci. 23, S86-S91.

    Article  PubMed  CAS  Google Scholar 

  • Chase TN and JD Oh (2000b) Striatal mechanisms and pathogenesis of parkinsonian signs and motor complications.Ann. Neurol. 4 (Suppl 1), S122-S129.

    Google Scholar 

  • Chase TN, JD Oh and S Konitsiotis (2000) Antiparkinsonian and antidyskinetic activity of drugs targeting central glutamatergic mechanisms.J. Neurol. 247 (Suppl 2), 36–42.

    Google Scholar 

  • Chen Q and A Reiner (1996) Cellular distribution of the NMDA receptor NR2A/2B subunits in the rat striatum.Brain Res. 743, 346–352.

    Article  PubMed  CAS  Google Scholar 

  • Clarke CE, MA Sambrook, IJ Mitchell and ARH Crossman (1987) Levodopa-induced dyskinesia and response fluctuations in primates rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).J. Neurol. Sci. 78, 273–280.

    Article  PubMed  CAS  Google Scholar 

  • Crump FT, KS Dillman and AM Craig (2001) cAMP-dependent protein kinase mediates activity-regulated synaptic targeting of NMDA receptors.J. Neurosci. 21, 5079–5088.

    PubMed  CAS  Google Scholar 

  • Danysz W, CG Parons, J Kornhuber, WJ Schmidt and G Quack (1997) Amino-adamentanes as NMDA receptor antagonists and antiparkinsonian agents-preclinical studies.Neurosci. Biobehav. Rev. 21, 455–468.

    Article  PubMed  CAS  Google Scholar 

  • Das S, M Grunert, L Williams and SR Vincent (1997) NMDA and D1 receptors regulate the phosphorylation of CREB and the induction of c-fos in striatal neurons in primary culture.Synapse 25, 227–233.

    Article  PubMed  CAS  Google Scholar 

  • Del Dotto P, N Pavese, G Gambaccini, S Bernardini, LV Metman, TN Chase and U Bonuccelli (2001) Intravenous amantadine improves levadopa-induced dyskinesias: an acute double-blind placebo-controlled study.Mov. Disord. 16, 515–520.

    Article  PubMed  Google Scholar 

  • Dunah AW and DG Standaert (2001) Dopamine D1 receptor-dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane.J. Neurosci. 21, 5546–5558.

    PubMed  CAS  Google Scholar 

  • Engber TM, Z Susel, S Kuo, CR Gerfen and TN Chase (1991) Levodopa replacement therapy alters enzyme activities in striatum and neuropeptide content in striatal output regions of 6-hydroxydopamine lesioned rats.Brain Res. 552, 113–118.

    Article  PubMed  CAS  Google Scholar 

  • Engber TM, RC Boldry, S Kuo and TN Chase (1992) Dopaminergic modulation of striatal neuropeptides, differential effects of D1 and D2 receptor stimulation on somatostatin, neuropeptide Y, neurotensin, dynorphin and enkephalin.Brain Res. 581, 261–268.

    Article  PubMed  CAS  Google Scholar 

  • Engber TM, SM Papa, RC Boldry and TN Chase (1994) NMDA receptor blockade reverses motor response alterations induced by levodopa.Neuroreport 5, 2586–2588.

    Article  PubMed  CAS  Google Scholar 

  • Freund TF, JF Powell and AD Smith (1984) Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines.Neuroscience 4, 1189–1215.

    Article  Google Scholar 

  • Gerfen CR (1992) The neostriatal mosiac: multiple levels of compartmental organization in the basal ganglia.Ann. Rev. Neurosci. 15, 285–320.

    Article  PubMed  CAS  Google Scholar 

  • Gerfen CR, TM Engber, LC Mahan, Z Susel, TN Chase, FJ Monsma Jr and DR Sibley (1990) D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons.Science 250, 1429–1432.

    Article  PubMed  CAS  Google Scholar 

  • Ginty DD (1997) Calcium regulation of gene expression: isn't that spatial?Neuron 2, 183–186.

    Article  Google Scholar 

  • Gomez-Mancilla B and PJ Bedard (1993) Effect of nondopaminergic drugs on L dopa-induced dyskinesias in MPTP-treated monkeys.Clin. Neuropharmacol. 16, 418–427.

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez GA, P Menzel, J Leonard, WH Fischer and MR Montminy (1991) Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB.Mol. Cell. Biol. 11, 1306–1312.

    PubMed  CAS  Google Scholar 

  • Goto S, A Hirano A and RR Rojas-Corona (1989) Immunohistochemical visualization of afferent nerve terminals in human globus pallidus and its alteration in neostriatal neurodegenerative disorders.Acta Neuropathol. (Berl.) 78, 543–550.

    Article  CAS  Google Scholar 

  • Graybiel AM (1998) The basal ganglia and chunking of action repertoires.Neurobiol. Learn. Mem. 1, 119–136.

    Article  Google Scholar 

  • Graybiel AM (2000) The basal ganglia.Curr. Biol. 14, R509-R511.

    Article  Google Scholar 

  • Greengard P, PB Allen and AC Nairn (1999) Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.Neuron 23, 435–447.

    Article  PubMed  CAS  Google Scholar 

  • Grosshans DR and MD Browning (2001) Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor.J. Neurochem. 76, 737–744.

    Article  PubMed  CAS  Google Scholar 

  • Gurd JW (1997) Protein tyrosine phosphorylation: Implications for synaptic function.Neurochem. Int. 31, 635–649.

    Article  PubMed  CAS  Google Scholar 

  • Hollmann M and S Heinemann (1994) Cloned glutamate receptors.Ann. Rev. Neurosci. 17, 31–108.

    Article  PubMed  CAS  Google Scholar 

  • Hope BT, HE Nye, MB Kelz, DW Self, MJ Ladarola, Y Nakabeppu, RS Duman and EJ Nestlet (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.Neuron 13, 1235–1244.

    Article  PubMed  CAS  Google Scholar 

  • Hornykiewicz O (1998) Biochemical aspects of Parkinson's disease.Neurology 51, S2-S9.

    PubMed  CAS  Google Scholar 

  • Hu SC, J Chrivia and A Ghosh (1999) Regulation of CBP-mediated transcription by neuronal calcium signaling.Neuron 22, 799–808.

    Article  PubMed  CAS  Google Scholar 

  • Huang EP and CF Stevens (1998) The matter of mind: molecular control of memory.Essays Biochem. 33, 165–178.

    PubMed  CAS  Google Scholar 

  • Impey S, DM Smith, K Obrietan, R Donahue, C Wade and DR Storm (1998) Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning.Nature Neurosci. 1, 595–601.

    Article  PubMed  CAS  Google Scholar 

  • Karcz-Kubicha M, G Quack and W Danysz (1998) Amantadine attenuates response alterations resulting from repetitive L-DOPA treatment in rats.J. Neural Transm. 105, 1229–1236

    Article  PubMed  CAS  Google Scholar 

  • Kelz MB, JS Chen, WA Carlezon, K Whisler, L Gilden, AM Beckmann, C Steffen, YJ Zhang, L Marotti, DW Self, T Tkatch, G Baranauskas, DJ Surmeier, RL Neve, RS Duman, MR Picciotto and EJ Nestler (1999) Expression of the transcriptional factor ΔFosB in the brain controls sensitivity to cocaine.Nature 401, 272–276.

    Article  PubMed  CAS  Google Scholar 

  • Khan SM, TS Smith and JP Bennett (1999) Effects of single and multiple treatments with L-dihydroxyphenylalanine (L-DOPA) on dopamine receptor-G protein interactions and supersensitive immediate early gene responses in striata of rats after reserpine treatment or with unilateral nigrostriatal lesions.J. Neurosci. Res. 55, 55–71.

    Article  Google Scholar 

  • Klockgether T, L Turski, T Honore, Z Zhang, DM Gash, R Kurlan and JT Greenamyre (1991) The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys.Ann. Neurol. 30, 717–723.

    Article  PubMed  CAS  Google Scholar 

  • Konitsiotis S, PJ Blanchet, L Verhagen, E Lamers and TN Chase (2000) AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys.Neurology 8, 1589–1595.

    Google Scholar 

  • Kotter R (1994) Postsynaptic integration of glutamatergic and dopaminergic signals in the striatum.Prog. Neurobiol. 44, 163–196.

    Article  PubMed  CAS  Google Scholar 

  • Lan JY, VA Skeberdis, T Jover, SY Grooms, Y Lin, RC Araneda, X Zheng, MVL Bennett and RS Zukin (2001) Protein kinase C modulates NMDA receptor trafficking and gating.Nature Neurosci. 4, 382–390.

    Article  PubMed  CAS  Google Scholar 

  • Lew J, Q Huang, Q Zhong, R Winkfein, R Aebersold, T Hunt and J Wang (1994) A brain-specific activator of cyclin-dependent kinase 5.Nature 271, 423–426.

    Article  Google Scholar 

  • Liao GY, DA Wagner, MH Hsu and JP Leonard (2001) Evidence for direct protein kinase-C mediated modulation ofN-methyl-D-aspartate receptor current.Mol. Pharmacol. 59, 960–964.

    PubMed  CAS  Google Scholar 

  • Luquin MR, JA Obesbo, J Laguma, J Guillen and JM Martinez-Lage (1993) the AMPA receptor antagonist NBQX does not alter the motor response induced by selective dopamine agonists in MPTP-treated monkeys.Eur. J. Pharmaol. 235, 297–300.

    Article  CAS  Google Scholar 

  • Marin C, S Papa, TM Engber, M Bonastre, E Tolosa and TN Chase (1996) MK-801 prevents levodopa-induced motor response alterations in parkinsonian rats.Brain Res. 736, 202–205.

    Article  PubMed  CAS  Google Scholar 

  • Marin C, A Jimenez, M Bonastre, TN Chase and E Tolosa (2000) Non-NMDA receptor-mediated mechanisms in levodopa-induced motor response alterations in parkinsonian rats.Synapse 36, 267–274.

    Article  PubMed  CAS  Google Scholar 

  • Mayer ML and GL Westbrook (1987) The physiology of excitatory amino acids in the vertebrate central nervous system.Prog. Neurobiol. 3, 197–276.

    Article  Google Scholar 

  • McDonald BJ, HJ Chung and RL Huganir (2001) Identification of protein kinase C phosphorylation sites within the AMPA.Neuropharmacology 6, 672–679.

    Article  Google Scholar 

  • Menegoz M, LF Lau, D Herve, RL Huganir and JA Girault (1995) Tyrosine phosphorylation of NMDA receptor in rat striatum: effects of 6-OH-dopamine lesions.Neuroreport 7, 125–128.

    PubMed  CAS  Google Scholar 

  • Merello M, MI Nouzeilles, A Cammarota and R Leiguarda (1999) Effect of memantine (NMDA antagonist) on Parkinson's disease: a double blind crossover randomized study.Clin. Neuropharmacol. 22, 273–276.

    PubMed  CAS  Google Scholar 

  • Meshul CK and C Allen (2000) Haloperidol reverses the changes in striatal glutamatergic immunolabeling following a 6-OHDA lesion.Synapse 2, 129–142.

    Article  Google Scholar 

  • Metman LV, PJ Blancet, P van den Munckhof, P Del Dotto, R Natte and TN Chase (1998a) A trial of dextromethorphan in parkinsonian patients with motor response complications.Mov. Disord. 13, 414–417.

    Article  Google Scholar 

  • Metman LV, PD Dotto, P van den Munckhof, J Fang, MM Mouradian and TN Chase (1998b) Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease.Neurology 50, 1323–1329.

    CAS  Google Scholar 

  • Metman LV, PD Dotto, R Natte, P van den Munckhof and TN Chase (1998c) Dextromethorphan improves levodopa-induced dyskinesias in Parkinson's disease.Neurology 51, 203–206.

    CAS  Google Scholar 

  • Mitchell IJ and CB Carroll (1997) Reversal of parkinsonian symptoms in primates by antagonism of excitatory amino acid transmission: potential mechanisms of action.Neurosci. Biobehav. Rev. 21, 469–475.

    Article  PubMed  CAS  Google Scholar 

  • Mouradian MM, IJ Heuser, F Baronti and TN Chase (1990) Modification of central dopaminergic mechanisms by continuous levodopa therapy for advanced Parkinson's disease.Ann. Neurol. 27, 18–23.

    Article  PubMed  CAS  Google Scholar 

  • Nicoll RA and RC Malenka (1995) Contrasting properties of two forms of long-term potentiation in the hippocampus.Nature 377, 115–118.

    Article  PubMed  CAS  Google Scholar 

  • Nishi A, JA Bibb, GL Snyder, H Higashi, AC Nairn and P Greengard (2000) Amplification of dopaminergic signaling by a positive feedback loop.Proc. Natl. Acad. Sci. USA 97, 12840–12845.

    Article  PubMed  CAS  Google Scholar 

  • Oh JD, PD Dotto and TN Chase (1997) Protein kinase A inhibitor attenuates levodopa-induced motor response alterations in the hemi-parkinsonian rat.Neurosci. Lett. 228, 5–8.

    Article  PubMed  CAS  Google Scholar 

  • Oh JD, D Russell CL Vaughan and TN Chase (1998) Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: Effect of dopaminergic denervation and levodopa administration.Brain Res. 813, 150–159.

    Article  PubMed  CAS  Google Scholar 

  • Oh JD, CL Vaughan and TN Chase (1999), Effect of dopamine denervation and dopamine agonist administration on serine phosphorylation of striatal NMDA receptor subunits.Brain Res. 821, 433–442.

    Article  PubMed  CAS  Google Scholar 

  • Ozawa S, H Kamiya and K Tsuzuki (1998) Glutamate receptors in the mammalian central nervous system.Prog. Neurobiol. 54, 581–618.

    Article  PubMed  CAS  Google Scholar 

  • Papa SM and TN Chase (1996) Levodopa-induced dyskinesias improved by a glutamate antagonist in Parkinsonian monkeys.Ann. Neurol. 39, 574–578.

    Article  PubMed  CAS  Google Scholar 

  • Papa SM, TM Engber AM Kask and TN Chase (1994) Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration.Brain Res. 662, 69–74.

    Article  PubMed  CAS  Google Scholar 

  • Papa SM, RC Boldry, TM Engber, AM Kask and TN Chase (1995) Reversal of levodopa-induced motor fluctuations in experimental parkinsonism by NMDA receptor blockade.Brain Res. 701, 13–18.

    Article  PubMed  CAS  Google Scholar 

  • Parent A and F Cicchetti (1998) The current model of basal ganglia organization under scrutiny.Mov. Disord. 2, 199–202.

    Article  Google Scholar 

  • Parent A, MC Asselin and PY Cote (1996) Dopaminergic regulation of peptide gene expression in the striatum of normal and parkinsonian monkeys.Adv. Neurol. 69, 73–77.

    PubMed  CAS  Google Scholar 

  • Pietruck C, G-X Xie, M Sharma, T Meuser and PP Palmer (1999) Multiple splice patterns of cyclic AMP response element-binding protein mRNA in the central nervous system of the rat.Mol. Brain Res. 69, 286–289.

    Article  PubMed  CAS  Google Scholar 

  • Pittenger C and E Kandel (1998) A genetic switch for long-term memory.Life Sci. 321, 91–96.

    CAS  Google Scholar 

  • Quinn PG (1993) Distinct activation domains within cAMP response element-binding protein (CREB) mediate basal and cAMP-stimulated transcription.J. Biol. Chem. 268, 16999–17009.

    PubMed  CAS  Google Scholar 

  • Reiner A, R Albin, KD Anderson, CJ D'Amato, JB Penney and AB Young (1988) Differential loss of striatal projection neurons in Huntington's disease.Proc. Natl. Acad. Sci. USA 85, 5733–5737.

    Article  PubMed  CAS  Google Scholar 

  • Sachdev PS (2000) The current status of tardive dyskinesia.Aust. NZ J. Psychiatry 3, 355–369.

    Article  Google Scholar 

  • Schultz W (1994) Behavior-related activity of primate dopamine neurons.Rev. Neurol. 150, 634–639.

    PubMed  CAS  Google Scholar 

  • Sheng M, MA Thompson and ME Greenberg (1991) CREB, a Ca(2+) regulated transcription factor phosphorylated by calmodulin-dependent kinase.Science 252, 1427–1430.

    Article  PubMed  CAS  Google Scholar 

  • Silva AJ, JH Kogan, PW Frankland and S Kida (1998) CREB and memory.Ann. Rev. Neurosci. 21, 127–148.

    Article  PubMed  CAS  Google Scholar 

  • Smith Y, BD Bennett, JP Bolam, A Parent and AF Sadikot (1994) Synaptic relationships between dopaminergic afferents and cortical or thalamic input in the sensorimotor territory of the striatum in monkey.J. Comp. Neurol. 1, 1–19.

    Article  Google Scholar 

  • Snyder GL, PB Allen, AA Fienberg, CG Valle, RL Huganir, AC Nairn and P Greengard (2000) Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulantsin vivo.J. Neurosci. 12, 4480–4488.

    Google Scholar 

  • Snyder GL, Z Yan, S Galdi, PB Allen, AA Feinberg, JA Bibb, RL Huganir, AC Nairn and P Greengard (2001) A D1-receptor/PKA/DARPP-32/PPI pathway regulates AMPA receptor phosphorylation and conductance in the neostriatum.Brit. J. Pharmacol. 133, 268.

    Google Scholar 

  • Sommer B, K Keinanen, TA Verdoorn, W Wisden, N Burnashev, A Herb, M Kohler, T Takagi, B Sakmann and PH Seeburg (1990) flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.Science 249, 1580–1585.

    Article  PubMed  CAS  Google Scholar 

  • Suen PC, K Wu, JL Xu, SY Lin, ES Levine and IB Black (1998) NMDA receptor subunits in the postsynaptic density of rat brain: expression and phosphorylation by endogenous protein kinases.Mol. Brain Res. 59, 215–228.

    Article  PubMed  CAS  Google Scholar 

  • Sun Y, A Savanenin, PH Reddy and YF Liu (2001) Polyglutamine-expanded huntingtin promotes sensitization ofN-methyl-D-aspartate receptors via post-synaptic density 95.J. Biol. Chem. 27, 24713–24718.

    Article  Google Scholar 

  • Swope SL, SI Moss, LA Raymond and RL Huganir (1999) Regulation of ligand-gated ion channels by protein phosphorylation.Adv. Second Messenger Phosphoprot. Res. 33, 49–78.

    CAS  Google Scholar 

  • Tingley WG, MD Ehlers, K Kameyama, C Doherty, JB Ptak, CT Riley and RL Huganir (1997) Characterization of protein kinase A and protein kinase C phosphorylation of theN-methyl-D-aspartate receptor NR1 subunit using phosphorylation site specific antibodies.J. Biol. Chem. 72, 5157–5166.

    Google Scholar 

  • Ulas J and C Cotman (1996) Dopaminergic denervation of striatum results in elevated expression of NR2A subunit.J. Neuroreport 7, 1789–1793.

    Article  CAS  Google Scholar 

  • Verhagen L, M Morris, C Farmer, M Gillespie, J Wuu and TN Chase (2001) A double-blind placebo-controlled crossover study of the effect of amantadine on chorea in Huntington's disease.Neurology 56 (Suppl 3), A386.

    Google Scholar 

  • Vonsattel JP and M DiFiglia (1998) Huntington disease.J. Neuropathol. Exp. Neurol. 5, 369–384.

    Article  Google Scholar 

  • Westbrook GL (1994) Glutamate receptor update.Curr. Opin. Neurobiol. 3, 337–346.

    Article  Google Scholar 

  • Wirshing WC (2001) Movement disorders associated with neuroleptic treatment.J. Clin. Psychiatry 62 (Suppl 21), 15–18.

    PubMed  CAS  Google Scholar 

  • Wollmuth LP, T Kuner, PH Seeburg and B Sakmann (1996) Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels.J. Physiol. (Lond.) 491, 779–797.

    CAS  Google Scholar 

  • Yu XM, R Askalan, GJ Keil II and MW Salter (1997) NMDA channel regulation by channel-associated protein tyrosine kinase Src.Science 275, 674–678.

    Article  PubMed  CAS  Google Scholar 

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Chase, T.N., Bibbiani, F. & Oh, J.D. Striatal glutamatergic mechanisms and extrapyramidal movement disorders. neurotox res 5, 139–145 (2003). https://doi.org/10.1007/BF03033378

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