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Cefprozil : A Review

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Abstract

Cefprozil is a novel third generation, broad-spectrum oral cephalosporin with activity against a spectrum of aerobic gram-negative and positive bacteria, as well as certain anaerobes. The beta-lactamase stability of cefprozil may exceed that of other oral cephalosporins for some important pathogens. Cefprozil may be a suitable alternative to several other commonly used beta-lactams and cephalosporins in the treatment of mild to moderate upper and lower respiratory tract infections including sinusitis, otitis media, pharyngitis/tonsillitis, secondary bacterial infection of acute bronchitis, and acute bacterial exacerbations of chronic bronchitis, and skin and skin structure infections in children. Available data indicate the safety of cefprozil in both pediatric and adult population.

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References

  1. Thornsberry C. Review of the in vitro anti bacterial activity of Cefprozil, a new oral cephalosporin.Clin Infect Dis 1992; 149(suppl2): S189-S194.

    Google Scholar 

  2. Gainer RB. Cefprozil, a new cephalosporin, its use in various clinical trials.South Med J 1995; 88:338–346.

    PubMed  Google Scholar 

  3. Wiseman LR, Benfield P. Cefprozil. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic potential.Drugs 1993; 45:295–317.

    PubMed  CAS  Google Scholar 

  4. Thornberry C, Brown SD, Yee Cet al. Increasing penicillin resistance in Streptococcus pneumoniae in the US effect on susceptibility to oral cephalosporins.Infect Med 1993;10(suppl D):15–24.

    Google Scholar 

  5. Fung-Tomc JC, Huczko E, Stickle Tet al. Antibacterial activities of Cefprozil compared with those of 13 oral cephems and 3 macrolides.Antimicrob Agents Chemother 1995; 39:533–538.

    PubMed  CAS  Google Scholar 

  6. Wise R. Comparative microbiological activity and pharmacokinetics of Cefprozil.Eur J Clin Microbiol Infect Dis 1994; 13:839–845.

    Article  PubMed  CAS  Google Scholar 

  7. Cappelletty DM, Rybak M. Bactericidal activities of cefprozil, penicillin, cefaclor, cefixime, and loracarbef against penicillin-susceptible and-resistant Streptococcus pneumoniae in an in vitro pharmacodynamic infection model.Antimicrob Agents and Chemother 1996; 40:1148–1152.

    CAS  Google Scholar 

  8. Barbhaiya RH, Gleason CR, Shyu WCet al. Phase I study of single-dose BMY-28100, a new oral cephalosporin.Antimicrob Agents Chemother 1990; 34:202–205.

    PubMed  CAS  Google Scholar 

  9. Barbhaiya RH, Shukla UA, Gleason CRet al. Phase I study of multiple dose cefprozil and comparison with cefaclor.Antimicrob Agents Chemother 1990; 34:1198–1203.

    PubMed  CAS  Google Scholar 

  10. Barbhaiya RH, Shukla UA, Gleason CRet al. Comparison of the effects of food on the pharmacokinetics of cefprozil and cefaclor.Antimicrob Agents Chemother 1990; 34:1210–1213.

    PubMed  CAS  Google Scholar 

  11. Nagano K, Maeda H, Yanagi Tet al. Pharmacokinetic and clinical studies of cefprozil fine granules in children.Jpn J Antibiot 1992; 45:1736–1744.

    PubMed  CAS  Google Scholar 

  12. Barriere SL. Pharmacology and pharmacokinetics of cefprozil.Clin Infect Dis 1992; 14 Suppl 2: S184-S188.

    PubMed  Google Scholar 

  13. Shyu WC, Wilber RB, Pittman KA, Garg DC, Barbhaiya RH. Pharmacokinetics of cefprozil in healthy subjects and patients with hepatic impairment.J Clin Pharmacol 1991; 31:372–376.

    PubMed  CAS  Google Scholar 

  14. Barbhaiya RH, Shukla UA, Gleason CR, Shyu WC, Wilber RB, Pittman KA. Comparison of cefprozil and cefaclor pharmacokinetics and tissue penetration.Antimicrob Agents Chemother 1990; 34:1204–1209.

    PubMed  CAS  Google Scholar 

  15. Shyu WC, Reilly J, Campbell DA, Wilber RB, Barbhaiya RH. Penetration of cefprozil into tonsillar and adenoidal tissues.Antimicrob Agents Chemother 1993; 37:1180–1183.

    PubMed  CAS  Google Scholar 

  16. Shyu WC, Haddad J, Reilly Jet al. Penetration of cefprozil into middle ear fluid of patients with otitis media.Antimicrob Agents Chemother 1994; 38:2210–2212.

    PubMed  CAS  Google Scholar 

  17. Van den Wijngaart W, Verbrugh H, Theopold HMet al. A non comparative study of Cefprozil at 2 dose levels in the treatment of acute uncomplicated bacterial sinusitis.Clin Ther 1992; 14:306–313.

    Google Scholar 

  18. Simon MW. A prospective randomised study comparing the efficacy of amoxicillin clavulanate, erythromycin sulfisoxazole, cefaclor and Cefprozil in treating acute sinusitis of childhood.AdvTher 1997; 14:64–72.

    CAS  Google Scholar 

  19. McCarty JM, Renteria A. Treatment of pharyngitis and tonsillitis with cefprozil: review of three multicenter trials.Clin Infect Dis 1992:14 (suppl2): S224-S230.

    PubMed  Google Scholar 

  20. Milatovic D, Adam D, Hamilton H, Materman E. Cefprozil vs. Penicillin V in treatment of streptococcal tonsillo-pharyngitis.Antimicrob Agents Chemother 1993; 37:1620–1623.

    PubMed  CAS  Google Scholar 

  21. McCarty JM, Renteria A, Doyle CA, Durham SJ, Hamilton H, Wilber RB. Cefprozil us cefaclor in the treatment of pharyngitis and tonsillitis.Infect Med 1992; 9 (suppl C): 33–43.

    Google Scholar 

  22. Brook I, Aronovitz GH, Pichichero ME. Open-Label, parallel group, multicenter, randomized study of cefprozil versus erythromycin in children with group A streptococcal pharyngitis/tonsillitis.Clin Ther 2001; 23:1889–1900.

    Article  PubMed  CAS  Google Scholar 

  23. Arguedas AG, Zaleska M, Stutman HR, Blumer JL, Hains CS. Comparative trial of Cefprozil Vs. amoxicillin clavulanate potassium in the treatment of children with acute otitis media with effusion.Pediatr Infect Dis J 1991; 10:467–468.

    Article  Google Scholar 

  24. Poole JM, Rosenberg R, Aronovitz GHet al. Cefprozil Vs cefixime and cefaclor in otitis media in children.Infect Med 1992; 9(suppl E): 21–32.

    Google Scholar 

  25. Stutman HR, Arguedas AG. Comparison of cefprozil with other antibiotic regimens in the treatment of children with acute otitis media.Clin Infect Dis 1992:14 (suppl 2): S204-S208.

    PubMed  Google Scholar 

  26. Aronovitz GH, Doyle CA, Durham Sj, Wilber RB, Materman E, Simonson C. Cefprozil vs. Amoxicillin clavulanate in the treat-ment of acute otitis media.Infect Med 1992; 9 (suppl C): 19–32.

    Google Scholar 

  27. Gehanno P, Berche P, Boucot Iet al. Comparative efficacy and safety of cefprozil and amoxycillin clavulanate in the treatment of acute otitis media in children.J Antimicrob Chemother 1994; 33:1209–1218.

    Article  PubMed  CAS  Google Scholar 

  28. Aronovitz G. Treatment of upper and lower respiratory tract infections: clinical trials with cefprozil.Pediatr Infect Dis J 1998; 17(Suppl 8): S83-S88.

    Article  PubMed  CAS  Google Scholar 

  29. Pelletier LL Jr. Review of the experience with cefprozil for the treatment of lower respiratory tract infections.Clin Infect Dis 1992; 14 (Suppl 2): S238-S243.

    PubMed  Google Scholar 

  30. Ball P. Efficacy and safety of cefprozil versus other beta-lactam antibiotics in the treatment of lower respiratory tract infections.Eur J Clin Microbiol Infect Dis 1994; 13:851–856.

    Article  PubMed  CAS  Google Scholar 

  31. Barbarash RA, Solomon E, Thieneman Aet al. Cefprozil vs. amoxicillin clavulanate in mild to moderate lower respiratory tract infections: focus on bronchitis.Infect Med 1992; 9 (suppl E): 4047.

    Google Scholar 

  32. Wilber RB, Hamilton H, Leroy Aet al. Cefprozil vs. cefaclor in the treatment of lower respiratory tract infections: a focus on bronchitis.Infect Med 1992; 9 (suppl E): 33–39.

    Google Scholar 

  33. Bonnet JP, Ginsberg D, Nolen TMet al. Cefprozil vs. Cefuroxime Axetil in mild to moderate lower respiratory tract infections: a focus on bronchitis.Infect Med 1992; 9 (suppl E): 48–56

    Google Scholar 

  34. Solomon E, McCarty JM, Morman MRet al. Comparison of cefprozil and amoxicillin/clavulanate potassium in the treatment of skin and skin structure infections in adults.Adv Ther 1992; 9:156–165.

    Google Scholar 

  35. Parish LC, Doyle CA, Durham SJ, Wilber RB. Cefprozil versus cefaclor in the treatment of mild to moderate skin and skin structure infections.Clin Ther 1992; 14:458–469.

    PubMed  CAS  Google Scholar 

  36. Trujillo M, Ehrett S, Hoyt-Sehnert MJ, Shelton S, McCracken GH Jr. Safety and efficacy of cefprozil as part of a parenteral-oral antibiotic regimen for the treatment of suppurative skeletal infections in children.Clin Infect Dis 1996 Oct; 23(4): 843.

    PubMed  CAS  Google Scholar 

  37. Christenson JC, Gooch WM, Herrod JN, Swenson E. Comparative efficacy and safety of cefprozil and cefaclor in the treatment of acute uncomplicated urinary tract infections.J Antimicrob Chemother 1991; 28:581–586.

    Article  PubMed  CAS  Google Scholar 

  38. Iravani A, Doyle CA, Durham SJ, Wilber RB. Cefprozil versus cefaclor in the treatment of acute and uncomplicated urinary tract infections. Cefprozil Multicenter Study Group.Clin Ther 1992; 14:314–326.

    PubMed  CAS  Google Scholar 

  39. Siberry GK, Iannone R, eds.The Harriet Lane Handbook, The Johns Hopkins Hospital, 15th ed. Philadelphia; Mosby, 2000: pp 662.

    Google Scholar 

  40. Wilber RB, Doyle CA, Durham SJ, Conetta BJ, De Graw SS, Leigh A. Safety profile of cefprozil.Clin Infect Dis 1992; 14: S264-S271.

    PubMed  Google Scholar 

  41. Lower N, Kearns GL, Young RA, Wheeler JG. Serum sickness like reactions associated with cefprozil therapy.J Pediatr 1994; 125:325–328.

    Article  Google Scholar 

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Author notes

  1. S. K. Kabra

    Present address: Department of Paediatrics, All India Insitute of Medical Sciences, Ansari Nagar, 110029, New Delhi

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  1. Department of Paediatrics, All India Insitute of Medical Sciences, Ansari Nagar, 110029, New Delhi

    Sumit Bhargava & Rakesh Lodha

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Bhargava, S., Lodha, R. & Kabra, S.K. Cefprozil : A Review. Indian J Pediatr 70, 395–400 (2003). https://doi.org/10.1007/BF02723613

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