Abstract
Typical megaileum occurred in young male Wistar rats three months after ileum myenteric plexus denervation. An average of 58.4% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in an 8 nm ring-shaped histological sectfrom the midportion of the treated segment. A morphometric study showed that the increased thickness of the megaileum wall was due to muscle hypertrophy and mucosal hyperplasia. The potential usefulness of this model of megaileum is emphasized.
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Garcia, S.B., Pinto, L.Z., Zucoloto, S. et al. Experimental megaileum. Res. Exp. Med. 195, 249–253 (1995). https://doi.org/10.1007/BF02576795
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DOI: https://doi.org/10.1007/BF02576795