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A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment

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Abstract

A competition model describing tumor-normal cell interaction with the added effects of periodically pulsed chemotherapy is discussed. The model describes parameter conditions needed to prevent relapse following attempts to remove the tumor or tumor metastasis. The effects of resistant tumor subpopulations are also investigated and recurrence prevention strategies are explored.

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  1. John Carl Panetta

    Present address: Department of Mathematics, Penn State Erie, The Behrend College, Station Road, 16563-0203, Erie, PA

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  1. Department of Mathematics and Statistics, Old Dominion University, 23529, Norfolk, VA, USA

    John Carl Panetta

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  1. John Carl Panetta
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Panetta, J.C. A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment. Bltn Mathcal Biology 58, 425–447 (1996). https://doi.org/10.1007/BF02460591

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  • DOI: https://doi.org/10.1007/BF02460591

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