Abstract
Urinary excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined in 10 normal subjects on 3 different diets, containing a very low protein, a low protein and a high protein amount. Foodstuffs which could contain histamine were excluded. The mean excretion ofN τ-methylhistamine on the second day of each diet amounted to 0.861 μmol/24 h, 1.051 μmol/24 h and 1.378 μmol/24 h, respectively. The excretions of histamine andN τ-methylimidazoleacetic acid were not affected.
In 6 normal persons on a protein low diet, the excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined for 10 days. On the fifth day, to 3 persons 200 μmol of histamine was given orally, the other 3 persons received a high protein diet. The persons receiving histamine showed a strongly enhanced excretion ofN τ-methylimidazoleacetic acid, corresponding to 36.1% of the administered histamine, whereas the urinary excretions of histamine andN τ-methylhistamine were only slightly elevated. On the high protein diet, only the excretion ofN τ-methylhistamine was slightly elevated.
The urinary excretions of histamine in the female subjects sometimes showed unexpectedly high values. Most probably, this phenomenon is attributable to bacterial histamine production in the urogenital tract.
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Keyzer, J.J., Breukelman, H., Wolthers, B.G. et al. Urinary excretion of histamine and some of its metabolites in man: Influence of the diet. Agents and Actions 15, 189–194 (1984). https://doi.org/10.1007/BF01972348
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DOI: https://doi.org/10.1007/BF01972348