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Toll-Like Receptors (TLRs) and Innate Immunity pp 87–109Cite as

Fungal Recognition by TLR2 and Dectin-1

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 183))

The innate immune system utilizes multiple receptors to recognize fungal pathogens, and the net inflammatory response is controlled by interactions between these receptors. Many fungi are recognized, at least in part, by Toll-like receptor 2 (TLR2) and Dectin-1. Examination of the roles these receptors play together and on their own is a useful model for understanding the interplay between innate immune receptors. This review focuses on the role(s) of TLR2 and Dectin-1 in triggering inflammatory responses, transcription factor activation, phagocytosis, and reactive oxygen production in response to fungi.

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Authors and Affiliations

  1. Immunobiology Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA

    Helen S. Goodridge & David M. Underhill

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  1. Helen S. Goodridge
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  2. David M. Underhill
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Editors and Affiliations

  1. Institut für Immunologie BMFZ, Philipps-Universität Marburg, Hans-Meerwein-Str. 2, D-35043, Marburg, Germany

    Stefan Bauer

  2. Abteilung für Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, D-53105, Bonn, Germany

    Gunther Hartmann

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Goodridge, H.S., Underhill, D.M. (2008). Fungal Recognition by TLR2 and Dectin-1. In: Bauer, S., Hartmann, G. (eds) Toll-Like Receptors (TLRs) and Innate Immunity. Handbook of Experimental Pharmacology, vol 183. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72167-3_5

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