Abstract
To evaluate therapeutic efficacy and to investigate involved molecular mechanisms of cell-based therapy in osteoporosis, the generation of a clinically relevant model is critically important. Herein, we describe detailed methods in generation of an immune-deficient osteoporotic murine model, and application of human umbilical cord blood-derived stem cells to assess their therapeutic efficacy.
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Acknowledgements
This work was supported in part by National Institutes of Health grants, K01 AR054114 (NIAMS), SBIR R44 HL092706-01 (NHLBI), Pelotonia Idea Award (OSUCCC), and The Ohio State University start-up fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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Aggarwal, R., Pompili, V.J., Das, H. (2014). Generation of Osteoporosis in Immune-Compromised Mice for Stem Cell Therapy. In: Christ, B., Oerlecke, J., Stock, P. (eds) Animal Models for Stem Cell Therapy. Methods in Molecular Biology, vol 1213. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1453-1_17
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DOI: https://doi.org/10.1007/978-1-4939-1453-1_17
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Publisher Name: Humana Press, New York, NY
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Online ISBN: 978-1-4939-1453-1
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