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Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures

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Abstract

Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature. In this review, we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities, covering literatures published during 1982–2019.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 41606174; 21877025), the Scientific Research Foundation of Hebei educational committee (No. BJ2020048), the China Postdoctoral Science Foundation (No. 2019M661045), and the Natural Science Interdisciplinary Research Program of Hebei University (No. DXK201913).

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  1. College of Pharmaceutical Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China

    Zhi-Hui Meng, Tian-Tian Sun, Guo-Zheng Zhao, Yu-Fei Yue, Qing-Hua Chang, Hua-Jie Zhu & Fei Cao

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ZHM and TTS wrote the paper. GZZ and YFY collected the data. QHC analyzed the data. FC and HJZ designed, directed and revised the manuscript.

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Meng, ZH., Sun, TT., Zhao, GZ. et al. Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures. Mar Life Sci Technol 3, 44–61 (2021). https://doi.org/10.1007/s42995-020-00072-w

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