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Genetic characterization of Chikungunya virus circulating in individuals from Paraná, Brazil

  • Bacterial, Fungal and Virus Molecular Biology - Short Communication
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Abstract

Phylogenetic analysis carried out in several Brazilian regions shows the circulation of the Asian and East-Central South African (ECSA) Chikungunya virus (CHIKV) genotypes in the country. Until now, there are no genetic studies about CHIKV strains circulating in the South region. In this study, we sequenced 5 new partial sequences of the CHIKV Envelope 1 gene from strains detected in Paraná state during the years 2016–2017. Maximum likelihood and neighbor-joining trees grouped all sequences in Brazilian branches within ECSA genotype and comparative analysis did not show E1-A226V mutation. However, we identified E1-K211T amino acid substitution in a sample demonstrating the dispersion of mutant strains in the country.

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Funding

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) – Finance Code 001. Funding was also provided by Fundação Araucária.

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Authors and Affiliations

  1. Universidade Estadual de Maringá-UEM, Avenida Colombo, Maringá, Paraná, 5790, 87020-900, Brazil

    Deborah de Castro Moreira, Francisco Ferreira Duarte Junior, José Renato Pattaro Júnior, Fernando Américo Jorge, Fabiana dos Santos Rando, Maria Aparecida Fernandez & Dennis Armando Bertolini

  2. Faculdade de Medicina da Universidade de São Paulo – USP, São Paulo, Brazil

    Mateus Vaillant Thomazella

  3. Laboratório Central do Estado do Paraná – LACEN-PR, Curitiba, Paraná, Brasil

    Mayra Marinho Presibella & Irina Nastassja Riediger

Authors
  1. Deborah de Castro Moreira
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  2. Francisco Ferreira Duarte Junior
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  3. José Renato Pattaro Júnior
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  4. Fernando Américo Jorge
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  5. Fabiana dos Santos Rando
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  8. Irina Nastassja Riediger
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  9. Maria Aparecida Fernandez
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  10. Dennis Armando Bertolini
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Contributions

Conceptualization, D.C.M and D.A.B.; methodology, F.F.D.J and J.R.P.J; software, D.C.M and F.S.R.; validation, D.A.B and M.V.T; resources, M.M.P; I.N.R; data curation, M.A.F.; writing—original draft preparation, D.C.M.; writing—review and editing, D.A.B, F.A.J, and M.V.T..; supervision, D.A.B.

Corresponding author

Correspondence to Deborah de Castro Moreira.

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Ethics approval

This study was approved by the Permanent Research Ethics Committee of the State University of Maringá (protocol no. 1.618.106).

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The authors declare no competing interests.

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de Castro Moreira, D., Junior, F.F.D., Júnior, J.R.P. et al. Genetic characterization of Chikungunya virus circulating in individuals from Paraná, Brazil. Braz J Microbiol 53, 641–645 (2022). https://doi.org/10.1007/s42770-022-00680-x

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  • DOI: https://doi.org/10.1007/s42770-022-00680-x

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