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Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis

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Abstract

Introduction

The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored.

Objective

In light of the recent publication of studies on these specific findings, particularly regarding male patients with breast cancer, we performed an updated meta-analysis to investigate a more reliable estimate.

Methods

This meta-analysis included 26 published studies selected in a search of electronic databases up to January 2018, including 118,735 breast cancer cases and 195,807 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between 1100delC and breast cancer.

Results

Meta-analysis results suggested that 1100delC contributed to an increased breast cancer risk in overall populations (OR 2.89; 95% CI 2.63–3.16). Subgroup analysis found ORs of 3.13 (95% CI 1.94–5.07) for male breast cancer, 2.88 (95% CI 2.63–3.16) for female breast cancer, 2.87 (95% CI 1.85–4.47) for early-onset breast cancer, 2.92 (95% CI 2.65–3.22) for invasive breast cancer, and 3.21 (95% CI 2.41–4.29) for familial breast cancer. The sensitivity analysis suggested that results of this meta-analysis were generally robust.

Conclusion

CHEK2*1100delC is associated with an increased risk of both female and male breast cancer.

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Author notes

  1. Mingming Liang and Yun Zhang contributed equally to this work.

Authors and Affiliations

  1. Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China

    Mingming Liang, Yun Zhang, Min Min, Tingting Shi & Yehuan Sun

  2. The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, 230022, China

    Chenyu Sun

  3. Avalon University School of Medicine, Santa Rosaweg 122 - 124, Willemstad, Curaçao

    Feras Kamel Rizeq

  4. Center for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China

    Yehuan Sun

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  1. Mingming Liang
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Correspondence to Yehuan Sun.

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No sources of funding were used to conduct this study or prepare this manuscript.

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ML, YZ, CS, FKR, MM, TS, YS have no conflicts of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Liang, M., Zhang, Y., Sun, C. et al. Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis. Mol Diagn Ther 22, 397–407 (2018). https://doi.org/10.1007/s40291-018-0344-x

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