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Effect of selenium supplementation on glycemic indices: a meta-analysis of randomized controlled trials

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Journal of Diabetes & Metabolic Disorders Aims and scope Submit manuscript

Abstract

Purpose

The association between selenium supplementation and glycemic indices seems to be a controversial issue. This systematic review and meta-analysis was conducted to evaluate the effect of selenium supplementation on glycemic indices.

Methods

We systematically searched PubMed/MEDLINE, ISI/WOS, and Scopus (from their commencements up to Jan 2016) for relevant studies examining the association between intake of selenium and glycemic indices. The data were extracted from relevant qualified studies and estimated using the random-effect or pooled model and standardized mean difference (SMD) with 95% confidence interval (CI).

Results

Twelve articles published between 2004 and 2016 were included. In all the studies, the participants were randomly assigned to an intervention group (n = 757) or a control group(n = 684). All the studies were double blind, placebo controlled trials. Selenium supplementation resulted in a significant decrease in homeostasis model of assessment-estimated β-cell function (HOMA-B) (SMD: -0.63; 95%CI: −0.89 to −0.38) and a significant increase in quantitative insulin sensitivity check index (QUICKI) (SMD: by 0.74; 95%CI: 0.49 to 0.1) as compared with the controls. There were no statistically significant improvements in glycemic indices, such as fasting plasma glucose (FPG), insulin, homeostasis model of assessment-estimated insulin resistance (HOMA-IR), Hemoglobin A1c (HbA1c) and adiponectin.

Conclusion

This meta-analysis indicated that selenium supplementation significantly decreased HOMA-B and increased QUICKI score. There was no statistically significant improvement in FPG, insulin, HOMA-IR, HbA1c and adiponectin indices following selenium supplementation.

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Acknowledgements

This study was funded by Alborz University of Medical Sciences. The authors are thankful of Emam Ali clinical research development unit for their assistance.

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Authors and Affiliations

  1. Department of Basic and Clinical Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

    Armita Mahdavi Gorabi

  2. School of Public Health, Iran University of Medical Sciences, Tehran, Iran

    Motahareh Hasani

  3. Development of Research & Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran

    Shirin Djalalinia

  4. Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Shirin Djalalinia

  5. Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Maryam Zarei

  6. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Hanieh Ejtahed

  7. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

    Mohammad Esmaeili Abdar, Mehdi Azimzadeh & Mostafa Qorbani

  8. Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran

    Hamid Asayesh

  9. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mostafa Qorbani

  10. Social Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Mehdi Noroozi

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  1. Armita Mahdavi Gorabi
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Mostafa Qorbani and Mehdi Noroozi contributed as corresponding authors.

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Mahdavi Gorabi, A., Hasani, M., Djalalinia, S. et al. Effect of selenium supplementation on glycemic indices: a meta-analysis of randomized controlled trials. J Diabetes Metab Disord 18, 349–362 (2019). https://doi.org/10.1007/s40200-019-00419-w

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  • DOI: https://doi.org/10.1007/s40200-019-00419-w

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