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Nano-SiO2: a green, efficient, and reusable heterogeneous catalyst for the synthesis of quinazolinone derivatives

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Abstract

A highly efficient and general method is applied for the multicomponent synthesis of quinazolinone derivatives from cyclocondensation of aromatic aldehydes and dimedone with 2-amino benzimidazole or 3-amino-1,2,4-triazole using nano-SiO2 as a catalyst in acetonitrile at room temperature. In this method, nano-SiO2 was used as a green and reusable catalyst. This synthetic method provides several advantages including excellent yields, short reaction times, simple workup, mild conditions and inexpensiveness, green, and recyclable.

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Acknowledgments

The University of Sistan and Baluchestan is thanked for supporting this work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, PO Box 98135-674, Zahedan, Iran

    Mir Rasul Mousavi & Malek Taher Maghsoodlou

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  1. Mir Rasul Mousavi
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  2. Malek Taher Maghsoodlou
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Correspondence to Malek Taher Maghsoodlou.

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Mousavi, M.R., Maghsoodlou, M.T. Nano-SiO2: a green, efficient, and reusable heterogeneous catalyst for the synthesis of quinazolinone derivatives. J IRAN CHEM SOC 12, 743–749 (2015). https://doi.org/10.1007/s13738-014-0533-4

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  • DOI: https://doi.org/10.1007/s13738-014-0533-4

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