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Synthesis of poly(vinyl alcohol) (PVA) nanofibers incorporating hydroxyapatite nanoparticles as future implant materials

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Abstract

This study examined the mechanical properties of a disc consisting of electrospun poly(vinyl alcohol) (PVA) nanofibers incorporated with high purity hydroxyapatite (HAp) nanoparticles (NPs) for potential hard tissue engineering applications. As HAp NPs are insoluble in a PVA aqueous solution, electrospinning of a colloidal solution was used instead of the conventional process, which is based on completely miscible solutions. The PVA/HAp colloidal solutions were characterized by dynamic light scattering (DLS) and electrophoratic light scattering (ELS), which indicated a unimodal size distribution and negative zeta potential. The physiochemical characterizations confirmed the production of PVA electrospun nanofibers incorporating HAp NPs. To investigate the bioactivity of the produced nanofiber mats, compacted mats with a disc shape were incubated in stimulated body fluid (SBF) at 37 °C for 6 days. SEM indicated that the incorporation of HAp strongly activates the precipitation of the apatite-like materials because the HAp NPs act as seeds that accelerate the crystallization of biological HAp from the utilized SBF.

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Authors and Affiliations

  1. Department of Bionano System Engineering, Chonbuk National University, Jeonju, 561-756, Korea

    Faheem A. Sheikh

  2. Chemical Engineering Department, Faculty of Engineering, El-Minia University, El-Minia, Egypt

    Naseer A. M. Barakat

  3. Department of Polymer Nano Science and Technology, Chonbuk National University, Jeonju, 561-756, Korea

    Muzafar A. Kanjwal

  4. Center for Healthcare Technology Development, Chonbuk National University, Jeonju, 561-756, Korea

    Soo Jin Park

  5. Department of Textile Engineering, Chonbuk National University, Jeonju, 561-756, Korea

    Dae Kwang Park & Hak Yong Kim

Authors
  1. Faheem A. Sheikh
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  2. Naseer A. M. Barakat
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  3. Muzafar A. Kanjwal
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  4. Soo Jin Park
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  5. Dae Kwang Park
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  6. Hak Yong Kim
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Correspondence to Naseer A. M. Barakat or Hak Yong Kim.

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Sheikh, F.A., Barakat, N.A.M., Kanjwal, M.A. et al. Synthesis of poly(vinyl alcohol) (PVA) nanofibers incorporating hydroxyapatite nanoparticles as future implant materials. Macromol. Res. 18, 59–66 (2010). https://doi.org/10.1007/s13233-009-0111-2

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  • DOI: https://doi.org/10.1007/s13233-009-0111-2

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