Abstract
Adenoid cystic carcinoma is very rare, with an incidence of 0.1 to 0.26 per one lakh people. It is the second most common primary malignancy of the trachea. The etiology, clinical manifestation and prognosis of ACC trachea in Indian scenario has not been discussed so far. We evaluated the clinical presentation, treatment and follow up details of six patients with ACC of trachea, who were treated in our Institute from January, 2006 to October,2014. Cough with expectoration, exertional dyspnoea and haemoptysis were the most frequent presentations. Proximal trachea was involved in five patients with lesion extending to subglottis in two patients. The male: female ratio was equal and most patients presented in the 4th decade of their life. Two patients were treated with total laryngectomy with proximal tracheal resection, two with tracheal resection and anastomosis and one with window resection. Four patients who were treated surgically received post operative radiation. One patient with inoperable disease was treated with radical radiotherapy. All the patients are doing well with a median follow up period of 42.8 months.
Similar content being viewed by others
References
Macchiarini P (2006) Primary tracheal tumours. Lancet Oncol 7:83–91
Bhattacharyya N (2004) Contemporary staging and prognosis for primary tracheal malignancies: a population-based analysis. Otolaryngol Head Neck Surg 131:639–42
Grillo HC. Surgery of the Trachea and Bronchi (2004) Pmph USA Ltd., Hamilton, Ontario
Shadmehr MB, Farzanegan R, Graili P, Javaherzadeh M, Arab M, Pejhan S et al (2011) Primary major airway tumors; management and results. Eur J Cardiothorac Surg 39:749–54
Price JC, Percarpio B, Murphy PW, Henderson RL (1979) Recurrent adenoid cystic carcinoma of the trachea: intraluminal radiotherapy. Otolaryngol Head Neck Surg 87:614–623
Calzada AP, Miller M, Lai CK, Elashoff DA, Abemayor E, St John MA (2012) Adenoid cystic carcinoma of the airway: a 30-year review at one institution. Am J Otolaryngol 33:226–31
Desai DP, Holinger LD, Gonzales-Crussi F (1998) Tracheal neoplasm in children. Ann Otol Rhinol Laryngol 107:790–96
Kim D, Hwang Y, Choi S, Park C, Lee N, Kim EA (2013) A case of tracheal adenoid cystic carcinoma in a worker exposed to rubber fumes. Ann Occup Environm Med 25:22
Mancuso TF, Brennan MJ (1970) Epidemiological considerations of cancer of the gallbladder, bile ducts and salivary glands in the rubber industry. J Occup Med 12(9):333–341
Vermeulen R, Bos RP, de Hartog J, van Drooge H, Kromhout H (2000) Mutagenic profile of rubber dust and fume exposure in two rubber tire companies. Mutat Res 468(2):165–171
Ahn Y, Chang H, Lim YS, Hah JH, Kwon TK, Sung MW et al (2009) Primary tracheal tumors: review of 37 cases. J Thorac Oncol 4:635–8
Haresh KP, Prabhakar R, Rath GK, Sharma DN, Julka PK, Subramani V (2008) Adenoid cystic carcinoma of the trachea treated with PET-CT based intensity modulated radiotherapy. J Thorac Oncol 3:793–5
Grillo HC, Mathisen DJ (1990) Primary tracheal tumors: treatment and results. Ann Thorac Surg 49:69–77
Moran CA (1995) Primary salivary gland type tumours of lung. Semin Diag Pathol 12:106–22
Hollingsworth HM (1987) Wheezing and stridor. Clin Chest Med 8:231–40
Geffin B, Grillo HC, Cooper JD, Pontoppidan H (1971) Stenosis following tracheostomy for respiratory care. JAMA 216:1984–88
Hajdu SI, Huvos AG, Goodner JT, Foote FW Jr, Beattie EJ Jr (1970) Carcinoma of the trachea. Clinicopathologic study of 41 cases. Cancer 25:1448–1456
Morrison MD, Salkeld U (1982) Prognostic factors in primary tracheal malignancy. J Otolaryngol 11:204–208
(2004) Cystic carcinoma of the airways: helical CT and histopathologic correlation. AJR Am J Roentgenol 183:277–81
Compeau CG, Keshavjee S (1996) Management of tracheal neoplasms. Oncologist 1:347–53
Azar T, Abdulkarim FW, Tucker HM (1998) Adenoid cystic carcinoma of trachea. Laryngoscope 108:1297–1300
Grillo HC (1981) Tumors of the cervical trachea. In: Suen JY, Myers EN (eds) Cancer of the Head and Neck. Churchill Livingstone, New York, pp 500–522
Parrish CM, Jones RE (1960) Primary tracheal tumors. Am Surg 26:95–98
Muller A, Stockamp B, Schnabel T (2000) Successful primary radiation therapy of adenoid cystic carcinoma of lung. Oncology 58:15–17
Haddad RI, Posner MR, Busse PM, et al (2006) Chemoradiotherapy for adenoid cystic carcinoma: preliminary results of an organ sparing approach. Am J Clin Oncol 153–157
Regnard JF, Fourquier P, Levasseur P (1996) Results and prognostic factors in resections of primary tracheal tumors: a multicenter retrospective study. The French society of cardiovascular surgery. J Thorac Cardiovasc Surg 111:808–13
Gaissert HA, Grillo HC, Shadmehr MB, et al (2004) Long-term survival after resection of primary adenoid cystic and squamous cell carcinoma of the trachea and carina. Ann ThoracSurg 1896–1897
Maziak DE, Todd TR, Keshavjee SH, Winton TL, Van Nostrand P, Pearson FG (1996) Adenoid cystic carcinoma of the airway:thirty-two-year experience. J Thorac Cardiovasc Surg 112:1522–31
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kumar N, S., Iype, E.M., Thomas, S. et al. Adenoid Cystic Carcinoma of the Trachea. Indian J Surg Oncol 7, 62–66 (2016). https://doi.org/10.1007/s13193-015-0453-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13193-015-0453-5