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Effect of APOE Gene Polymorphism on Early Cerebral Perfusion After Aneurysmal Subarachnoid Hemorrhage

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Abstract

High mortality following aneurysmal subarachnoid hemorrhage (aSAH) occurs in the early phase, but the underlying mechanism of early brain injury (EBI) in aSAH was less elucidated. In this study, we aimed to investigate the association of apolipoprotein E (APOE) genotypes and early cerebral perfusion after aSAH. We collected venous blood of aSAH patients on admission for APOE genotype identification, applying computed tomography perfusion (CTP) scanning within 24 h after onset. The CTP parameters between patients with different APOE genotypes were compared. Then, a positive item was chosen for separate uni- and multivariate logistic regression analyses to seek its risk factors. Our results showed mean transit time (MTT) rather than other parameters was significantly longer in patients with the APOEε4 allele, compared to those without APOEε4 (6.45 ± 1.17 versus 5.83 ± 0.84 s, P = 0.019). APOEε4 acted as an independent risk factor for MTT prolongation (>5.9 s) in uni- (P = 0.031, OR = 3.960, 95 % CI = 1.131–13.863) and multivariate (P = 0.019, OR = 9.822, 95 % CI = 1.458–66.193) logistic regression analyses, respectively. APOEε4 may induce cerebral perfusion impairment in the early phase, contributing to EBI following aSAH, and assessment of APOE genotypes could serve as a useful tool in the prognostic evaluation and therapeutic management of aSAH.

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Funding

This study was funded by a grant from the Guizhou Science and Technology Department (2013, 2332).

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Authors and Affiliations

  1. Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

    Chongjie Cheng, Li Jiang, Zhijian Huang & Xiaochuan Sun

  2. School of Public Health and Health Management, Chongqing Medical University, Chongqing, China

    Yanhong Yang

  3. Department of Neurosurgery, The Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China

    Haitao Wu

Authors
  1. Chongjie Cheng
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  2. Li Jiang
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  3. Yanhong Yang
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  4. Haitao Wu
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  5. Zhijian Huang
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  6. Xiaochuan Sun
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Corresponding author

Correspondence to Xiaochuan Sun.

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Ethical Approval

The study was approved by the ethics committee of the coordinating institution and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All the patients gave their informed consent prior to their inclusion in the study.

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The authors declare that they have no competing interests.

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Cheng, C., Jiang, L., Yang, Y. et al. Effect of APOE Gene Polymorphism on Early Cerebral Perfusion After Aneurysmal Subarachnoid Hemorrhage. Transl. Stroke Res. 6, 446–450 (2015). https://doi.org/10.1007/s12975-015-0426-6

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  • DOI: https://doi.org/10.1007/s12975-015-0426-6

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